Trans-Resveratrol Powder | CAS 501-36-0 | ≥ 98% HPLC Botanical Extract
Latin name: Trans-Resveratrol
Product source: 100% Biogenic Fermentation
Content specification: 98% / 99% HPLC
CAS number: 501-36-0
Testing method: HPLC
Active ingredient: Trans-Resveratrol
Product packaging: 1kg/bag; 25kg/drum
Product storage: Sealed, cool and dry place, avoid light
Shelf life: 24 months
Pharmaceutical-Grade Trans-Resveratrol API (100% Biogenic)
Manufactured by Xi'an Tihealth Biotechnology Co., Ltd.
Xi'an Tihealth Biotechnology is a premier global B2B manufacturer of forensic-grade Trans-Resveratrol derived from authentic Polygonum cuspidatum (Giant Knotweed) roots. The global longevity market is plagued by low-tier commodities that conceal toxic levels of Emodin (a severe gastrointestinal irritant) and are frequently adulterated with cheap, petrochemical-derived synthetic isolates. Tihealth shatters these supply chain illusions.
Through advanced macroporous resin adsorption chromatography, we selectively trap and isolate Emodin, suppressing its threshold strictly below 0.1% to guarantee absolute gastrointestinal safety. Furthermore, every batch is verified via Carbon-14 (C14) Radiocarbon dating to prove 100% biogenic (plant-based) origin, completely free from fossil-fuel synthetic spiking. Processed entirely in climate-controlled darkrooms to prevent photo-isomerization into the inactive "cis" form, and micronized for superior liposomal bioavailability, Tihealth's Trans-Resveratrol API is the definitive, risk-free molecular engine for premium anti-aging formulations, SIRT1 activators, and cardiovascular cosmeceuticals.
Technical Data Sheet (TDS) & Analytical Control
| Forensic Audit Parameter | Target Specification | Result (Typical Batch) | Methodology |
|---|---|---|---|
| Biological Source | Roots of Polygonum cuspidatum | Verified | Macroscopic / DNA |
| Assay (Trans-Resveratrol) | ≥ 98.0% (Dry Basis) | 98.8% | HPLC-UV |
| Emodin Toxicity Level | ≤ 0.1% (Safe for GI tract) | 0.04% | HPLC |
| Biobased Content (C14) | 100% Natural (Zero Synthetic) | Complies | ASTM D6866 / AMS |
| Cis-Isomer Impurity | ≤ 0.5% | 0.15% | Darkroom Process Control |
| CAS / Molecular Formula | 501-36-0 / C14H12O3 | Matches Profile | MW: 228.24 g/mol |
| Appearance & Particle Size | Off-white to white micro-powder; D90 < 5μm | Complies | Laser Diffraction |
| Heavy Metals (Pb, As) | ≤ 10.0 ppm / ≤ 1.0 ppm | < 2.0 ppm / < 0.1 ppm | ICP-MS |
Advanced Isolation & Quality Control Protocol
Resin Emodin Purging
Standard ethanol precipitation completely fails to separate emodin (a violent purgative) from the resveratrol lattice. We deploy multi-stage Macroporous Resin Adsorption Chromatography. By manipulating the precise polarity differential between the stilbene backbone and anthraquinone impurities, we actively purge emodin to ≤ 0.1%, ensuring zero GI distress for your end-consumers.
Darkroom Isomer Protection
Trans-Resveratrol is highly photosensitive. Ambient UV light instantly triggers photo-isomerization, converting the active molecule into biologically inert Cis-Resveratrol. Tihealth operates all extraction, isolation, and drying phases under strict darkroom conditions to suppress cis-isomer contamination below 0.5%, preserving absolute therapeutic potency.
Ultra-High-Pressure Micronization
Native 80-mesh crystalline aggregates present terrible dissolution kinetics in the human gut. We execute specialized ultra-high-pressure micronization, shrinking the particle size distribution to a precise D90 < 5μm. This massive expansion of specific surface area is crucial for driving rapid systemic absorption and facilitating advanced liposomal emulsification.
Evidence-Based Mechanisms of Cellular Action
SIRT1 Pathway Activation (Longevity Gene)
Trans-Resveratrol is scientifically established as a potent allosteric activator of SIRT1 (Sirtuin 1), a critical enzyme linked to the delay of cellular senescence. By mimicking the biological effects of caloric restriction, it modulates DNA repair mechanisms, suppresses inflammatory cascades, and fundamentally extends cellular lifespans.
Mitochondrial Biogenesis (AMPK Activation)
By activating the AMPK (AMP-activated protein kinase) pathway, it directly stimulates the generation of new, highly efficient mitochondria within muscle and organ tissues. This significantly enhances endogenous ATP (energy) production, combating age-related metabolic decline and chronic fatigue.
Cardiovascular Endothelial Protection
It exhibits profound cardioprotective activity by upregulating endothelial nitric oxide synthase (eNOS), which facilitates vasodilation and healthy blood flow. Furthermore, it actively inhibits the oxidation of low-density lipoproteins (LDL) and prevents platelet aggregation, structurally defending against atherosclerosis.
Intracellular ROS Scavenging
Operating as a formidable polyphenol, it readily crosses cellular membranes to aggressively neutralize Reactive Oxygen Species (ROS). This mechanism protects lipid membranes, proteins, and nuclear DNA from cumulative environmental and UV-induced oxidative stress, forming the basis of its cosmeceutical efficacy.
Industrial Formulation Applications
Longevity & Anti-Aging Supplements
The foundational API for premium dietary capsules and NAD+ boosting stacks designed to activate SIRT1 pathways and promote systemic cellular rejuvenation.
Liposomal & Sublingual Delivery
Our ultra-micronized D90 < 5μm specification is explicitly engineered for seamless integration into advanced liposomal emulsions and sublingual drops to bypass first-pass liver metabolism.
Premium Anti-Aging Cosmeceuticals
Dissolved in organic polyols (like propanediol), it acts as a high-end active dermal conditioner in brightening serums to protect fibroblasts from UV photoaging and collagen degradation.
Cardiovascular Medical Foods
Formulated into clinical adjuvant therapies and functional regimens targeted at managing endothelial health, reducing LDL oxidation, and supporting microvascular circulation.
Contract Manufacturing & Forensic Auditing
♦ C14 Isotope Authentication
Protect your brand from regulatory prosecution. Routine HPLC cannot detect petrochemical adulteration. Tihealth mandates strict Carbon-14 (C14) Radiocarbon dating to guarantee our API is 100% biogenic, yielding a flawless natural label claim.
♦ Complete Emodin Safety
Never risk consumer GI distress. Unlike crude extracts carrying up to 2% toxic Emodin, our resin purification mathematically suppresses this purgative compound below 0.1%, ensuring absolute gastrointestinal safety for high-dose regimens.
♦ Cold-Chain Commercial Fulfillment
We specialize in global botanical logistics. To halt oxidative degradation, our bulk shipments are vacuum-sealed in dark foil drums and stored under strict climate-controlled conditions (2-8°C) until dispatch, providing full CTD/DMF technical dossiers.
Packaging, Logistics & Secure Payment
Reliable B2B Supply Chain Solutions
We provide pharmaceutical-grade aseptic packaging, efficient global logistics (Air/Sea freight with dual customs clearance), and secure multi-currency payment methods to ensure seamless, oxidation-free cross-border transit for our B2B procurement partners.
Formulator & Procurement FAQ
01. Why is Polygonum cuspidatum preferred over red grape extracts for bulk manufacturing?
Red grapes contain negligible amounts of trans-resveratrol (typically <1%). Attempting to isolate pure 98% crystalline resveratrol from grapes is economically catastrophic for bulk API requirements. Polygonum cuspidatum (Giant Knotweed) roots naturally concentrate massive biological yields of the stilbene molecule, serving as the only commercially viable, sustainable biomass for industrial anti-aging supplementation.
02. What causes high-purity resveratrol powder to transition to a brown color?
Clinical-grade trans-resveratrol API must present as a pale off-white to pristine white fine powder. If your raw material shifts toward a dark tan or brown hue upon receipt, it signals intense oxidative degradation or photo-isomerization into the inactive "cis" form due to poor manufacturing controls. Tihealth entirely prevents this via darkroom processing and vacuum sealing.
03. How do formulators introduce this lipophilic powder into liquid or cosmetic lines?
Because trans-resveratrol is strongly hydrophobic, chemists must avoid dumping raw crystals directly into water-based bases. Our ultra-micronized powder (D90 < 5μm) is explicitly engineered to be seamlessly dissolved in organic polyols (e.g., propanediol, propylene glycol) or integrated via liposomal emulsification loops before serum formulation.
04. Does Tihealth guarantee compliance with European and US Pharmacopoeia limits?
Yes. As a global API manufacturer operating under strict ISO9001:2015 frameworks, we screen every batch via ICP-MS and GC-MS/MS. We guarantee that heavy metals (Pb, As, Cd, Hg) and over 400 agricultural pesticide compounds strictly clear the maximum residue limits (MRL) enforced by USP, EP, and California Proposition 65 monographs.
05. What is the Minimum Order Quantity (MOQ) and lead time?
Our standard MOQ for mass commercial production is 25kg, securely packed in heavy-duty commercial drums lined with sterile, moisture-proof dark foil bags. We also supply 1kg bespoke sample sizes for pilot manufacturing and stability trials. Standard global dispatch is within 7-10 days.
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