Grapefruit Extract
Latin name: Apigenin
English name: Apigenin powder
Extraction source: Grapefruit extract
Product specifications: 98%
Detection method: HPLC/UV
Appearance: Light yellow powder
Mesh size: filtered through 80 mesh.
Packaging method: 1KG aluminum foil bag, 25KG cardboard drum
Storage conditions: Sealed and shaded, stored in a dry, cool, well ventilated place.
Shelf life: 24 months
Pharmaceutical-Grade Grapefruit Extract (Naringin / Apigenin)
Manufactured by Xi'an Tihealth Biotechnology Co., Ltd.
Xi'an Tihealth is a premier global B2B manufacturer of highly purified Grapefruit Extract (Citrus paradisi Macfadyen). We rigorously source our raw materials from premium, heavy-metal-free citrus orchards. By utilizing the nutrient-dense peels and seeds, we ensure an exceptionally high natural accumulation of vital therapeutic bioactives while strictly adhering to GAP-certified cultivation standards.
Through our advanced macroporous resin separation and proprietary biocatalytic technologies, we successfully isolate the plant's core flavonoid: Naringin, and offer precision enzymatic conversion to produce high-value Apigenin. Standardized to pharmaceutical-grade purities (≥98% via HPLC), our refined extracts overcome traditional solubility challenges. Renowned for their profound clinical efficacy in neutralizing oxidative stress, modulating inflammatory cytokines, and crossing the blood-brain barrier for neuroprotection, our products serve as foundational Active Pharmaceutical Ingredients (APIs) for advanced cognitive supplements, targeted anti-inflammatory nutraceuticals, and premium anti-aging cosmetics.
Technical Data Sheet (TDS) & Analytical Control
| Analysis Item | Target Specification | Result (Typical Batch) | Methodology |
|---|---|---|---|
| Botanical Source | Peels/Seeds of Citrus paradisi | Verified | Macroscopic ID |
| Naringin / Apigenin Purity | ≥ 98.0% (Customizable) | 98.6% | HPLC |
| Appearance | Off-white to light yellow powder | Complies | Visual Assessment |
| Melting Point (Apigenin) | 345°C - 350°C | 347.5°C | Capillary Method |
| Loss on Drying | ≤ 5.0% | 2.8% | Karl Fischer / USP |
| Residue on Ignition | ≤ 1.0% | 0.4% | USP <281> |
| Heavy Metals (Pb, As) | ≤ 2.0 ppm / ≤ 1.0 ppm | < 0.5 ppm / < 0.1 ppm | ICP-MS |
| Microbiology (Total Plate) | ≤ 1000 CFU/g | < 100 CFU/g | ISO 4833-1 |
Manufacturing & Processing Excellence
Advanced Biocatalytic Conversion
While Naringin is directly extracted from grapefruit, high-value Apigenin is naturally scarce. Tihealth utilizes state-of-the-art enzymatic bioconversion. By using Naringin as a botanical precursor and reacting it under precise alkaline conditions, we sustainably synthesize ≥98% pure Apigenin without relying on exhaustive chemical synthesis.
Debittering & Purification
Citrus extracts typically carry intense bitterness from limonin compounds. We deploy sophisticated macroporous resin chromatography to selectively adsorb and eliminate these bitter principles. The resulting extract offers a clean, neutral profile, greatly expanding its applicability in functional foods and oral suspensions.
Zero Toxic Solvent Residues
Neurological and cardiovascular formulations demand absolute purity. We strictly abandon harsh industrial solvents, utilizing only a food-grade Ethanol-Water system for primary extraction. Rigorous vacuum evaporation ensures solvent residues remain virtually undetectable (<50ppm).
Evidence-Based Pharmacological Mechanisms
Profound Neuroprotection (Blood-Brain Barrier Penetration)
Apigenin is unique among flavonoids due to its ability to efficiently cross the blood-brain barrier. Clinical research indicates it acts as a potent neuroprotective agent, modulating neuro-inflammation and demonstrating significant potential as an adjuvant therapy in slowing the progression of neurodegenerative conditions like Alzheimer's.
Systemic Antioxidant Defense
The Naringin/Apigenin matrix functions as an aggressive free-radical scavenger. It actively upregulates endogenous antioxidant enzymes (such as SOD and Glutathione), significantly reducing oxidative stress on cellular DNA and delaying generalized cellular senescence (aging).
Broad-Spectrum Anti-Inflammatory Modulation
Effectively mitigates chronic inflammation by directly inhibiting the NF-κB signaling pathway. It drastically reduces the expression of pro-inflammatory mediators (like COX-2, TNF-α, and interleukins), providing systemic relief for inflammatory joint conditions and dermal irritation.
Cardiovascular Health & Lipid Regulation
Naringin demonstrates strong efficacy in metabolic regulation. It assists in lowering serum triglyceride levels, improving endothelial function, and promoting vasodilation, thereby offering robust nutritional support against atherosclerosis and hypertension.
Industrial Formulation Applications
Neurological Nutraceuticals
The premier botanical API (Apigenin) for formulating cognitive-enhancement capsules, memory-support tablets, and stress-reduction sleep aids.
Pharmaceutical R&D
Extensively utilized in clinical research as an intermediate for developing targeted anti-viral medications, anti-tumor adjuvants, and cardiovascular treatments.
Premium Cosmeceuticals
Due to its potent antioxidant capacity and micro-circulation benefits, it is heavily formulated into high-end anti-dark-circle eye creams and anti-aging serums.
Natural Food Additives
Functions as a broad-spectrum botanical antimicrobial and antioxidant, serving as a clean-label preservative to naturally extend the shelf life of functional foods.
Contract Manufacturing & Global Supply Chain
♦ Precise Active Customization
We do not just supply raw Naringin. We empower B2B buyers to select their specific active derivative (Naringin or converted Apigenin) at purities reaching up to 98% HPLC, tailored for exact therapeutic claims.
♦ Traceable Quality Control
Quality is mathematically verifiable. Every batch undergoes strict cGMP-certified analysis via HPLC. We provide full COAs, ensuring heavy metals, pathogens, and pesticide residues strictly comply with stringent USP/EP and FDA standards.
♦ Strict Brand Confidentiality
Secure IP protection via NDAs. We offer blind shipping, private label bulk packaging (from 1kg foil bags to 25kg sterile drums), and full regulatory documentation support for global customs clearance.
Packaging, Logistics & Secure Payment
Reliable B2B Supply Chain Solutions
We provide pharmaceutical-grade aseptic packaging, efficient global logistics (Air/Sea freight with dual customs clearance), and secure multi-currency payment methods to ensure seamless, oxidation-free cross-border transit for our B2B procurement partners.
Formulator & Procurement FAQ
01. What is the relation between Grapefruit Extract, Naringin, and Apigenin?
Naringin is the primary flavonoid naturally abundant in grapefruit peels. Because Apigenin is naturally scarce, we utilize advanced biocatalytic (enzymatic) technology to convert Naringin extracted from grapefruit into high-value, high-purity Apigenin, providing a sustainable, scalable API source.
02. Is the extract highly soluble in water?
High-purity Apigenin is inherently lipophilic and almost insoluble in water, though it dissolves readily in dilute alkali or hot ethanol. To overcome this in liquid formulations, we offer structure-optimized derivatives (introducing sulfonic acid groups) or liposomal encapsulation to drastically increase water solubility.
03. Does the Grapefruit Extract retain its characteristic bitter taste?
No. Natural Naringin is extremely bitter. We deploy sophisticated macroporous resin chromatography to selectively debitter the extract, ensuring a clean, neutral profile that will not negatively impact the flavor of your functional foods or oral suspensions.
04. Are furanocoumarins (which cause drug interactions) removed?
Yes. The furanocoumarins in grapefruit are infamous for interacting with the CYP3A4 enzyme. Our targeted purification process explicitly isolates the flavonoid fractions (Naringin/Apigenin) while systematically eliminating these problematic compounds, ensuring a safer pharmacological profile.
05. What is the Minimum Order Quantity (MOQ) and lead time?
Our standard MOQ for mass production is 25kg, packed in heavy-duty cardboard drums lined with double sterile, nitrogen-flushed bags to prevent oxidation. We also supply 1kg foil bags for pilot manufacturing and R&D trials. Standard dispatch is within 7-10 days.
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