Alpha-GPC API CAS 28319-77-9
Product source: Synthetic
Content specification: ≥99%
CAS number: 28319-77-9
Testing method: HPLC
Active ingredient: L-α-Glycerylphosphorylcholine (Alpha-GPC)
Product packaging: 1kg/bag; 25kg/drum
Product storage: Sealed, cool, dry and dark place, avoid moisture and high temperature
Shelf life: 24 months
Alpha-GPC API | CAS 28319-77-9 | ≥ 99% Choline Glycerophosphate
Alpha-GPC (L-α-Glycerylphosphorylcholine, CAS No. 28319-77-9) is a premier cholinergic compound that serves as a direct precursor for acetylcholine synthesis. At Xi'an Tihealth, we provide a high-specification API produced via optimized biocatalysis, ensuring a purity that consistently meets and exceeds CP2010 pharmacopoeial standards. Recognized for its unique ability to cross the blood-brain barrier (BBB), our Alpha-GPC is a white, high-purity crystalline powder optimized for pharmaceutical-grade nutriceuticals and cognitive research. Given its extreme hygroscopicity, we utilize specialized vacuum-sealed nitrogen packaging to maintain the precise physicochemical markers required for high-end formulation stability.
⚠️ REGULATORY COMPLIANCE & PHYSICAL HANDLING NOTICE
Professional Research Use Only (RUO): This ≥ 99% purity Alpha-GPC is a raw material API powder intended strictly for professional laboratory research and industrial pharmaceutical manufacturing. It is NOT a finished consumer product.
Handling Protocol: As confirmed in our COA, this material is highly hygroscopic. Exposure to ambient humidity will result in rapid deliquescence. Handling must occur in climate-controlled environments (< 30% RH). Xi'an Tihealth Biotechnology Co., Ltd. assumes no liability for material degradation due to unauthorized direct use or non-compliant storage.
Alpha-GPC Technical Data Sheet (TDS) & COA Specification
The following parameters represent the validated batch results for our Choline Glycerophosphate API, complying with CP2010 standards:
| Item | Specification | Batch Result |
|---|---|---|
| Appearance | White powder, neutral odor, highly hygroscopic | Complies |
| Identification | TLC: Same spot as standard solution (Rf) | Complies |
| Specific Optical Rotation | -2.4° ~ -2.8° | -2.744° |
| Heavy Metals (as Pb) | ≤ 10 ppm | Complies |
| Sulphates (SO4) | ≤ 0.02% | Complies |
| Chlorides (Cl) | ≤ 0.02% | Complies |
| pH Value | 4.5 ~ 7.0 | 5.92 |
| Water Content | ≤ 2.0% | 0.42% |
| Assay (on Dried Basis) | 98.0% ~ 102.0% | 100.55% |
Conclusion: The product complies with CP2010 standards.
Pharmacological Mechanism and Cholinergic Potentiation
Alpha-GPC provides high-density choline delivery for targeted neuro-cognitive support:
- Acetylcholine Synthesis: It directly increases free choline levels, the essential building block for acetylcholine, which modulates cognitive function, memory, and physical power output.
- BBB Permeability: Its lipid-soluble structure allows it to bypass the blood-brain barrier efficiently, ensuring higher cerebral bioavailability compared to standard choline salts.
- Membrane Support: As a phospholipid precursor, it supports the structural integrity of neuronal membranes and helps maintain glial cell health.
Global Research Procurement FAQ
As seen in our CP2010 COA, we strictly audit the specific optical rotation (-2.4° ~ -2.8°). This is critical for confirming the enantiomeric purity of the L-isomer. Our latest result of -2.744° demonstrates our synthesis process's consistency in maintaining high biological activity.
What measures prevent moisture absorption during international shipping?
Given the 0.42% water content in our COA, we utilize triple-layered pharmaceutical packaging: double inner PE bags with high-density nitrogen sealing, followed by a vacuumed aluminum foil bag with desiccant, and housed in a reinforced cardboard drum to ensure zero purity loss.
Can Xi'an Tihealth provide full technical dossiers for factory audits?
Yes. We provide a complete technical package including the COA, 1H-NMR data, Method of Analysis (MOA), and Batch Manufacturing Records (BMR). Our team supports compliance with global quality systems (ISO 9001:2015) and regulatory audits.
Xi'an Tihealth Biotechnology Compliance Statement: Raw material API intended for industrial pharmaceutical manufacturing and professional laboratory research only.
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