Phosphatidylserine CAS 51446-62-9
Product source: Synthetic
Content specification: ≥ 99%
CAS number: 51446-62-9
Testing method: HPLC
Active ingredient: Phosphatidylserine
Product packaging: 1kg/bag; 25kg/drum
Product storage: Sealed, cool, dry and dark place
Shelf life: 24 months
Phosphatidylserine (PS) | CAS 51446-62-9 | FDA-Qualified Cognitive Nutrient
Phosphatidylserine (PS, CAS No. 51446-62-9) is a vital acidic phospholipid and a structural component of the neuronal cell membrane. It is the only nutrient to receive a Qualified Health Claim from the US FDA for reducing the risk of cognitive dysfunction. At Xi'an Tihealth, we specialize in high-specification Sunflower-Derived PS (Soy-Free). This premium raw material eliminates the risk of soybean allergens (IP control) and provides a clean, Non-GMO profile for high-end nutriceutical formulations. Synthesized via enzymatic conversion (Phospholipase D), our PS achieves a validated HPLC purity and ensures the maintenance of membrane fluidity and cell-to-cell communication in advanced pharmacological research and neuro-regeneration models.
⚠️ REGULATORY COMPLIANCE & ALLERGEN NOTICE
Professional Use Only: This Phosphatidylserine is supplied exclusively as a raw material API powder for professional laboratory research and industrial pharmaceutical manufacturing. It is NOT a finished consumer product.
Soy-Free Assurance: Our Sunflower-derived PS is specifically engineered for markets with strict allergen labeling requirements. It is 100% free from soybean proteins. Xi'an Tihealth Biotechnology Co., Ltd. assumes no liability for unauthorized direct usage or non-compliant formulation in retail sectors.
Biochemical Mechanism and Neuronal Membrane Fluidity
PS facilitates cerebral health through the targeted modulation of the cellular lipid bilayer:
- Membrane Integrity & Signaling: Phosphatidylserine is localized to the internal layer of the cell membrane. It activates key enzymes such as Protein Kinase C (PKC) and Na+/K+-ATPase, which are fundamental for synaptic plasticity and neurotransmitter release (ACh, Dopamine).
- Glucose Metabolism Support: Research indicates that PS enhances glucose metabolism in the brain, effectively providing the energetic throughput required for cognitive focus and memory retention under metabolic stress.
- Cortisol Regulation: Beyond cognitive support, PS acts as a physiological buffer to attenuate the secretion of cortisol during physical and psychological stress, making it a valuable API for research into endurance and HPA-axis homeostasis.
Technical Specifications and Source Audit
| Source Material | Sunflower Seed (Helianthus annuus) |
| Allergen Status | Soy-Free / IP Control / Non-GMO |
| Assay (HPLC, on Dry Basis) | ≥ 20.0%, 50.0%, 70.0% , 99.0%; (Customizable) |
| Residual Solvents (ICH Q3C) | Ethanol/Acetone < 5000ppm (Compliant) |
| Physical State | Light yellow to brown fine powder (Neutral odor) |
Formulator Bench Note: Phosphatidylserine is highly sensitive to oxidative stress and moisture. We utilize multi-layer aluminum vacuum packaging. During formulation, avoid exposure to temperatures above 40°C and ensure the use of antioxidants (e.g., Vitamin E) to prevent lipid peroxidation of the unsaturated fatty acid chains.
Global Research Procurement FAQ
The primary driver is the allergen profile. Soy-derived PS requires "contains soy" labeling, which is a major barrier for the EU and US health markets. Additionally, sunflower sources are naturally Non-GMO, whereas soybean IP (Identity Preserved) control is more complex and prone to cross-contamination. Sunflower PS offers a cleaner, high-value consumer perception.
Does Xi'an Tihealth ensure the absence of residual Phospholipase D (PLD) in the final API?Yes. Our synthesis uses high-activity PLD for the conversion of PC to PS. Through a multi-stage precipitation and washing process, the enzyme is completely denatured and removed. Every batch is audited for protein residues to ensure it remains below detection limits for pharmaceutical-grade purity.
What defines the stability of your PS against lipid peroxidation?Because PS contains polyunsaturated fatty acids, it is susceptible to oxidation. We control the Peroxide Value (PV) strictly during manufacturing. We provide the material in nitrogen-flushed, light-blocked packaging. For liquid or capsule formulations, we provide specific stability protocols to maintain the active PS content throughout the 24-month shelf life.
Xi'an Tihealth Biotechnology Compliance Statement: Raw material API for industrial R&D only. User assumes all risks for unauthorized direct usage.
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