Setmelanotide Powder Cas No.920014-72-8
Product Source: Synthetic
Assay Specification: ≥98%
CAS Number: 920014-72-8
Testing Method: HPLC
Active Ingredient: Setmelanotide
Chemical Formula: C₁₅₈H₂₅₄N₄₆O₄₅S₇
Molecular Weight: 3647.02 g/mol
Product Appearance: White to off-white lyophilized powder.
Product Application: Pharmaceutical and research use
Storage Conditions: Refrigerate at 2°C–8°C, protect from light and moisture
Shelf Life: 24 months
Setmelanotide API Powder (GLP-1/MC4R Research)
CAS: 920014-72-8 | SELECTIVE MC4R AGONIST | PHARMACEUTICAL-GRADE API
First-in-Class MC4R Agonist API
Setmelanotide (CAS No. 920014-72-8) is a synthetic, cyclic 8-amino acid peptide that acts as a highly selective melanocortin 4 receptor (MC4R) agonist. By bypassing upstream defects in the leptin-melanocortin pathway, it restores critical satiety signaling in patients with severe obesity caused by genetic mutations.
Manufactured under strict GMP protocols at Xi'an Tihealth, our Setmelanotide API achieves a validated HPLC purity of ≥98.0%. We utilize high-precision Solid-Phase Peptide Synthesis (SPPS) to minimize truncated sequences, ensuring absolute sequence fidelity for your clinical formulations.
Request Full COA & Synthesis DossierTechnical Specs
- ✓ Purity: ≥ 98.0% (HPLC)
- ✓ Sequence: Synthetic Cyclic Peptide
- ✓ Formula: C158H254N46O45S7
- ✓ Compliance: cGMP Manufacturing
- ✓ Storage: -20°C (Nitrogen-flushed)
Targeted Metabolic Regulation (MC4R)
Setmelanotide addresses energy balance through precise hypothalamic neuro-modulation:
- Restoring Satiety Signaling: By directly activating the MC4R pathway in the paraventricular nucleus, it re-establishes metabolic control in patients with POMC, PCSK1, or LEPR mutations.
- Hyperphagia Modulation: Clinical efficacy is demonstrated through significant reduction of pathological hunger and caloric intake.
- Energy Expenditure: Increases resting metabolic rate, providing a dual-approach (satiety + expenditure) to sustainable weight management.
Stability & Handling Integrity
Setmelanotide is highly sensitive to moisture and thermal fluctuations. Continuous storage at -20°C is mandatory to preserve the peptide chain integrity and 24-month potency. Use nitrogen-flushed, airtight containers during weighing to prevent hydrolysis.
Regulatory & Procurement FAQ
GLP-1 agents manage insulin and gastric emptying, whereas Setmelanotide is a precision pathway modifier that targets the MC4R in the hypothalamus, fixing the specific genetic satiety defect rather than just modulating blood sugar.
Q: What analytical methods ensure sequence integrity?We use high-resolution HPLC and LC-MS to verify molecular weight and amino acid sequence. Our synthesis process explicitly excludes deleterious impurities to ensure that every mg of API is usable for high-yield formulation.
Partner with a Reliable API Manufacturer.
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