Premium Myricetin Powder | CAS 529-44-2 | ≥ 98% HPLC
Botanical Source: Ampelopsis grossedentata (Vine Tea)
CAS Number: 529-44-2
Content Specification: ≥ 98.0% (HPLC)
Molecular Formula: C₁₅H₁₀O₈
Molecular Weight: 318.24 g/mol
Appearance Profile: Yellowish-green powder
Shelf Life: 24 Months
Premium Myricetin Powder (≥ 98.0% HPLC)
Manufactured by Xi'an Tihealth Biotechnology Co., Ltd.
Xi'an Tihealth Biotechnology Co., Ltd. is a globally recognized, cGMP-aligned B2B manufacturer of high-purity Myricetin. As a prominent flavonol aglycone, Myricetin serves as the structural foundation for numerous bioactive glycosides, yet it possesses uniquely potent pharmacological properties in its isolated form. While many suppliers struggle with extracting this compound efficiently without thermal degradation, Tihealth masters the isolation process by sourcing exclusively from the flavonoid-rich leaves of *Ampelopsis grossedentata* (Vine Tea), achieving an exceptional purity threshold of ≥ 98.0% via HPLC.
Characterized by its distinctive yellowish-green micro-crystalline profile, our Myricetin operates as a formidable biological agent. It aggressively eliminates intracellular free radicals to delay cellular senescence, actively down-regulates pro-inflammatory cytokines, and provides critical hepatoprotective (liver-defending) support. Furthermore, its natural antimicrobial properties make it a premier stabilizer for the dermal matrix. Rigorously audited to ensure trace-level heavy metals and absolute microbial safety, Tihealth's Myricetin is the definitive active ingredient for longevity supplements, liver-health nutraceuticals, and advanced cosmeceutical formulations.
Technical Data Sheet (TDS) & Quality Specifications
| Analysis Parameter | Target Specification Limit | Batch Output Profile | Analytical Methodology |
|---|---|---|---|
| Biological Origin | Leaves of *Ampelopsis grossedentata* | Conforms | Microscopic / DNA Tracking |
| Myricetin Purity Assay | ≥ 98.0% (Dry Basis) | 98.6% | HPLC-UV Calibration |
| CAS Registry Number | 529-44-2 | Confirmed | Molecular Identification |
| Molecular Profile | C15H10O8 / 318.24 g/mol | Matches Theoretical | Mass Spectrometry |
| Appearance Parameter | Yellowish-green fine powder | Yellowish-green Powder | Visual Inspection |
| Loss on Drying | ≤ 5.0% | 1.8% | Gravimetric (USP <731>) |
| Heavy Metals (Total) | ≤ 10.0 ppm | < 5.0 ppm | ICP-MS Spectrometry |
| Arsenic (As) / Lead (Pb) | ≤ 1.0 ppm / ≤ 2.0 ppm | < 0.5 ppm / < 0.2 ppm | ICP-MS Spectrometry |
| Total Aerobic Count | ≤ 1000 CFU/g | < 50 CFU/g | USP <61> Microbial Limit |
Advanced Processing & Quality Engineering
Aglycone Fractional Precipitation
Isolating the pure aglycone (Myricetin) from its naturally occurring glycosides requires extreme precision. Tihealth executes a controlled fractional precipitation process within a specialized solvent matrix. By manipulating the pH and thermal kinetics, we selectively crystalize the Myricetin molecule while stripping away inactive sugars and dense tannins inherent in Vine Tea.
Vacuum Low-Thermal Desolvation
Myricetin features multiple hydroxyl groups that are highly prone to oxidative degradation when exposed to high heat and atmospheric oxygen. Our processing line utilizes an optimized low-temperature vacuum drying loop. This eliminates moisture and completely controls residual solvents safely below pharmacopoeia limits, preserving the compound's potent bioactivity.
Chromatographic Purification
To achieve the stringent ≥ 98.0% HPLC purity threshold, every batch undergoes advanced column chromatography. This essential step meticulously separates Myricetin from structurally similar flavonols (like dihydromyricetin or quercetin), yielding an ultra-pure, uniform yellowish-green powder free from grittiness and commercial fillers.
Evidence-Based Mechanisms of Cellular Efficacy
Profound Intracellular ROS Scavenging (Anti-Aging)
Myricetin demonstrates magnificent radical scavenging dynamics within cellular matrices. Its specific hexahydroxyflavone structure actively donates hydrogen atoms to neutralize highly reactive superoxide anions and hydroxyl radicals. This aggressively down-regulates intracellular lipid peroxidation, mitigating accumulated body damage and delaying cellular senescence.
Hepatoprotective (Liver-Protecting) Pathways
Clinically recognized for its liver-defending properties, Myricetin helps protect hepatic tissues from oxidative stress and chemical-induced toxicity. It stabilizes hepatocyte membranes and modulates hepatic enzyme leakage, offering robust physiological support for liver detoxification and overall metabolic health.
Down-Regulation of Pro-Inflammatory Cascades
Operating at the transcriptional level, it systematically limits the overactivation of inflammatory signaling pathways. By reducing the transcription of downstream pro-inflammatory cytokines, it effectively eases physiological redness, heat discomfort, and localized cellular inflammation.
Dermal Matrix Stabilization & Antimicrobial Action
In dermatological applications, Myricetin inhibits the enzymatic breakdown of collagen and elastin while exhibiting innate antibacterial properties. This dual-action stabilizes the dermal matrix, purifies the skin flora, and establishes it as a highly functional active in premium cosmeceutical formulations.
Targeted Industrial Applications
Hepatic & Liver Support Nutraceuticals
The foundational API for premium dietary capsules and functional regimens targeted at managing liver detoxification, reducing hepatic oxidative stress, and supporting overall organ health.
Cellular Longevity Supplements
A premier botanical active ingredient for engineering antioxidant capsules and daily cellular protection tablets aimed at mitigating systemic aging and physiological decline.
Advanced Cosmeceutical Skincare
Integrated into high-end serums and daily recovery crèmes. It acts as a powerful anti-collagenase agent and natural antimicrobial stabilizer to soothe skin redness and heat discomfort.
Anti-Inflammatory Functional Foods
Employed as a functional raw additive in health-oriented wellness products designed to regulate internal inflammatory responses and provide sustained cellular defense.
Contract Manufacturing & Global Supply Chain Assurance
♦ Rigorous Botanical Authentication
Protect your final products from audit failures. We explicitly verify our plant origin, guaranteeing 100% authentic *Ampelopsis grossedentata* raw materials, completely free from synthetic chemical adulterants or undeclared multi-species bioproduct fillers.
♦ Trace Analytical Verification
Quality is documented with mathematical certainty. Every shipment comes with a comprehensive Certificate of Analysis (COA) detailing precise HPLC quantification, ensuring our ≥ 98.0% purity threshold clears any stringent third-party quality control audit.
♦ Secure Commercial Fulfillment
We protect your intellectual proprietary secrets with absolute security. We support advanced contract manufacturing and issue full cGMP-compliant technical documentation packages to guarantee immediate custom clearance globally.
Packaging, Logistics & Secure Payment
Reliable B2B Supply Chain Solutions
We provide pharmaceutical-grade aseptic packaging, efficient global logistics (Air/Sea freight with dual customs clearance), and secure multi-currency payment methods to ensure seamless, oxidation-free cross-border transit for our B2B procurement partners.
Procurement & Formulation FAQ
01. What is the fundamental difference between Myricetin and its glycoside derivatives (like Myricitrin)?
Myricetin is the isolated aglycone molecule, meaning it is free from any attached sugar chains. This structural purity grants it a vastly higher concentrated antioxidant capacity per milligram compared to its glycoside variants. Formulators utilize Myricetin when maximum biological potency and lipophilic membrane penetration are required, specifically in high-end encapsulation.
02. Why do you use *Ampelopsis grossedentata* (Vine Tea) rather than Bayberry as the extraction source?
*Ampelopsis grossedentata* contains an exceptionally dense, natural concentration of related flavonoids (specifically Dihydromyricetin), which serves as an ideal precursor biomass for yielding ultra-high purity Myricetin aglycone. This specific sourcing ensures maximum commercial scalability, absolute botanical sustainability, and superior cost-effectiveness for bulk B2B manufacturing.
03. Why does high-purity ≥ 98% Myricetin appear yellowish-green?
The distinctive yellowish-green hue is a vital indicator of genuine, unadulterated flavonol chemistry. The native conjugated double bonds within the molecule naturally reflect this spectrum. Powders that appear completely stark white often signal severe industrial chemical bleaching, which damages the active chromophore and severely diminishes antioxidant efficacy.
04. What are the best formulation strategies considering its lipophilic nature?
Because pure Myricetin aglycone is naturally lipophilic (fat-soluble), it has limited solubility in plain water. To maximize bioavailability in digestive tracts or cosmetic serums, we recommend formulating it alongside lipid-based carriers, integrating it into liposomal matrices, or utilizing gentle emulsification techniques during the compounding phase.
05. What are your commercial minimum parameters and shipping workflows?
Our standard B2B commercial production MOQ is 25kg, packed securely in industrial fiber drums with protective double inner bags. For laboratory testing, validation trials, and formulation pilots, we easily accommodate specialized micro-lots starting at 1kg in sealed aluminum foil bags. Dispatch takes 3-5 working days for standard stock volumes.
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