Epalrestat Powder Cas No.82159-09-9

Xi'an Tihealth High Purity Epalrestat

Xi'an Tihealth provides pharmaceutical grade high-purity Epastatin raw materials. The main component content of the product is stable at ≥ 98% (detected by HPLC) and meets the standard characteristics. As a key aldose reductase inhibitor, this product is dedicated to the research, development and production of drugs for the treatment of diabetes neuropathy. We provide flexible packaging (from research and development samples to production batches), and store and transport under strict temperature control (recommended -20 ℃) and dark and dry conditions to ensure product stability and provide reliable guarantee for your pharmaceutical projects.

Ipastatin inhibits the activity of aldose reductase (AR), blocks the abnormal activation of the sorbitol pathway induced by hyperglycemia, reduces the accumulation of sorbitol and fructose in nerve tissue, and thus alleviates nerve fiber degeneration and demyelination. Specifically manifested in:

Symptom relief, nerve repair, blood flow restoration

1. Multidimensional improvement of diabetes neuropathy

2. Renal protection and metabolic regulation

3. Anti inflammatory and immune regulation

Reduce glycation end products (AGEs) and antioxidant stress

Ipastatin can inhibit the expression of pro-inflammatory factors such as interleukin-1 β (IL-1 β) and tumor necrosis factor - α (TNF - α), alleviate neurointimal inflammation, regulate immune cell activity, and reduce the risk of neurological recurrence.

1. For treatment of complications of diabetes:

• Diabetes peripheral neuropathy (DPN): improve limb numbness, pain and paresthesia.

• Diabetes retinopathy: delay the decline of vision caused by microvascular damage.

2. Drug development: raw materials used for DPN treatment drugs (such as tablets, capsules).

1,Target inhibition:

Selectively binds to the active site of aldose reductase, inhibiting its ability to catalyze the conversion of glucose to sorbitol.

2,Pathological correction:

Reduces intracellular sorbitol concentration, restores osmotic pressure balance, alleviates edema and oxidative stress damage in nerve cells, and repairs nerve conduction function.