Polysaccharide Krestin
Latin name: Coriolus Versicolor Polysaccharide
Alias: Coriolus versicolor, also known as Coriolus versicolor, Coriolus versicolor, Coriolus versicolor, Coriolus versicolor, Coriolus versicolor
Extraction source: mycelia of Coriolus versicolor
Product specifications: Coriolus Versicolor Polysaccharide 10%-50% various specifications
Detection method: UV
Product properties: yellow powder
Packaging method: 25kg/cardboard barrel, 1kg/aluminum foil bag,
Storage conditions: sealed and shaded, dry, cool and well ventilated
Shelf life: 24 months of Coriolus Versicolor Polysaccharide
Clinical-Grade Polysaccharide Krestin (PSK / Coriolus versicolor Extract)
Manufactured by Xi'an Tihealth Biotechnology Co., Ltd.
Xi'an Tihealth is a premier global B2B manufacturer of highly purified Polysaccharide Krestin (PSK), derived from the Turkey Tail mushroom (Coriolus versicolor / Trametes versicolor). To ensure absolute consistency and eliminate the heavy metal risks associated with wild fungal foraging, we utilize advanced deep-submerged liquid fermentation of rigorously screened, high-potency mycelial strains.
Moving beyond standard hot-water decoctions, our facility employs a sophisticated extraction cascade-incorporating specialized enzymatic deproteinization (Sevag method) and multi-stage dialysis. This isolates the highly specific protein-bound polysaccharide complex (glycopeptide) characterized by a β-glucan main chain and an average molecular weight of ~100,000 Daltons. Standardized to pharmaceutical tolerances (≥35% Total Polysaccharides; ≥15% Peptides), our PSK is internationally recognized for its profound immunomodulatory and hepatoprotective properties. It serves as a foundational Active Pharmaceutical Ingredient (API) for clinical oncology-support nutrition, advanced immune-fortification capsules, and targeted longevity supplements.
Technical Data Sheet (TDS) & Analytical Control
| Analysis Item | Target Specification | Result (Typical Batch) | Methodology |
|---|---|---|---|
| Botanical Source | Mycelium of Coriolus versicolor | Verified | Strain Identification |
| Total Polysaccharides | ≥ 35.0% | 38.5% | Phenol-Sulfuric Acid |
| Peptide Content | ≥ 15.0% | 18.2% | Kjeldahl Nitrogen |
| β-Glucan Fraction | ≥ 20.0% | 23.1% | Enzymatic / HPLC |
| Appearance | Brown-yellow fine powder | Complies | Visual Assessment |
| Solubility | Soluble in warm water | Complies | Aqueous Dispersion |
| Loss on Drying | ≤ 8.0% | 5.2% | Karl Fischer / USP |
| Heavy Metals (Pb, As) | ≤ 2.0 ppm / ≤ 1.0 ppm | < 1.0 ppm / < 0.5 ppm | ICP-MS |
| Microbiology (Total Plate) | ≤ 1000 CFU/g | < 100 CFU/g | ISO 4833-1 |
Manufacturing & Processing Excellence
Deep Submerged Fermentation
Wild harvesting of Coriolus versicolor results in severe batch-to-batch inconsistency and environmental contamination. Tihealth utilizes advanced 26-30°C deep submerged liquid fermentation in sterile bioreactors. This optimizes the carbon-nitrogen ratio, producing a consistent, exceptionally pure mycelial biomass.
Glycopeptide Isolation (Sevag Method)
Standard mushroom powders destroy delicate proteins. To isolate the critical Polysaccharide-K (a protein-bound structure), we employ precise chloroform/n-butanol deproteinization (the Sevag method). This strips away unbound, inert proteins while perfectly preserving the β-glucan main chains and their active peptide side-chains.
Advanced Membrane Dialysis
To guarantee the specific molecular weight profile (~100,000 Daltons) necessary for clinical efficacy, the extract undergoes rigorous 0.22μm membrane filtration and dialysis. This removes low-molecular-weight sugars and impurities, resulting in a highly potent, instantly soluble powder.
Evidence-Based Pharmacological Mechanisms
Profound Immunomodulation (Macrophage Activation)
The unique protein-bound β-glucan structure of PSK acts as a potent biological response modifier. It actively binds to Toll-like receptors on immune cells, dramatically enhancing the phagocytic index of macrophages and accelerating T-cell and Natural Killer (NK) cell proliferation rates without triggering hyper-inflammation.
Oncology Adjuvant Support
Supported by decades of clinical literature in Japan and globally, PSK is utilized to mitigate the severe immunosuppressive effects of standard radiotherapy and chemotherapy. It assists in stabilizing white blood cell counts, reducing organ toxicity, and improving the overall quality of life during clinical recovery protocols.
Hepatoprotective (Liver Shield) Action
Demonstrates significant protective effects against hepatic damage. By upregulating endogenous antioxidant enzymes and suppressing pro-inflammatory pathways in the liver, PSK aids in lowering elevated transaminase levels and offers adjuvant support against viral hepatic challenges.
Systemic Antioxidant & Anti-Fatigue
Beyond specific immune activation, the glycopeptide complex functions as an aggressive free-radical scavenger. It protects cellular DNA from oxidative stress, improving systemic energy metabolism and reducing physiological fatigue in compromised or aging populations.
Industrial Formulation Applications
Clinical Adjuvant Nutraceuticals
The core Active Pharmaceutical Ingredient (API) for formulating advanced immune-recovery capsules and specialized medical foods for post-operative patients.
Daily Immune-Support Supplements
Extensively utilized in preventive health formulas, geriatric vitality tablets, and hepatoprotective (liver care) dietary complexes.
Pharmaceutical R&D
Serves as a highly standardized, clinically backed biological intermediate for researchers investigating targeted anti-viral and oncology-support therapeutics.
Premium Animal Nutrition
Formulated into high-end veterinary supplements to boost innate immunity, promote growth, and support disease resistance in agriculture and companion animals.
Contract Manufacturing & Global Supply Chain
♦ Precise Active Customization
We strictly tailor the extraction process to meet your specific clinical targets, ensuring the exact Protein-to-Polysaccharide ratio required for your specialized dietary supplement or medical food formulations.
♦ Traceable Quality Control
Quality is mathematically verifiable. Every batch undergoes strict cGMP-certified analysis via enzymatic HPLC and Kjeldahl methods. We provide full COAs, ensuring heavy metals and pathogens strictly comply with global pharmacopeial standards.
♦ Strict Brand Confidentiality
Secure IP protection via NDAs. We offer blind shipping, private label bulk packaging (from 1kg foil bags to 25kg sterile drums), and full FDA/EU regulatory documentation support for global customs clearance.
Packaging, Logistics & Secure Payment
Reliable B2B Supply Chain Solutions
We provide pharmaceutical-grade aseptic packaging, efficient global logistics (Air/Sea freight with dual customs clearance), and secure multi-currency payment methods to ensure seamless, oxidation-free cross-border transit for our B2B procurement partners.
Formulator & Procurement FAQ
01. How is PSK structurally different from standard mushroom polysaccharides?
Standard mushroom extracts contain simple polysaccharides (mostly alpha-glucans). PSK is a highly complex glycopeptide-a protein-bound polysaccharide. It consists of a specific β-glucan main chain covalently linked to active peptide side-chains (typically 15-38% protein), which is crucial for its profound receptor-binding and immunomodulatory efficacy.
02. Is this extract completely water-soluble for beverage applications?
Yes. Through rigorous Sevag deproteinization (removing inert structural proteins) and micro-membrane dialysis, we completely remove heavy insoluble fungal chitins. The resulting micro-powder disperses rapidly and clearly in warm water, making it perfect for functional liquid formulations without causing sedimentation.
03. Does the fermentation process use toxic chemical solvents?
No. We rely on a highly controlled submerged liquid fermentation system using sterile, food-grade media. The subsequent extraction utilizes purified water and ethanol protocols, combined with vacuum evaporation, ensuring residual solvents remain strictly below all global pharmaceutical safety limits.
04. Can you guarantee the exact active content from batch to batch?
Absolutely. Because we use controlled bioreactor fermentation rather than wild-harvested mushrooms, we eliminate environmental variables. Every batch is rigorously quantified using HPLC (for β-Glucans) and Kjeldahl methods (for Peptides), providing verifiable proof of potency on every COA.
05. What is the Minimum Order Quantity (MOQ) and lead time?
Our standard MOQ for mass production is 25kg, packed in heavy-duty cardboard drums lined with double sterile, nitrogen-flushed bags to prevent oxidation and moisture ingress. We also supply 1kg foil bags for pilot manufacturing and clinical R&D trials. Standard dispatch is within 7-10 days.
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