Mulberry Leaf Extract
Latin name: Morus alba L
Nicknames: Domestic Mulberry, Jingsang, Yellow Mulberry Leaf
Detection method: HPLC
CAS number 19130-96-2
Active ingredient: Deoxynojirimycin
Product Description: Brown Powder
Product specifications: 1% -10%
Number of mesh: 80 mesh
Product packaging: 1kg/aluminum foil bag; 25kg/cardboard drum
Storage conditions: Sealed and shaded, dry, ventilated, and cool place.
Shelf life: 24 months
Clinical-Grade Mulberry Leaf Extract (1-Deoxynojirimycin / DNJ)
Manufactured by Xi'an Tihealth Biotechnology Co., Ltd.
Xi'an Tihealth is a premier global B2B supplier of highly purified Mulberry Leaf Extract (Morus alba L.). We rigorously source our raw materials from the first to third tender leaves harvested during the late silkworm stage, ensuring an exceptionally high natural accumulation of bioactives while strictly adhering to GAP-certified, heavy-metal-free cultivation standards.
Utilizing our proprietary low-temperature dynamic countercurrent extraction combined with advanced fermentation technologies, we successfully isolate the plant's most critical therapeutic alkaloid: 1-Deoxynojirimycin (DNJ), alongside synergistic flavonoids and polysaccharides. Standardized to a pharmaceutical-grade purity (up to 5% DNJ via HPLC), our highly stable extract exhibits profound clinical efficacy as a natural α-glucosidase inhibitor, delaying carbohydrate absorption and preventing postprandial glucose spikes. It serves as a foundational Active Ingredient for advanced blood-sugar management nutraceuticals, low-GI functional foods, and metabolic wellness formulations.
Technical Data Sheet (TDS) & Analytical Control
| Analysis Item | Target Specification | Result (Typical Batch) | Methodology |
|---|---|---|---|
| Botanical Source | Leaves of Morus alba L. | Verified | Macroscopic ID / TLC |
| 1-Deoxynojirimycin (DNJ) | ≥ 0.4% (Customizable up to 5%) | 0.42% | HPLC-ELSD |
| Total Flavonoids | ≥ 5.0% | 5.8% | UV Spectrophotometry |
| Appearance | Brown-yellow to light green powder | Complies | Visual Assessment |
| Solubility (Water 25°C) | Fully dispersible / soluble | Complies | Aqueous Dispersion |
| Loss on Drying | ≤ 5.0% | 3.2% | Karl Fischer / USP |
| Heavy Metals (Pb, As) | ≤ 1.0 ppm / ≤ 0.5 ppm | < 0.1 ppm / < 0.05 ppm | ICP-MS |
| Microbiology (Total Plate) | ≤ 1000 CFU/g | 120 CFU/g | ISO 4833-1 |
Manufacturing & Processing Excellence
Dynamic Countercurrent Extraction
Standard high-temperature decoctions destroy up to 50% of the active alkaloids. Tihealth utilizes advanced low-temperature dynamic countercurrent extraction. This thermodynamic innovation ensures a ≥95% retention rate of the heat-sensitive 1-Deoxynojirimycin (DNJ) and preserves the structural integrity of the synergistic flavonoids.
Enzymatic Fermentation Protocol
To maximize bioavailability, we subject the raw leaf powder to controlled fermentation using specific cellulase-producing bacteria. This biological process effectively breaks down the rigid cellulose cell walls, vastly improving the extraction yield of intracellular polysaccharides without harsh chemical intervention.
Anti-Caking Molecular Stabilization
DNJ is inherently highly hygroscopic (absorbs moisture rapidly), leading to severe caking in commercial formulas. We deploy a proprietary vacuum freeze-drying and structural stabilization process. This guarantees exceptional flowability and prevents agglomeration for up to 24 months under standard storage conditions.
Evidence-Based Pharmacological Mechanisms
α-Glucosidase Inhibition (Glycemic Control)
The core alkaloid, DNJ, acts as a highly potent, competitive inhibitor of α-glucosidase enzymes in the small intestine. By delaying the enzymatic breakdown of complex carbohydrates into glucose, it actively suppresses postprandial (after-meal) blood sugar spikes, functioning as a primary mechanism for diabetic metabolic management.
Insulin Sensitization & Lipid Regulation
Beyond carbohydrate blocking, the extract demonstrates significant efficacy in reducing cellular insulin resistance. The synergistic action of mulberry polysaccharides and flavonoids helps regulate hepatic lipid metabolism, lowering elevated serum cholesterol and triglyceride levels.
Profound Cellular Antioxidant Defense
Rich in Chlorogenic Acid and Rutin, the extract functions as an aggressive free-radical scavenger (demonstrating rapid DPPH scavenging capabilities). This mitigates oxidative stress on cellular DNA, protecting vascular endothelial cells from damage associated with chronic hyperglycemia.
Adjuvant Weight Management
By moderating the insulin response and preventing excess glucose from converting into adipose (fat) tissue, the extract serves as a highly effective, stimulant-free adjunct for clinical weight management and obesity-prevention formulations.
Industrial Formulation Applications
Glycemic Control Nutraceuticals
The premier botanical API for formulating targeted blood-sugar management capsules, often synergized with Chromium Picolinate or Bitter Melon extract.
Low-GI Functional Foods
Incorporated heavily into the baking industry (added at ~5% concentration) to manufacture low-Glycemic Index (GI) noodles, biscuits, and diabetic-friendly staple foods.
Weight Management Supplements
Utilized as a stimulant-free carbohydrate blocker in chewable diet tablets, meal-replacement powders, and metabolic fitness blends.
Premium Cosmeceuticals
Leveraged for its anti-glycation properties; added to high-end skin-brightening serums and anti-aging face masks (often combined with Niacinamide) to prevent collagen degradation.
Contract Manufacturing & Global Supply Chain
♦ Precise Active Customization
We strictly tailor the concentration of 1-Deoxynojirimycin (from standard 0.4% up to highly concentrated 5.0% HPLC fractions) to perfectly match your specific therapeutic claims and budgetary requirements.
♦ Traceable Quality Control
Quality is mathematically verifiable. Every batch undergoes strict cGMP-certified analysis via HPLC-ELSD. We provide full COAs, ensuring heavy metals, pathogens, and pesticide residues strictly comply with global food and pharmaceutical safety standards.
♦ Strict Brand Confidentiality
Secure IP protection via NDAs. We offer blind shipping, private label bulk packaging (from 1kg foil bags to 25kg sterile drums), and full FDA/EU regulatory documentation support for global customs clearance.
Packaging, Logistics & Secure Payment
Reliable B2B Supply Chain Solutions
We provide pharmaceutical-grade aseptic packaging, efficient global logistics (Air/Sea freight with dual customs clearance), and secure multi-currency payment methods to ensure seamless, oxidation-free cross-border transit for our B2B procurement partners.



Formulator & Procurement FAQ
01. How do you test for the exact DNJ concentration?
Unlike basic gravimetric testing, we utilize High-Performance Liquid Chromatography paired with an Evaporative Light Scattering Detector (HPLC-ELSD). This patented analytical method allows us to specifically isolate and quantify the exact percentage of 1-Deoxynojirimycin (DNJ), ensuring unquestionable potency on your COA.
02. Is this extract completely water-soluble for beverage applications?
Yes. Through advanced macroporous resin purification and high-speed centrifugation, we completely remove heavy insoluble plant fibers and inert waxes. The resulting micro-powder disperses rapidly and clearly in cold water, making it perfect for functional RTD teas and clear beverages.
03. Does the powder suffer from severe caking (hygroscopicity)?
DNJ is naturally highly hygroscopic. However, we employ a proprietary vacuum freeze-drying and molecular stabilization process. When stored properly in its sealed, moisture-barrier packaging, our powder maintains exceptional flowability without agglomeration for up to 24 months.
04. Can you guarantee the product is free from heavy metals and pesticides?
Yes. We proactively mitigate this risk by sourcing exclusively from unpolluted, GAP-certified ecological zones. Every batch is verified via ICP-MS and GC-ECD to ensure Lead (Pb) remains ≤ 1.0 ppm and pesticide residues are entirely absent, conforming to stringent FDA safety standards.
05. What is the Minimum Order Quantity (MOQ) and lead time?
Our standard MOQ for mass production is 25kg, packed in heavy-duty cardboard drums lined with double sterile, nitrogen-flushed bags to prevent moisture ingress. We also supply 1kg foil bags for pilot manufacturing and R&D trials. Standard dispatch is within 7-10 days.
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