To ensure the extreme safety required for systemic intravenous administration, our Iodixanol undergoes exhaustive analytical profiling for impurity and osmolality control:

Iodixanol facilitates high-resolution diagnostic imaging through its optimized molecular architecture:

• X-ray Attenuation: By carrying six iodine atoms per molecule, it provides high radiopacity, effectively enhancing the contrast between blood vessels, organ parenchymas, and surrounding soft tissues during X-ray, CT, and fluoroscopic procedures.
• The Isotonic Advantage: Unlike monomeric agents that are hyperosmolar, the dimeric structure of Iodixanol achieves the target iodine concentration while remaining isotonic to plasma. This minimizes osmotic-induced damage to the renal tubular cells and reduces fluid shifts across the vascular endothelium.
• Non-Ionic Stability: The absence of dissociated ions reduces electrical interference with excitable tissues, significantly decreasing the incidence of arrhythmias and neurological adverse events during cerebral and cardiac angiography.

• Clinical Contrast Agents: The definitive API for formulating Visipaque™ type injectables used in coronary angiography, peripheral arteriography, and contrast-enhanced CT.
• Density Gradient Centrifugation: Widely utilized in molecular biology for the purification of viruses (Adenovirus, AAV), the separation of fragile cells, and the isolation of exosomes due to its low toxicity and adjustable density.
• Urographic Imaging: Ideal for intravenous urography in patients with pre-existing renal impairment where low-osmolar agents are mandatory.

Iodixanol is an isotonic dimer, meaning its osmolality matches that of human blood. In contrast, Iohexol is a monomeric, low-osmolar agent that is still hypertonic compared to plasma. Iodixanol's isotonicity significantly reduces osmotic stress on the renal tubules, leading to a lower incidence of Contrast-Induced Acute Kidney Injury (CI-AKI).

What is the shelf life and storage protocol for Iodixanol powder?

Our Iodixanol API has a standard shelf life of 36 months when stored in original, unopened pharmaceutical-grade containers. It should be kept at room temperature (15-30°C), protected from direct light and moisture to prevent secondary degradation of the iodine-carbon bonds.

Can this API be used as a density gradient medium for viral purification?

Yes. Our high-purity Iodixanol is ideal for biological separation. Its non-ionic nature and low toxicity preserve the biological activity of viruses (like AAV) and delicate cell types better than sucrose or cesium chloride gradients.