CDP-Choline API Powder CAS 987-78-0
Product source: Synthetic
Content specification: ≥ 98%
CAS number: 987-78-0
Testing method: HPLC
Active ingredient: Citicoline
Product packaging: 1kg/bag; 25kg/drum
Product storage: Sealed, cool, dry and dark place
Shelf life: 24 months
CDP-Choline API Powder| CAS 987-78-0 | Microencapsulated Mitochondrial Energy Pump
Citicoline (Cytidine 5'-diphosphocholine, CAS No. 987-78-0) is a critical intermediate in the Kennedy pathway, functioning as the rate-limiting biological precursor for phosphatidylcholine synthesis. At Xi'an Tihealth, we provide a specialized Microencapsulated Grade powder specifically designed to resolve industrial adhesion issues. By utilizing a lipid-based micro-coating, we achieve high-efficiency moisture protection and superior flowability, preventing capsule machine sticking and dosage variability. Our CDP-Choline is characterized by ultra-low solvent residuals and exceptional water solubility, making it the premier choice for pharmacological research into neuro-regeneration, mitochondrial energetic support, and cognitive membrane repair.
⚠️ REGULATORY COMPLIANCE & MANUFACTURING NOTICE
Research & Industrial Use Only: This Citicoline is supplied as a raw material API powder intended exclusively for professional laboratory research and industrial pharmaceutical manufacturing. It is NOT a finished consumer product.
Machinability Assurance: Our microencapsulated technology is engineered to solve the "sticking" challenges on high-speed capsule filling machines. Xi'an Tihealth Biotechnology Co., Ltd. assumes no liability for unauthorized usage or non-compliant handling. Storage must be maintained in a dry, dark environment to preserve the integrity of the micro-coating.
Pharmacological Mechanism and Mitochondrial Bioenergetics
CDP-Choline facilitates cellular repair and energy efficiency through its dual-moiety structure:
- Membrane Phospholipid Synthesis: As a direct donor of cytidine and choline, it drives the Kennedy Pathway, increasing the rate of phosphatidylcholine (PC) synthesis within the neuronal membranes. This is critical for repairing membranes damaged by oxidative stress or ischemia.
- Mitochondrial Energy Pump: Citicoline has been shown to enhance the activity of mitochondrial ATPase and stabilize the mitochondrial membrane potential, effectively acting as an energetic pump to maintain cerebral ATP levels.
- Synergistic Neurotransmission: Beyond membrane repair, CDP-Choline modulates the release of norepinephrine and dopamine, supporting cognitive focus and neuro-transmitter homeostasis in R&D neuro-recovery models.
Technical Specifications and Solvent Residual Audit
| Specification | Microencapsulated CDP-Choline Powder |
| Assay (HPLC, Anhydrous) | ≥ 98.0% (Active Molecule) |
| Residual Solvents (ICH Q3C) | Ethanol/Methanol < 500ppm (Ultra-low residue) |
| Water Solubility | Excellent (Instant dispersion upon release) |
| Particle Flowability | Optimized for high-speed capsule filling (Anti-adhesion) |
Bench Note: Standard Citicoline is susceptible to moisture-induced clumping. Our anti-hygroscopic grade utilize a precise particle coating to block surface hydroxyl interactions. This ensures that the powder does not "bridge" in the hopper or stick to the dosing discs of the encapsulation machine.
Global Research Procurement FAQ
While Alpha-GPC is a more concentrated choline donor, Citicoline is a more comprehensive "neuromembrane repair" molecule. CDP-Choline provides Cytidine, which is the precursor for Uridine and essential for the synthesis of phospholipids. In R&D models for stroke or neuro-decline, Citicoline is often prioritized for its mitochondrial stabilizing properties.
How do you achieve ultra-low solvent residuals in your synthetic process?Many commercial Citicoline products have residual odor due to secondary synthesis solvents. Xi'an Tihealth employs a multi-stage vacuum crystallization and advanced spray-drying process to ensure solvent levels are far below ICH Q3C limits. This results in a high-purity, odorless API suitable for high-end nutriceutical formulations.
Does the microencapsulation affect the final bio-availability or solubility?No. Our micro-coating is designed for **triggered release** in the gastrointestinal tract. In formulation research, the powder exhibits superior dry-flow characteristics, but once introduced to the aqueous environment of the digestive system, it rapidly dissociates to provide full bio-availability of the Citicoline molecule.
Xi'an Tihealth Biotechnology Compliance Statement: Raw material API for industrial R&D only. User assumes all risks for unauthorized clinical applications.
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