High-Purity Iopamidol API Powder | CAS 60166-93-0

Iopamidol (CAS No. 60166-93-0) is a premier non-ionic, low-osmolar contrast medium (LOCM) utilized extensively in high-precision diagnostic radiology. As a sophisticated Active Pharmaceutical Ingredient (API), it features a tri-iodinated benzene ring with strategically engineered hydrophilic side chains, ensuring exceptional water solubility and minimal systemic chemotoxicity. Manufactured at Xi'an Tihealth under rigorous cGMP protocols, our Iopamidol API exhibits a validated HPLC purity of ≥98.5%. By exercising absolute control over chiral purity and residual aromatic amines, we provide a reliable raw material that ensures the diagnostic clarity and patient safety required for advanced cardiovascular and neurological imaging.

To support seamless regulatory filing and ensure terminal formulation stability, our Iopamidol API meets the highest USP/EP pharmacopoeial standards:

• Tri-iodinated Attenuation: The high iodine payload (approx. 49%) per molecule ensures maximum X-ray absorption, providing sharp diagnostic contrast in vascular and soft tissue beds.
• Non-Ionic Biocompatibility: As a non-dissociating monomer, Iopamidol maintains lower osmolality than ionic alternatives. This reduces osmotic trauma to the vascular endothelium and minimizes the incidence of injection-site pain.
• Exceptional Neurotolerance: The presence of hydrophilic amide side chains reduces interaction with cell membranes, making Iopamidol one of the safest APIs for myelography and procedures involving the central nervous system.

Our Iopamidol API is manufactured with high crystalline stability and strictly controlled pH buffering capacity. This ensures that the final injectable solution remains stable and free from iodine cleavage during standard autoclaving cycles (121°C), preserving both clarity and potency.

Is this API suitable for high-concentration (370 mgI/mL) formulations?

Yes. Our API features excellent water solubility and low residual solvent levels, allowing formulators to achieve high iodine concentrations (up to 370 mgI/mL) while maintaining the low-viscosity profiles required for rapid automated injection during angiography.