Polygonum Cuspidatum Extract

Xi'an Tihealth is a premier global B2B manufacturer of highly purified Polygonum Cuspidatum Extract (Giant Knotweed Root). We rigorously source our raw materials from traceable, high-altitude cultivation bases, ensuring an exceptionally pristine biomass foundation that actively mitigates heavy metal and pesticide accumulation risks.

Through our advanced low-temperature extraction and proprietary macroporous resin purification, we successfully isolate the plant's most critical therapeutic compound: Trans-Resveratrol. Standardized to a pharmaceutical-grade purity of ≥98% via HPLC, we simultaneously execute strict impurity controls, reducing anthraquinone derivatives (such as Emodin) to below 0.1% to guarantee gastrointestinal safety. Exhibiting profound efficacy in activating the SIRT1 "longevity" pathway, neutralizing cellular oxidative stress, and supporting cardiovascular health, our fine white-to-off-white powder serves as an indispensable Active Pharmaceutical Ingredient (API) for premium anti-aging nutraceuticals, advanced cardiometabolic formulations, and high-end cosmeceuticals.

Cellular Longevity & Anti-Aging (SIRT1 Activation)

Trans-Resveratrol is the most potent naturally occurring activator of the SIRT1 enzyme (sirtuin 1), often referred to as the "longevity gene." By mimicking the metabolic effects of caloric restriction, it enhances mitochondrial biogenesis and function, actively delaying cellular senescence and age-related functional decline.

Profound Cellular Antioxidant Defense

Functions as a premier, broad-spectrum free-radical scavenger. It actively upregulates the body's endogenous antioxidant defense network-increasing the activity of Superoxide Dismutase (SOD) and Glutathione (GSH)-protecting cellular DNA and endothelial tissues from severe oxidative stress.

Multi-Pathway Anti-Inflammatory Modulation

Aggressively modulates inflammatory cascades by inhibiting the transcription and expression of key pro-inflammatory mediators, primarily the NF-κB pathway, COX-2, and iNOS. This provides robust systemic relief for joint inflammation, dermatitis, and chronic metabolic inflammation.

Cardiometabolic Protection

Demonstrates significant cardioprotective efficacy. By activating the AMPK pathway, it enhances cellular insulin sensitivity and assists in maintaining blood glucose homeostasis. Simultaneously, it inhibits the oxidation of LDL cholesterol, preventing abnormal lipid accumulation within arterial walls.

♦ Precise Active Customization

We strictly tailor the concentration of Trans-Resveratrol (offering custom gradients from 50% up to ≥99% HPLC) to meet your specific therapeutic claims and budgetary requirements for dietary supplement lines.

♦ Traceable Quality Control

Quality is mathematically verifiable. Batch consistency exceeds 99% (Key indicator RSD <1%). Every batch undergoes strict cGMP-certified analysis via HPLC. We provide full COAs, ensuring emodin residues and heavy metals strictly comply with global standards.

♦ Strict Brand Confidentiality

Secure IP protection via NDAs. We offer blind shipping, private label bulk packaging (1kg foil bags to 25kg sterile drums), and full FDA/EU regulatory documentation support for global customs clearance.