Phosphatidylserine CAS 51446-62-9
Product source: Synthetic
Content specification: ≥ 99%
CAS number: 51446-62-9
Testing method: HPLC
Active ingredient: Phosphatidylserine
Product packaging: 1kg/bag; 25kg/drum
Product storage: Sealed, cool, dry and dark place
Shelf life: 24 months
Phosphatidylserine (PS)
FDA-Qualified Cognitive Nutrient | Sunflower-Derived (Soy-Free)
⚠️ REGULATORY COMPLIANCE & ALLERGEN NOTICE: Supplied exclusively as a raw material API powder for professional laboratory research and industrial pharmaceutical/nutriceutical manufacturing. Our Sunflower-derived PS is 100% free from soybean proteins, meeting strict international allergen labeling requirements.
🌻 100% Sunflower-Derived
Naturally Non-GMO IP control source that completely eliminates soybean allergen labeling barriers for EU and US consumer markets.
🔬 Enzymatic Conversion
Synthesized via high-activity Phospholipase D (PLD) with thorough enzyme denaturation and multi-stage purification to ensure ultra-low residual protein.
📑 FDA Qualified Claim
Backing the only vital acidic phospholipid recognized by the US FDA for reducing the risk of cognitive dysfunction and memory decline.
Product Characterization
Phosphatidylserine (PS, CAS No. 51446-62-9) is a vital acidic phospholipid and a structural component of the neuronal cell membrane. It is the only nutrient to receive a Qualified Health Claim from the US FDA for reducing the risk of cognitive dysfunction.
At Xi'an Tihealth Biotechnology Co., Ltd., we specialize in high-specification Sunflower-Derived PS (Soy-Free). This premium raw material eliminates the risk of soybean allergens (IP control) and provides a clean, Non-GMO profile for high-end nutriceutical formulations, ensuring the maintenance of membrane fluidity and cell-to-cell communication in advanced pharmacological research.
Technical Specifications and Source Audit
| Analytical Parameter | Xi'an Tihealth Specification |
|---|---|
| Source Material | Sunflower Seed (Helianthus annuus) |
| Allergen Status | Soy-Free / IP Control / Non-GMO |
| Assay (HPLC, on Dry Basis) | ≥ 20.0%, 50.0%, 70.0%, 99.0% (Customizable) |
| Residual Solvents (ICH Q3C) | Ethanol/Acetone < 5000ppm (Compliant) |
| Physical State | Light yellow to brown fine powder (Neutral odor) |
Formulator Bench Note: Phosphatidylserine is highly sensitive to oxidative stress and moisture. We utilize multi-layer aluminum vacuum packaging. During formulation, avoid exposure to temperatures above 40°C and ensure the use of antioxidants (e.g., Vitamin E) to prevent lipid peroxidation of the unsaturated fatty acid chains.
Biochemical Mechanism
- Membrane Integrity & Signaling: Localized to the internal layer of the cell membrane, activating key enzymes like PKC and Na+/K+-ATPase fundamental for synaptic plasticity and neurotransmitter release.
- Glucose Metabolism Support: Enhances cerebral glucose metabolism, providing the energetic throughput required for cognitive focus and memory retention.
- Cortisol Regulation: Acts as a physiological buffer to attenuate cortisol secretion during physical and psychological stress, supporting endurance and HPA-axis homeostasis.
Applications & Advantages
- Advanced Nootropic Stacks: Premium active ingredient for executive cognitive enhancement and memory support formulations.
- Sports Nutrition Formulations: Valued in pre-workout and recovery stacks for stress resilience and reduced exercise-induced cortisol spikes.
- Allergen-Free Positioning: Solves compliance hurdles for global brands aiming at clean-label, soy-free dietary supplements.
Global Research Procurement FAQ
Why is Sunflower-derived PS preferred over Soybean-derived PS for premium brands?
The primary driver is the allergen profile. Soy-derived PS requires "contains soy" labeling, which is a major barrier for the EU and US health markets. Additionally, sunflower sources are naturally Non-GMO, whereas soybean IP (Identity Preserved) control is more complex and prone to cross-contamination. Sunflower PS offers a cleaner, high-value consumer perception.
Does Xi'an Tihealth ensure the absence of residual Phospholipase D (PLD) in the final API?
Yes. Our synthesis uses high-activity PLD for the conversion of PC to PS. Through a multi-stage precipitation and washing process, the enzyme is completely denatured and removed. Every batch is audited for protein residues to ensure it remains below detection limits for pharmaceutical-grade purity.
What defines the stability of your PS against lipid peroxidation?
Because PS contains polyunsaturated fatty acids, it is susceptible to oxidation. We control the Peroxide Value (PV) strictly during manufacturing. We provide the material in nitrogen-flushed, light-blocked packaging. For liquid or capsule formulations, we provide specific stability protocols to maintain the active PS content throughout the 24-month shelf life.
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