Urolithin A
Product source: Pomegranate, nuts and other fruits containing tannic acid
Content specification: Standard purity: ≥ 98% (HPLC, suitable for scientific research and pharmaceutical grade)
Industrial grade: ≥ 95% (applicable to health product raw materials)
Customized specifications: 50% -90% (adjusted according to customer needs)
CAS NO：1143-70-0
Detection method: HPLC
Product mesh: 80-100 mesh (can be customized with ultra-fine powder of 200 mesh or more)
Product Description: White to light yellow crystalline powder
Product usage: in the fields of medicine, health products, cosmetics, etc
Product packaging: 100g, 1KG/aluminum foil bag, 25kg/cardboard drum.
Product storage: This product should be sealed, shaded, and kept away from high temperatures. It should be stored in a dry, cool, and well ventilated place
Shelf life: 24 months
Urolithin A API Powder | CAS 1143-70-0 | Mitophagy Activator
Xi'an Tihealth Biotechnology Co., Ltd. is a premier global B2B manufacturer of ultra-high purity Urolithin A (UA). Bypassing the limitations of human gut microbiome conversion, our Urolithin A is synthesized via an advanced, proprietary microbial fermentation process utilizing natural ellagitannins extracted from pomegranates, ensuring a highly stable and bio-identical end product.
Rigorously standardized to ≥ 98.0% Purity (HPLC), our Urolithin A is the ultimate cellular anti-aging and sports nutrition API. It is scientifically proven to activate mitophagy-the targeted clearing and recycling of dysfunctional mitochondria-thereby restoring cellular energy (ATP) production, enhancing skeletal muscle endurance, and delaying age-related decline.
Technical Data Sheet (TDS) & Specifications
| Analytical Parameter | Xi'an Tihealth Specification |
|---|---|
| Chemical Name | 3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one |
| CAS Number | 1143-70-0 |
| Purity (Assay) | ≥ 98.0% (HPLC - UV 254 nm) |
| Appearance | White to off-white crystalline powder |
| Impurities Control | Urolithin B ≤ 0.5% / Ellagic Acid ≤ 0.2% |
| Moisture Content | ≤ 3.0% (Karl Fischer) |
| Safety Compliance | Heavy Metals ≤ 0.5 ppm each; Total Plate Count ≤ 500 CFU/g |
Industrial Processing Metrics: Synthesized under strict GMP protocols. Excellent solubility in DMSO and lipid matrices. Packaged in 1kg to 25kg vacuum-sealed, light-resistant containers to ensure long-term stability.
Advanced Bio-Fermentation Production Process
- Clean Bio-Enzymatic Conversion: Utilizing specialized microbial strains and precise fermentation control, we achieve an industry-leading precursor conversion rate (>85%) from natural pomegranate extracts. This bypasses hazardous chemical synthesis, ensuring a safer, highly bio-identical API.
- Chromatographic Purification (≥98.5% Purity): Our pharmaceutical-grade downstream processing involves advanced column chromatography followed by precision crystallization. This completely separates related impurities, guaranteeing an ultra-high purity level that consistently tests above 98.5%.
- Scalable & Compliant Supply Chain: Operating within a dedicated GMP-certified production line, our output easily scales to meet commercial demands. We strictly monitor genotoxic impurities and solvent residues in accordance with ICH Q3C guidelines.
Mitophagy Mechanism & Formulation Applications
The clinical efficacy of our Urolithin A focuses on deep cellular rejuvenation and is heavily utilized in the following product categories:
- Targeted Mitophagy & Longevity Supplements: Acts as a direct activator of mitophagy to clear defective mitochondria. It is the foundational API for high-end anti-aging capsules, frequently formulated alongside NAD+ boosters (NMN/NR) and Resveratrol for synergistic cellular repair.
- Sports Nutrition & Muscle Endurance: By optimizing cellular ATP production, Urolithin A significantly improves muscle endurance and aerobic capacity. Highly effective in pre-workout and post-recovery formulations combatting age-related muscle decline (sarcopenia).
- Neuroprotection Formulations: Clears defective mitochondria in neurons, reducing neuroinflammation. Leveraged in cutting-edge nootropics to support memory retention.
- Premium Nutricosmetics: Used in functional "beauty from within" dietary products targeting dermal cellular health and protecting the skin against mitochondrial oxidative stress.
Formulator & Procurement FAQ
Because our starting materials are botanically derived (pomegranate extracts varying slightly across seasons), the final crystalline powder may range from pure white to a very pale off-white/yellowish tint. However, the HPLC purity (≥ 98.0%) and molecular structure remain strictly identical.
Urolithin A is a highly lipophilic molecule. While it has low solubility in water, it exhibits excellent solubility in DMSO (≥ 50 mg/mL) and lipid bases, making it ideal for softgel suspensions, liposomal delivery systems, and fat-soluble dietary capsules.
To support laboratory R&D and pilot formulation, we offer an MOQ as low as 10g. For industrial and commercial production runs, the standard bulk MOQ is 1kg. We offer highly competitive, tiered pricing and maintain robust safety stock for rapid global dispatch.
Xi'an Tihealth Biotechnology Co., Ltd. Quality Commitment: Highly purified metabolite intended strictly for laboratory research and dietary supplement manufacturing.
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