Myricitrin Powder | CAS 17912-87-37 | ≥ 95% HPLC | Myrica rubra Extract
Botanical Source: Myrica rubra (Bark / Leaves)
CAS Number: 17912-87-7
Content Specification: ≥ 95.0% (HPLC, Dry Basis)
Molecular Formula: C₂₁H₂₀O₁₁
Molecular Weight: 464.38 g/mol
Appearance Profile: Light yellow to yellow fine crystalline powder
Shelf Life: 24 Months (Stored in sealed, cool, dry & dark conditions)
Premium Myricitrin Powder (≥ 95.0% HPLC)
Manufactured by Xi'an Tihealth Biotechnology Co., Ltd.
Xi'an Tihealth Biotechnology Co., Ltd. is a premier, cGMP-aligned B2B manufacturer and bulk exporter of high-purity Myricitrin. In the global botanical supply chain, formulators frequently confuse Myricitrin with its aglycone counterpart, Myricetin. While molecularly related, standard Myricetin exhibits extreme hydrophobicity and poor thermodynamic stability in watery matrices, rendering it highly ineffective in standard liquid formulation lines. Tihealth addresses this formulation crisis by providing pure, micro-crystalline Myricitrin (Flavonol rhamnoside) extracted exclusively from the sustainable bark and leaves of authentic *Myrica rubra* (Chinese Bayberry).
The attachment of the rhamnose sugar moiety fundamentally alters the molecule's spatial geometry, yielding vastly superior aqueous dispersibility and advanced intestinal membrane permeability. Standardized to an uncompromising ≥ 95.0% Assay via HPLC on a dry basis, our light yellow micro-powder functions as a powerful biological agonist against cellular oxidative breakdown and pro-inflammatory cascades. Operating under stringent ISO9001:2015 frameworks with rigorous trace impurity sifting, Tihealth's Myricitrin represents the pinnacle active intermediate for modern anti-inflammatory therapeutics, brain-health nootropic complexes, and elite dermaceutical lines globally.
Technical Data Sheet (TDS) & Quality Specifications
| Analysis Parameter | Target Specification Limit | Batch Output Profile | Analytical Methodology |
|---|---|---|---|
| Biological Origin | Bark and leaves of *Myrica rubra* | Conforms | Microscopic / TLC Tracking |
| Myricitrin Purity Assay | ≥ 95.0% (Dry Basis) | 95.8% | HPLC-UV Calibration |
| CAS Registry Number | 17912-87-7 | Confirmed | Molecular Identification |
| Molecular Profile | C21H20O11 / 464.38 g/mol | Matches Theoretical | Mass Spectrometry Confirmation |
| Appearance Parameter | Light yellow to yellow fine powder | Light Yellow Fine Powder | Visual Inspection |
| Loss on Drying | ≤ 5.0% | 3.2% | Gravimetric (USP <731>) |
| Heavy Metals (Total) | ≤ 10.0 ppm | < 5.0 ppm | ICP-MS Spectrometry |
| Arsenic (As) / Lead (Pb) | ≤ 2.0 ppm / ≤ 2.0 ppm | < 0.5 ppm / < 0.2 ppm | ICP-MS Spectrometry |
| Total Aerobic Count | ≤ 1000 CFU/g | < 50 CFU/g | USP <61> Microbial Limit |
Advanced Processing & Quality Engineering
Targeted Polarity Crystallization
Crude extraction methods often leave high-density tannins and relative amorphous multi-flavonoids bound to the target molecule. Tihealth uses a multi-tier solvent gradient fractional crystallization process. By locking the exact temperature dynamics and pH balance, we selectively isolate pure, native micro-crystalline Myricitrin particles while avoiding molecular ring deformation.
Vacuum Low-Thermal Desolvation
Flavonol rhamnosides are highly prone to thermal hydrolysis, which splits the vital rhamnose sugar chain and reverts the batch into unusable hydrophobic myricetin. Our processing line utilizes an optimized low-temperature vacuum drying loop. This eliminates moisture and controls structural remnants safely below rigorous pharmacopoeia limits without causing dark discoloration.
Phytochemical Stabilization Audit
To ensure consistent workflow integration in complex downstream functional supplements and clean cosmetic serum lines, every single batch passes intensive counter-current chromatography sorting. This ensures uniform particle size distributions, superb color-fast stability, and prevents the gritty sedimentation typical of under-refined powders.
Evidence-Based Mechanisms of Cellular Efficacy
Intracellular Reactive Oxygen Species (ROS) Scavenging
Myricitrin demonstrates magnificent radical scavenging dynamics within cellular matrices. Its multi-hydroxyl configuration actively donates hydrogen atoms to neutralize highly reactive superoxide anions and hydroxyl radicals. This down-regulates intracellular lipid peroxidation, providing strong biological cytoprotection against environmental oxidative tissue damage.
Down-Regulation of Pro-Inflammatory Cascades
Operating at the transcriptional level, Myricitrin systematically limits the overactivation of the NF-κB signaling pathway. By blocking this cellular master switch, it directly reduces the transcription of downstream pro-inflammatory cytokines (such as TNF-α, IL-6, and IL-1β), serving as an effective botanical active for managing chronic micro-inflammation.
Neural Microglial Modulation & Neuroprotection
Scientific validation indicates that Myricitrin effortlessly crosses into delicate neurological structures where it dampens lipopolysaccharide (LPS)-induced microglial cell over-excitation. By preventing the neuro-inflammatory cascades that cause neuronal apoptosis, it presents profound potential for formulations targeting cognitive protection and memory support complexes.
Broad-Spectrum Microbial Growth Inhibition
The molecular structure of this flavonol glycoside disrupts the cell membrane integrity of hostile pathogens, altering membrane potentials and leaking essential intracellular minerals. This innate antimicrobial property establishes it as a functional preservative agent and supportive physiological stabilizer in health-centric lines.
Targeted Industrial Applications
Functional Health Supplements
A premier botanical active ingredient for engineering antioxidant capsules, daily cellular protection tablets, and complex immune support regimens for aging demographics.
Nootropic & Cognitive Blends
Formulated into premium brain-boosting complexes alongside brain-specific lipids, explicitly leveraging its microglial modulation pathway to support executive function.
Advanced Cosmeceutical Skincare
Utilized as a non-irritating botanical active conditioner in daily recovery crèmes and specialized facial creams to protect baseline cells from UV photo-aging and skin redness.
Clean-Label Natural Preservation
Employed as a multi-functional raw additive in health-oriented wellness products, providing secondary shelf stabilization through its strong built-in antimicrobial activity.
Contract Manufacturing & Global Supply Chain Assurance
♦ Rigorous Botanical Authentication
Protect your final products from audit failures. We explicitly verify our plant origin using thin-layer chromatography and macroscopic validation, guaranteeing 100% authentic *Myrica rubra* raw materials with absolute transparency.
♦ Trace Analytical Verification
Quality is documented with mathematical certainty. Every shipment comes with a comprehensive Certificate of Analysis (COA) detailing precise HPLC quantification, ash indices, and total freedom from multi-species unlisted fillers.
♦ Secure Commercial Fulfillment
We protect your intellectual proprietary secrets with absolute security. We support advanced contract manufacturing and issue full cGMP-compliant technical documentation packages to guarantee immediate custom clearance globally.
Packaging, Logistics & Secure Payment
Reliable B2B Supply Chain Solutions
We provide pharmaceutical-grade aseptic packaging, efficient global logistics (Air/Sea freight with dual customs clearance), and secure multi-currency payment methods to ensure seamless, oxidation-free cross-border transit for our B2B procurement partners.
Procurement & Formulation FAQ
01. What is the fundamental operational difference between Myricitrin and Myricetin?
The core difference lies in the formulation chemistry and solubility profile. Myricetin is the aglycone molecule, which exhibits extreme hydrophobicity (it will not dissolve in water), making it highly problematic for liquid formulation lines or cosmetics. Myricitrin features a bound rhamnose sugar moiety that drastically alters its molecular polarity. This yields superior aqueous dispersibility and much better intestinal absorption rates, making it highly preferred for functional manufacturing.
02. Why does high-purity Myricitrin appear light yellow rather than white?
This is a critical hallmark of authentic flavonol chemical architecture. Molecules within this class possess extensive conjugated double-bond structures (chromophores) that natively absorb specific ultraviolet wavelengths, reflecting a distinct pale yellow or yellow shade. Beware of suppliers claiming "95% Myricitrin" that presents as a perfectly pure white powder, as it often indicates heavy chemical bleaching or intense active dilution.
03. Why is *Myrica rubra* preferred over *Myrica cerifera* for global B2B procurement?
While both botanical species synthesize the target molecule, *Myrica rubra* (Chinese Bayberry) provides a significantly more robust, sustainable, and concentrated biomass source natively grown in Asia. Sourcing from *Myrica rubra* ensures industrial volume scale and absolute price consistency, bypassing the extreme supply constraints associated with wild-harvested *Myrica cerifera* bark.
04. Does the powder maintain thermal stability during functional product manufacturing?
Yes, provided you respect its molecular thresholds. Myricitrin is highly stable at ambient processing temperatures. However, it is an organic glycoside, so exposure to prolonged cooking temperatures above 80°C in strongly acidic environments can cause partial thermal cleavage. We recommend introducing the active micro-powder during the secondary cool-down phases of your manufacturing workflow.
05. What are your commercial minimum parameters and shipping workflows?
Our standard B2B commercial production MOQ is 25kg, packed securely in industrial fiber drums with protective double inner bags. For laboratory testing, validation trials, and formulation pilots, we easily accommodate specialized micro-lots starting at 1kg in sealed aluminum foil bags. Dispatch takes 3-5 working days for stock volumes.
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