Cis-Resveratrol | CAS 61434-67-1 | > 98% HPLC Analytical Standard
CAS Number: 61434-67-1
Appearance: Light yellow or light brown powder
Key Feature: High fluorescence quantum yield (260nm)
Cis-Resveratrol Analytical Reference Standard (API Impurity Marker)
Manufactured by Xi'an Tihealth Biotechnology Co., Ltd. (R&D Division)
Xi'an Tihealth Biotechnology provides forensic-grade Cis-Resveratrol ((Z)-Resveratrol) explicitly designed as an Analytical Reference Standard for advanced Quality Assurance (QA) and R&D laboratories. While Trans-Resveratrol is the bioactive molecule sought after in the longevity sector, it is highly unstable. Exposure to UV light causes rapid photo-isomerization into the biologically inert Cis-isomer. Therefore, accurately quantifying the presence of Cis-Resveratrol is the absolute gold standard for determining the degradation, shelf-life stability, and manufacturing integrity of commercial Trans-Resveratrol batches.
Synthesizing and isolating high-purity cis-isomers is notoriously difficult due to their transient molecular nature. Tihealth utilizes targeted photo-conversion followed by Preparative High-Performance Liquid Chromatography (Prep-HPLC) to capture and stabilize the cis-geometry. Standardized to a strict purity of ≥ 98.0% and supplied with full spectral data (1H-NMR, 13C-NMR, LC-MS), our Cis-Resveratrol reference standard empowers pharmaceutical formulation labs, third-party testing agencies, and university research institutes to precisely calibrate their chromatographic instruments and audit their supply chains with mathematical certainty.
Technical Data Sheet (TDS) & Analytical Control
| Analytical Parameter | Target Specification | Result (Typical Batch) | Methodology |
|---|---|---|---|
| IUPAC Chemical Name | (Z)-5-[2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol | Verified | Structural Match |
| Assay (Purity) | ≥ 98.0% (Calibration Grade) | 98.5% | HPLC-UV |
| CAS Registry Number | 61434-67-1 | Confirmed | - |
| Molecular Formula | C14H12O3 | Matches Profile | MW: 228.24 g/mol |
| Appearance | White to off-white powder or oil (State dependent) | Complies | Visual Assessment |
| Solubility Profile | Soluble in DMSO, Ethanol, Methanol | Complies | Solvent Assessment |
| Spectral Validation | 1H-NMR, 13C-NMR, LC-MS provided | Spectra Attached | Nuclear Magnetic Resonance |
| Storage Conditions | Store at -20°C in dark, dry conditions | Complies | Stability Protocol |
Laboratory Isolation & Validation Process
Controlled Photo-Isomerization
Cis-Resveratrol rarely occurs in significant quantities in living botanical tissue. To generate high-fidelity reference materials, our R&D team exposes ultra-pure trans-resveratrol solutions to specific wavelengths of ultraviolet (UV) radiation under tightly controlled, inert atmospheric parameters to induce geometric photo-isomerization.
Preparative HPLC Fractionation
Separating the newly formed cis-isomer from the remaining trans-isomer requires extreme precision. We utilize advanced Preparative High-Performance Liquid Chromatography (Prep-HPLC). By identifying the distinct retention times, our chemists expertly collect and consolidate the precise cis-resveratrol fractions.
Full Spectral Verification (NMR)
Purity testing alone is insufficient for calibration standards. We provide absolute structural confirmation for every lot. Our analytical documentation includes High-Resolution Mass Spectrometry (HRMS) alongside 1H and 13C Nuclear Magnetic Resonance (NMR) spectra to irrefutably prove the (Z)-stereochemistry of the molecule.
Analytical & Quality Assurance Applications
Chromatographic Instrument Calibration
In pharmaceutical manufacturing, distinguishing between the active trans-isomer and the inactive cis-isomer is a regulatory requirement. Tihealth's Cis-Resveratrol acts as the primary reference standard for calibrating HPLC/UPLC detection baselines. It enables laboratory technicians to accurately plot retention times and calculate the exact contamination ratios within commercial batches.
Degradation & Shelf-Life Auditing
Trans-resveratrol is highly vulnerable to degradation during encapsulation, shelf storage, and distribution. Formulators utilize our cis-isomer standard during accelerated stress testing (temperature and light chambers) to map the isomerization trajectory. This data is critical for assigning accurate expiry dates and verifying the efficacy of opaque packaging configurations.
In-Vitro Pharmacological Benchmarking
While universally considered inactive regarding longevity (SIRT1) pathways, some niche R&D sectors investigate the distinct anti-inflammatory behaviors of the cis-isomer on specific macrophage responses (like NADPH oxidase inhibition). It serves as an essential negative control or comparative benchmark in advanced cell-culture assays.
Supply Chain Fraud Detection
Low-tier suppliers often hide improper extraction methods (such as boiling in direct sunlight) by omitting cis-isomer data on their COAs. Armed with our reference standard, procurement QA teams can independently audit incoming shipments to detect compromised or severely photo-degraded raw materials before they enter the manufacturing line.
Targeted R&D and Testing Sectors
Contract Testing Laboratories
Essential for independent third-party certification agencies (like NSF or Eurofins) to validate the true bio-active label claims of commercial longevity supplements on the open market.
Nutraceutical In-House QA Teams
Utilized by formulation chemists to ensure that encapsulation machines, blending tanks, and high-heat sterilization protocols are not accidentally destroying the active trans-resveratrol ingredient.
Academic & Medical Institutions
Applied in university biochemistry departments conducting research on the pharmacokinetics, metabolic pathways, and structural degradation models of natural stilbenoids.
Cosmetic Formulation Scientists
Used to test the photo-stability of high-end anti-aging serums. If the trans-resveratrol formulation turns brown due to UV exposure, the cis-isomer standard helps quantify the extent of the failure.
Laboratory Supply & Technical Support
♦ Milligram to Gram Sizing
Unlike bulk botanical extracts, reference standards require micro-precision. We supply Cis-Resveratrol in tailored analytical configurations ranging from 10mg, 50mg, up to 1-gram precision amber vials for intensive laboratory operations.
♦ Comprehensive Spectral Data
A standard is useless without verification. Every vial of Tihealth's Cis-Resveratrol is accompanied by an extensive data package, including verified HPLC chromatograms, HRMS mass reports, and detailed NMR spectroscopy profiles.
♦ Cold-Chain Global Delivery
To prevent any structural degradation during international transit, our reference standards are shipped under stringent cold-chain protocols (dry ice or -20°C controlled environments) to guarantee the molecule arrives with its geometry flawlessly intact.
Packaging, Logistics & Secure Payment
Reliable B2B Supply Chain Solutions
We provide pharmaceutical-grade aseptic packaging, efficient global logistics (Air/Sea freight with dual customs clearance), and secure multi-currency payment methods to ensure seamless, oxidation-free cross-border transit for our B2B procurement partners.
Laboratory Procurement FAQ
01. Can Cis-Resveratrol be formulated into longevity supplements?
No. Cis-resveratrol is biologically inert regarding SIRT1 activation and human longevity pathways. It is strictly utilized as an Analytical Reference Standard to help formulation laboratories identify degradation levels and impurity profiles within their Trans-Resveratrol product batches.
02. In what solvents should I prepare my stock solutions for HPLC calibration?
Cis-Resveratrol is highly soluble in organic solvents. We recommend preparing standard stock solutions (e.g., 10 mM) using high-grade Dimethyl Sulfoxide (DMSO) or absolute Ethanol. It possesses extremely poor solubility in pure PBS (phosphate-buffered saline) or water.
03. Are there trace amounts of Trans-Resveratrol in this standard?
Due to the aggressive tendency of the molecule to revert toward equilibrium, even highly purified cis-isomers may contain minor traces (typically 1-2%) of the trans-isomer. Our COA precisely details the exact purity and isomeric ratio of every specific lot shipped.
04. What are the strict storage conditions required upon delivery?
To maintain absolute geometric integrity, the vials must be stored in the dark at -20°C (long-term) or 0-4°C (short-term). Exposure to ambient UV light or elevated room temperatures will accelerate spontaneous back-conversion into the trans-isomer, ruining the calibration baseline.
05. How do I order mg or gram scale quantities for my university lab?
Tihealth actively supports global academic research and QA initiatives. You can easily request a quote via our contact form for precise laboratory volumes (10mg, 50mg, 100mg, or 1g vials). All shipments include comprehensive SDS and analytical spectra documentation.
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