Grey Tree Flower Polysaccharide
English name: Maitake Mushroom Extract
Latin name: Grifola frundosa
Product specifications: 30% -95%
Appearance: Brown powder
Active ingredients: Grey tree flower polysaccharide, a heteropolysaccharide complex composed of polysaccharide, glucose, xylose, fucose, xylose, mannose, lactulose, and a small amount of protein
Plant source: The fruiting body of the gray tree flower in the family Polyporus
Product packaging: 1kg/aluminum foil bag; 5kg/cardboard box;
25kg/cardboard drum (or packaged according to customer requirements)
Storage conditions: This product should be sealed and shaded, and stored in a dry, cool, and well ventilated place
Validity period: 24 months
Clinical-Grade Grifola Frondosa Polysaccharide (Maitake Extract)
Manufactured by Xi'an Tihealth Biotechnology Co., Ltd.
Xi'an Tihealth is a premier global B2B supplier of highly purified Grifola frondosa Extract, internationally celebrated as Maitake mushroom. To ensure absolute consistency and clinical predictability, we bypass unpredictable wild-sourcing, opting exclusively for optimized, high-activity strains cultivated in strict, ecologically controlled indoor environments.
Utilizing advanced three-stage molecular sieving and specialized protein-polysaccharide separation protocols, we successfully isolate the mushroom's most potent therapeutic matrix: The Maitake D-Fraction (specifically the β-(1→3) and β-(1→6) branching glucans). Standardized to a rigorous purity profile of ≥35% total polysaccharides, our fine, highly dispersible extract exhibits exceptional bioavailability. Extensively documented for its profound immunomodulatory effects and ability to mitigate the severe side effects of clinical radiotherapy/chemotherapy, it serves as a foundational Active Pharmaceutical Ingredient (API) for premium oncology-support nutraceuticals and targeted immune-defense formulations.
Technical Data Sheet (TDS) & Analytical Control
| Analysis Item | Target Specification | Result (Typical Batch) | Methodology |
|---|---|---|---|
| Botanical Source | Fruiting Body of Grifola frondosa | Verified | Macroscopic ID |
| Total Polysaccharides | ≥ 35.0% | 38.6% | Phenol-Sulfuric Acid |
| β-Glucan Fraction | ≥ 60% of total polysaccharides | 68.1% | Enzymatic / Colorimetry |
| Average Molecular Wt. | ~ 1,000 kDa | 980 kDa | GPC |
| Appearance | Brown fine powder | Complies | Visual Assessment |
| Loss on Drying | ≤ 8.0% | 5.4% | Karl Fischer / USP |
| Heavy Metals (Pb, As) | ≤ 2.0 ppm / ≤ 1.0 ppm | 0.1 ppm / 0.2 ppm | ICP-MS |
| Microbiology (Total Plate) | ≤ 1000 CFU/g | 125 CFU/g | ISO 4833-1 |
Manufacturing & Processing Excellence
D-Fraction Targeted Isolation
Generic Maitake powders contain high levels of non-active starches. Tihealth utilizes advanced 3-stage molecular sieving and precise ethanol-precipitation protocols. This specifically isolates the clinically validated "D-Fraction"-a complex of β-(1→6) branched β-(1→3)-glucans-ensuring over 60% higher immunological potency than standard crude extracts.
Liposomal Microencapsulation (Optional)
High-molecular-weight fungal polysaccharides often struggle with poor gastrointestinal absorption (≤50%). To counteract this, we offer an advanced liposomal microencapsulation process. This shields the active β-glucans from stomach acid, boosting intestinal absorption rates to over 70% in in vitro models.
Zero Toxic Solvent Residues
Clinical oncology formulations demand absolute purity. We strictly abandon harsh industrial solvents, utilizing only a food-grade aqueous and ethanol extraction system. Rigorous vacuum evaporation ensures that residual ethanol remains completely undetectable, guaranteeing safety for compromised patients.
Evidence-Based Pharmacological Mechanisms
Oncology Adjuvant Support (Chemo-protection)
Maitake D-Fraction is extensively utilized globally as a clinical adjunct to traditional radiotherapy and chemotherapy. It actively assists in mitigating severe side effects-such as nausea, hair loss, and extreme fatigue-while acting to stabilize systemic white blood cell counts, thereby preventing critical immunosuppression.
Profound Macrophage & NK Cell Activation
The specific β-(1→3) and β-(1→6) branching structures function as highly potent biological response modifiers. They actively bind to TLR4 receptors, significantly stimulating the phagocytic activity of macrophages and accelerating the proliferation of Natural Killer (NK) cells and cytotoxic T-cells.
Metabolic Regulation (Glucose & Lipids)
Exhibits significant potential in managing metabolic syndrome parameters. The bioactive matrix assists in improving cellular insulin sensitivity, thereby helping to regulate fasting blood glucose, while simultaneously acting to lower elevated serum cholesterol and triglyceride levels.
Systemic Antioxidant & Hepatoprotection
Functions as an aggressive free-radical scavenger (demonstrating an IC50 ≤2.0 mg/mL in DPPH assays). This mitigates oxidative stress on cellular DNA, protects hepatic (liver) tissue from chemically induced damage, and supports overall gastrointestinal microbiome health.
Industrial Formulation Applications
Clinical Oncology Nutraceuticals
The core Active Pharmaceutical Ingredient (API) for formulating advanced immune-recovery capsules and specialized medical foods for post-operative patients.
Daily Immune-Support Supplements
Extensively utilized in preventive health formulas, geriatric vitality chewable tablets, and targeted viral-defense dietary complexes.
Metabolic Health Formulas
Increasingly formulated alongside ingredients like Berberine to create advanced metabolic modulators targeting blood sugar stabilization and cardiovascular health.
Functional RTD Beverages
Through our advanced nanofiltration processing, it integrates seamlessly into Ready-To-Drink botanical elixirs and probiotic functional shots without sedimentation.
Contract Manufacturing & Global Supply Chain
♦ Precise Active Customization
We strictly tailor the concentration of Total Polysaccharides (from 35% up to highly concentrated custom fractions) and adjust powder fineness to perfectly match your specific formulation requirements.
♦ Traceable Quality Control
Quality is mathematically verifiable. Every batch undergoes strict cGMP-certified analysis via Enzymatic HPLC. We provide full COAs, ensuring heavy metals, pathogens, and pesticide residues strictly comply with global pharmacopeial standards.
♦ Strict Brand Confidentiality
Secure IP protection via NDAs. We offer blind shipping, private label bulk packaging (from 1kg foil bags to 25kg sterile drums), and full FDA/EU regulatory documentation support for global customs clearance.
Packaging, Logistics & Secure Payment
Reliable B2B Supply Chain Solutions
We provide pharmaceutical-grade aseptic packaging, efficient global logistics (Air/Sea freight with dual customs clearance), and secure multi-currency payment methods to ensure seamless, oxidation-free cross-border transit for our B2B procurement partners.
Formulator & Procurement FAQ
01. Do you test specifically for the D-Fraction (β-Glucans)?
Yes. Generic "polysaccharide" testing via UV can detect inactive starches (alpha-glucans). We utilize specialized enzymatic HPLC assays to ensure that the core bioactive D-Fraction-the immuno-stimulating β-(1→6) branched β-(1→3)-glucans-are strictly preserved and quantified on our COA.
02. Is the extract completely water-soluble for beverage applications?
Absolutely. Through advanced nanofiltration and high-speed centrifugation, we completely remove heavy insoluble fungal chitins. The resulting micro-powder disperses rapidly and clearly in warm water, making it perfect for functional RTD drinks without causing sedimentation.
03. How does Maitake (Grifola frondosa) differ from Shiitake (Lentinula) extracts?
While both are excellent immune modulators, Maitake's specific D-Fraction structure is far more heavily cited in clinical literature specifically for its potent synergistic efficacy in oncology adjuvant protocols (chemotherapy support) compared to standard Shiitake extracts.
04. Can you guarantee the product is free from heavy metals?
Yes. Fungi act as bio-accumulators. We proactively mitigate this risk by sourcing exclusively from unpolluted ecological indoor cultivation bases, completely bypassing wild-harvesting. Every batch is verified via ICP-MS to ensure Lead (Pb) remains ≤ 0.5 ppm.
05. What is the Minimum Order Quantity (MOQ) and packaging standard?
Our standard MOQ for mass production is 25kg, packed in heavy-duty cardboard drums lined with double sterile, nitrogen-flushed bags to prevent oxidation and moisture ingress. We also supply 1kg foil bags for pilot manufacturing and R&D trials.
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