Lion’s Mane Mushroom Extract
Latin name: Hericium erinaceus Extract
Plant source: Lion's mane mushroom
Content specification: 10% -50% polysaccharides
Testing method: UV
Active ingredients: β - glucans, Hericenones, Erinacines, etc
Number of mesh: 120 mesh
Appearance: Fine powder ranging from brownish yellow to light brown in color; Easy to dissolve in water; Slightly characteristic mushroom odor
Product Usage: Dietary Supplement, Functional Food Additive, Skincare Field
Product packaging: 1KG/aluminum foil bag; 25KG/cardboard drum
Product storage: Store in a dry and cool place, away from sunlight and high temperatures
Shelf life: 24 months
Plant source: brownish yellow to light brown fine powder; Easy to dissolve in water; Slightly characteristic mushroom odor
Clinical-Grade Lion's Mane Extract (Full-Spectrum Nootropic API)
Manufactured by Xi'an Tihealth Biotechnology Co., Ltd.
As a premier B2B manufacturer of neuro-pharmacological botanical ingredients, Xi'an Tihealth supplies industrial-scale, highly purified Lion's Mane Extract (Hericium erinaceus). We have shattered the industry's most critical technological bottleneck: standard fruiting body extracts lack Erinacines, while cheap "mycelium-on-grain" biomass is heavily adulterated with up to 70% inactive starch (α-glucans). Tihealth solves this by deploying a sophisticated Full-Spectrum Biphasic Extraction Protocol.
First, we cultivate ultra-pure fungal mycelium via advanced Submerged Liquid Fermentation, ensuring absolute zero grain substrate contamination. We then mathematically combine this Erinacine-rich mycelium extract with the neuro-stimulating Hericenones and immunomodulating β-Glucans extracted from mature, indoor-cultivated fruiting bodies. This dual-standardized Active Pharmaceutical Ingredient (API) delivers low-molecular-weight cyathane diterpenoids clinically proven to cross the Blood-Brain Barrier (BBB) and directly catalyze Nerve Growth Factor (NGF) synthesis. Exhibiting flawless aqueous solubility and an undetectable solvent residue profile, our extract is the ultimate biological asset for elite nootropic formulations, memory-support capsules, and neuro-regenerative clinical R&D.
Technical Data Sheet (TDS) & Analytical Control
| Analysis Item | Target Specification | Result (Typical Batch) | Methodology |
|---|---|---|---|
| Biological Source | Liquid Fermented Mycelium & Fruiting Body (H. erinaceus) | Verified | DNA Barcoding / Microscopic |
| Macromolecular β-Glucans | ≥ 30.0% (Up to Custom 50%) | 32.8% | Megazyme K-YBGL / UV |
| Targeted Diterpenoids | Standardized Erinacines & Hericenones | Conforms to Spec | HPLC-MS/MS |
| α-Glucan (Starch Filler) | ≤ 5.0% (Zero Grain Substrate) | < 2.0% | Iodine Test / Enzymatic |
| Appearance & State | Brown/tan homogeneous micro-powder | Complies | Visual Assessment |
| Aqueous Dynamics | 100% soluble without coagulation | Complies | Solvent Assessment |
| Loss on Drying | ≤ 6.0% | 4.1% | Karl Fischer / USP <731> |
| Heavy Metals (Pb, As) | ≤ 2.0 ppm / ≤ 1.0 ppm | < 0.5 ppm / < 0.1 ppm | ICP-Mass Spectrometry |
| Microbial Bioburden | Total Plate ≤ 1000 CFU/g | < 50 CFU/g | USP <61> / FDA-BAM |
Bioprocessing & Isolation Tech
Submerged Liquid Fermentation
To extract Erinacines, one must harvest the mycelium. Tihealth utilizes precise submerged liquid fermentation in medical-grade bioreactors. This cultivates pure, unadulterated mycelial networks, ensuring a 100% fungal matrix with zero starch (α-glucan) contamination from cheap oat or rice substrates.
Biphasic Full-Spectrum Extraction
Erinacines and Hericenones are highly lipophilic, rendering simple hot-water extractions completely ineffective. We execute a targeted dual-stage (water/ethanol) extraction. This isolates both the immunogenic complex sugars (β-glucans) and the fragile, neuro-active cyathane diterpenoids without thermal degradation.
Enzymatic Chitin Hydrolysis
To overcome the rigid chitin matrix of fungal cell walls, which impedes human digestion, we utilize a specialized bio-enzymatic degradation step prior to membrane dialysis. This releases bound nutrients, drastically improving the gastrointestinal absorption and bioavailability of the final API powder.
Mechanisms of Cellular Action
BBB Penetration & NGF Catalysis
Nerve Growth Factor (NGF) is a large protein naturally produced by the body, but it is too massive to cross the Blood-Brain Barrier (BBB). Erinacines (specifically Erinacine A from the mycelium) possess a distinctively low molecular weight, allowing them to freely permeate the BBB. Once inside the central nervous system, they directly catalyze the endogenous synthesis of NGF within cortical tissues and the hippocampus.
Physical Neuronal Repair & Remyelination
Driven by the surge in NGF, the extract stimulates profound physical changes in brain cytoarchitecture. It promotes the outgrowth of neurites (axons and dendrites) and critically accelerates the remyelination of damaged nerve sheaths. This physical repair mechanism provides formidable clinical support against cognitive decline, memory degradation, and neurodegenerative pathologies.
Gastrointestinal Epithelial Restoration
The dense β-glucan fractions (derived from the fruiting body) exert a potent protective barrier over compromised mucosal linings in the gut. They actively accelerate the mitosis of gastric epithelial cells and inhibit localized pro-inflammatory cytokine expression, structurally reinforcing the critical Gut-Brain Axis.
Microglial Cell Regulation (Neuroinflammation)
Beyond NGF stimulation, the bioactive profile actively dampens neuro-inflammation by suppressing the overactivation of microglial cells. By neutralizing intracellular oxidative stress, it mitigates the inflammatory cascades that accelerate neuronal apoptosis (cell death).
Targeted Industrial Sectors
Cognitive Enhancers & Nootropics
The pinnacle botanical API for formulating "Smart Drugs," focus-enhancing capsules, memory-retention tablets, and neuroprotective brain-health complexes.
Neurological Longevity Therapeutics
Heavily prescribed in clinical R&D and specialized medical foods targeting geriatric cognitive decline and the repair of central nervous system cytoarchitecture.
Adaptogenic Functional Beverages
Due to its strict molecular sieving process, it disperses flawlessly in liquid matrices, making it the premier choice for premium RTD "Mushroom Coffees" and stress-relief elixirs.
Gastrointestinal Barrier Support
Integrated into gut-health probiotics and mucosal repair powders, leveraging the high-density β-glucan fractions to support the microbiome and intestinal integrity.
B2B Formulation Services & Custom Synthesis
♦ Bespoke Active Matrix
We empower formulators to dictate specific standardization ratios. Whether you need a high-polysaccharide fraction for immunity or a Hericenone/Erinacine-heavy profile for nootropics, our extraction parameters are fully adjustable.
♦ Independent Third-Party Validation
Quality is not just claimed; it is mathematically verified. Every production lot undergoes strict analysis via LC-MS and Megazyme protocols. We issue comprehensive COAs confirming the total absence of agricultural grain fillers and heavy metals.
♦ Secure Commercial Fulfillment
Protecting your formulation IP is paramount. We operate under stringent confidentiality agreements, providing seamless bulk manufacturing, custom private-label sterile packaging, and comprehensive export documentation for rapid customs clearance.
Packaging, Logistics & Secure Payment
Reliable B2B Supply Chain Solutions
We provide pharmaceutical-grade aseptic packaging, efficient global logistics (Air/Sea freight with dual customs clearance), and secure multi-currency payment methods to ensure seamless, moisture-free cross-border transit for our B2B procurement partners.
Procurement & Formulation FAQ
01. What is the difference between Hericenones and Erinacines?
While both are highly potent neuro-stimulating compounds, Hericenones are synthesized primarily in the mature fruiting bodies, whereas Erinacines are uniquely found in the vegetative fungal mycelium. Our specialized Biphasic Extraction Process captures both, yielding a full-spectrum API capable of crossing the BBB for maximum efficacy.
02. How do you prove there is no cheap grain starch filler in the powder?
Conventional "mycelium-on-grain" biomass yields powders composed of up to 70% useless oats or rice starch. Because we cultivate our mycelium in submerged liquid bioreactors, our starch levels are naturally near zero. We prove this on your COA by specifically testing for β-glucans (the active fungal compound) alongside strict enzymatic Iodine tests that confirm α-glucans (starches) remain strictly ≤ 5.0%.
03. Can the active compounds actually penetrate the Blood-Brain Barrier (BBB)?
Yes. The Erinacines extracted via our targeted biphasic process possess an exceptionally low molecular weight and lipophilic structure, allowing them to freely permeate the BBB. Once inside, they directly stimulate the endogenous synthesis of Nerve Growth Factor (NGF) within cortical tissues and the hippocampus.
04. Does the powder maintain stability in functional coffees and beverages?
Absolutely. The macromolecular structure of our β-glucans, combined with our advanced membrane ultrafiltration, ensures excellent hydrophilic compatibility. When dispersed in hot or cold liquids, it dissolves rapidly without coagulation or the gritty sedimentation typical of crude mushroom powders.
05. What are your commercial supply constraints and packing parameters?
Our industrial baseline requirement is 25 kilograms per dispatch, securely packaged in rigid commercial drums lined with sterile double-bags. We maintain a robust inventory for immediate global dispatch, while bespoke extractions (e.g., custom Erinacine ratios) require standard production lead times of 7-10 days.
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