Gadobutrol Powder Cas No.138071-82-6
Product Source: Synthetic
Product Specification: ≥95%
CAS No.: 138071-82-6
Molecular Formula: C₁₈H₃₁GdN₄O₉
Molecular Weight: 604.71 g/mol
Testing Method: HPLC
Active Ingredient: Gadobutrol
Product Characteristics: Typically white to off-white powder or solid
Product Packaging: 1kg/bag; 25kg/drum
Storage Conditions: Must be refrigerated to maintain product stability and prevent degradation.
Shelf Life: 24 months
Declaration of Use: This product is intended for industrial use or scientific research only.
Products Description
Gadobutrol API Powder | CAS 138071-82-6
Gadobutrol (CAS No. 138071-82-6) is a non-ionic, macrocyclic gadolinium-based contrast agent (GBCA) engineered for high-resolution magnetic resonance imaging (MRI). As a high-performance Active Pharmaceutical Ingredient (API), it is distinguished by its neutral molecular charge and exceptional kinetic stability. Manufactured via precision-controlled synthesis at Xi'an Tihealth, our Gadobutrol powder maintains an HPLC-validated purity of ≥99.0% (with higher pharmaceutical grades available upon request). Its robust macrocyclic structure ensures the secure sequestration of the Gadolinium ion (Gd3+), minimizing the risk of metal dissociation and tissue deposition. It is the definitive choice for formulators of high-concentration (1.0 M) diagnostic injectables targeting CNS and vascular pathologies.
Technical Data Sheet (TDS) & Specifications
| Parameter | Product Specification |
|---|---|
| Chemical Name | Gadolinium(III) 2,2',2''-(10-((2R,3S)-1,3,4-trihydroxybutan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate |
| CAS Number | 138071-82-6 |
| Molecular Formula | C₁₈H₃₁GdN₄O₉ |
| Molecular Weight | 602.71 g/mol |
| Assay (HPLC) | ≥ 99.0% |
| Storage Conditions | Refrigerated (2-8°C) to ensure stability |
| Shelf Life | 24 Months |
Pharmacological Mechanism & Kinetic Stability
- Macrocyclic Chelation: Gadobutrol utilizes a DOTA-like macrocyclic cage to encapsulate the Gadolinium ion. This configuration provides the highest level of thermodynamic stability, ensuring Gd3+ remains sequestered under physiological conditions.
- Relaxivity Performance: By altering the relaxation times of water protons, Gadobutrol enhances T1-weighted contrast. Its unique structure allows for a clinical concentration of 1.0 mol/L, providing superior diagnostic brightness with lower total gadolinium dose per patient.
- Hydrophilic Distribution: The non-ionic, highly hydrophilic molecule does not cross the intact blood-brain barrier and is excreted unchanged via glomerular filtration, ensuring rapid clearance and excellent tolerability.
Industrial Applications & Compliance
This high-specification Gadobutrol powder is intended exclusively for the following fields:
- Pharmaceutical R&D: Development of generic MRI contrast formulations and novel diagnostic protocols.
- CNS Imaging Research: Investigating blood-brain barrier integrity and neurovascular pathologies.
- Analytical Methodology: Serving as a high-quality reference standard for GBCA quantification.
Compliance Notice: For research and development use only. Not for human or veterinary diagnostic or therapeutic use. Direct administration is prohibited. Storage in refrigerated conditions is mandatory to prevent polymorphic degradation.
Frequently Asked Questions (FAQ)
Gadobutrol API in its powder form is sensitive to temperature-induced crystalline changes. Refrigeration (2-8°C) preserves chemical stability and ensures that the HPLC purity and solubility remain within specification throughout its 24-month shelf life.
Is this Gadobutrol API suitable for 1.0 M injectable formulations?
Yes. Our Gadobutrol powder is specifically synthesized for high-concentration formulation development. Its excellent water solubility and low residual solvent profile facilitate the production of high-relaxivity contrast agents with superior safety profiles.
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