Iohexol Powder Cas No.66108-95-0
Product Source: Synthetic
Product Specification: ≥98%
CAS No.: 66108-95-0
Molecular Formula: C₁₉H₂₆I₃N₃O₉
Molecular Weight: 821.14 g/mol
Testing Method: HPLC
Active Ingredient: Iohexol
Product Characteristics: White or off-white powder or crystalline powder
Product Packaging: 1kg/bag; 25kg/drum
Storage Conditions: Moisture-proof, light-protected, sealed storage
Shelf Life: 24 months
Declaration of Use: This product is intended for industrial use or scientific research only.
High-Purity Iohexol API Powder
Low-Osmolar Contrast Medium (LOCM) | Pharmaceutical Grade for Diagnostic Radiology
1. Product Characterization & Value Proposition
Iohexol (CAS No. 66108-95-0) is a globally recognized non-ionic, water-soluble, low-osmolar contrast medium (LOCM). As a pivotal Active Pharmaceutical Ingredient (API) for diagnostic radiology, it provides a superior safety profile with significantly lower neurotoxicity and systemic adverse events compared to legacy ionic precursors.
Manufactured under stringent cGMP-compliant protocols, Xi'an Tihealth supplies pharmaceutical-grade Iohexol powder with an HPLC-validated purity of ≥98.5%. Our product is optimized for high-concentration injectables, ensuring excellent batch-to-batch consistency and ultra-low levels of free inorganic iodide. It remains the preferred choice for the industrial formulation of intravascular contrast agents used in CT scans, angiography, and diagnostic urography.
2. Technical Data Sheet (TDS) & Quality Standards
Our Iohexol API undergoes rigorous analytical verification to ensure its suitability for high-acuity sterile injectable formulations:
| Testing Item | Specification (USP / EP / ChP) |
|---|---|
| Chemical Name | 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide |
| Assay (HPLC, Anhydrous) | 98.5% - 101.0% |
| Iodine Content | 46.0% - 46.8% |
| Free Inorganic Iodide | ≤ 10 ppm (Critical for injection safety) |
| Bacterial Endotoxins | ≤ 0.5 EU/mg (Compliant with Injection Grade) |
3. Pharmacological Mechanism & Imaging Efficacy
Iohexol facilitates precision diagnostic imaging by selectively altering the X-ray attenuation coefficient in targeted vascular and tissue beds:
Radiopaque Visualization
The organically bound iodine atoms in Iohexol absorb X-rays in direct proportion to local concentration, enabling high-contrast visualization of arteries, veins, and internal organ structures during CT and fluoroscopy.
Non-Ionic LOCM Advantage
As a non-ionic monomer, Iohexol exhibits significantly lower osmolality than ionic contrast agents. This leads to improved patient tolerability, reduced osmotic stress on renal tubules, and a lower incidence of severe adverse reactions.
Glomerular Filtration Kinetics
Iohexol is minimally protein-bound and undergoes virtually no metabolic transformation. It is excreted almost entirely unchanged via the kidneys, providing excellent visualization of the urinary system during urography.
4. Core Pharmaceutical Applications
- Angiography & CT Enhancement: The primary API for manufacturing sterile intravenous solutions used in cardiovascular and cerebral imaging.
- Myelography & Intrathecal Use: Specifically refined for subarachnoid administration due to its exceptionally low neurotoxicity profile.
- Diagnostic Urography: Exploiting its rapid renal clearance for imaging the kidneys, ureters, and bladder.
B2B REGULATORY & HANDLING PROTOCOLS
Regulatory Notice: Iohexol API is supplied strictly for B2B industrial formulation, GMP manufacturing, and laboratory R&D. It is not a finished drug product and is strictly not for direct human injection. Downstream manufacturers must ensure sterile processing and strictly monitor renal function implications in final dosage forms.
5. Frequently Asked Questions (FAQ)
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