Teduglutide Powder Cas No.197922-42-2
Product source: It is a glucagon like peptide-2 (GLP-2) analog
Content specification: ≥ 98%
CAS NO：197922-42-2
The chemical formula is C164H252N44O55S
Molecular weight: 3752.08
Detection method: HPLC
Active ingredient: Teduglutide
Product Description: White to off white freeze-dried powder
Product use: scientific research and pharmacological experiments, as well as short bowel syndrome
Product packaging: 1 gram/bottle; 10 bottles/box (customizable)
Product storage: It is recommended to store frozen at -15 ℃ to -20 ℃ and avoid direct sunlight
Shelf life: 24 months
Teduglutide API Powder | CAS 197922-42-2 | GLP-2 Receptor Agonist
Teduglutide (CAS No. 197922-42-2) is a recombinant 33-amino acid peptide and a potent analog of naturally occurring glucagon-like peptide-2 (GLP-2). Specifically engineered for the treatment of Short Bowel Syndrome (SBS), it features a critical single amino acid substitution (alanine to glycine at position 2) that grants resistance to degradation by dipeptidyl peptidase-4 (DPP-4), significantly extending its half-life. Manufactured under rigorous cGMP protocols at Xi'an Tihealth, our synthetic Teduglutide freeze-dried powder achieves a validated HPLC purity of ≥98.0%, with endotoxin levels strictly controlled within ≤5 EU/mg. This high-specification API (C164H252N44O55S, MW: 3752.08 g/mol) is optimized for pharmaceutical R&D and clinical formulation production, ensuring exceptional batch-to-batch consistency and high biological activity.
How does Teduglutide facilitate intestinal mucosal growth and absorption?
Teduglutide exerts its restorative effects by binding to GLP-2 receptors located on enteroendocrine cells and enteric neurons:
- Mucosal Hypertrophy Induction: By stimulating the release of growth factors (such as IGF-1 and KGF), Teduglutide promotes the proliferation of crypt cells and increases the height of intestinal villi, thereby expanding the effective surface area for nutrient absorption.
- Barrier Function Enhancement: It strengthens the intestinal epithelial barrier and improves tight junction integrity, reducing pathological permeability common in short bowel syndrome.
- Gastrointestinal Transit Regulation: Teduglutide inhibits gastric acid secretion and slows gastric emptying, optimizing the time available for the residual intestine to absorb fluids and essential nutrients.
What are the primary applications in SBS therapeutics and R&D?
- Short Bowel Syndrome (SBS) Management: The essential API for manufacturing therapeutic injections indicated for adult and pediatric patients dependent on parenteral nutrition.
- Parenteral Nutrition (PN) Volume Reduction: Clinically utilized to help patients achieve complete or partial weaning from external nutritional support by improving endogenous absorption.
- Pharmacological Research: A critical tool compound for investigating GLP-2 receptor kinetics, intestinal cell signaling, and novel drug delivery systems for peptides.
Compliance & Stability Notice: Teduglutide is a sensitive peptide API. Storage must be maintained at -15°C to -20°C in a light-protected environment. To prevent hydrolytic degradation, avoid multiple freeze-thaw cycles and ensure the freeze-dried powder remains under vacuum or inert gas seal.
Frequently Asked Questions (FAQ)
Natural GLP-2 has a very short half-life (approx. 7 minutes) due to rapid degradation by the DPP-4 enzyme. Teduglutide contains a specific substitution of glycine for alanine at position 2, which blocks DPP-4 cleavage, extending its in vivo half-life to approximately 2 hours, making it therapeutically viable.
What are the endotoxin and moisture control limits for this API?
At Xi'an Tihealth, we strictly monitor critical quality attributes (CQAs). Our Teduglutide API is validated with residual moisture ≤ 1.0% and bacterial endotoxins ≤ 5 EU/mg, meeting the stringent requirements for parenteral formulation development.
How do you ensure batch consistency for large-scale peptide synthesis?
We utilize standardized solid-phase peptide synthesis (SPPS) and advanced purification systems. Every batch is profiled via HPLC for purity and MS for sequence verification, ensuring that the peptide backbone and amino acid composition remain identical across all commercial supplies.
Can Teduglutide be used for research into inflammatory bowel diseases (IBD)?
While primarily indicated for SBS, researchers utilize our high-purity Teduglutide API to explore its regenerative effects in preclinical models of Crohn's disease and ulcerative colitis, focusing on its ability to enhance mucosal healing and barrier restoration.
What documentation can Xi'an Tihealth provide for regulatory support?
We provide a comprehensive technical data package, including the Certificate of Analysis (COA), HPLC chromatograms, Mass Spectrometry (MS) data, and MSDS. Our team is committed to assisting our partners through GMP audits and regulatory filings globally.
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