Flammulina Velutipes Extract
English name:Enoki Mushroom extract
Plant source: Flammulina velutipes, also known as Flammulina velutipes, Flammulina velutipes, Flammulina velutipes, Agaricus bisporus, Agaricus bisporus, Agaricus bisporus, Agaricus bisporus, etc.
Content specifications: 4: 1. 10:1, 20:1, 30:1,50:1
polysaccharide content 10% -40%
Testing method:HPLC
Active ingredient: Flammulina velutipes polysaccharide
Number of mesh: 80 mesh
Appearance: Light yellow to brownish yellow powder
Product Usage: Food and Beverage, Functional Food, Meal Replacement Powder, Solid Beverage, Pressed Candy, etc.
Product packaging: 1KG/aluminum foil bag;25KG/cardboard drum
Product storage: Store in a dry and cool place, away from sunlight and high temperatures
Shelf life: 24 months
Product Overview
Pharmaceutical-Grade Flammulina Velutipes Extract
Manufactured by Xi'an Tihealth Biotechnology Co., Ltd.
Xi'an Tihealth is a premier global B2B manufacturer of highly purified Flammulina Velutipes Extract (commonly known as Enoki Mushroom Extract). Sourced exclusively from controlled-environment cultivation to prevent heavy metal and soil contamination, our raw materials provide an impeccably clean fungal biomass foundation.
Utilizing our proprietary Ultrasound-Microwave Synergistic Extraction technology combined with enzymatic hydrolysis, we specifically isolate the mushroom's potent Active Polysaccharides and β-Glucans. Standardized to concentrations ranging from 10% to 50%, our light-brown fine powder offers exceptional water solubility (≥99%). Supported by advanced Zn-Polysaccharide chelation processes, it delivers superior immunomodulatory, hepatoprotective, and antioxidant properties, making it an ideal Active Pharmaceutical Ingredient (API) for functional foods, post-recovery clinical nutrition, and premium immune-support supplements.
Technical Data Sheet (TDS) & Analytical Control
| Analysis Item | Target Specification | Result (Typical Batch) | Methodology |
|---|---|---|---|
| Botanical Source | Fruiting Body of Flammulina velutipes | Verified | Macroscopic ID |
| Total Polysaccharides | ≥ 30.0% | 32.8% | Phenol-Sulfuric Acid / UV |
| β-Glucan Content | ≥ 15.0% | 16.5% | HPLC-ELSD |
| Solubility (Water) | ≥ 99% Soluble (No residue) | Complies | Aqueous Dispersion |
| Loss on Drying | ≤ 8.0% | 5.2% | Karl Fischer / USP |
| Ash Content | ≤ 5.0% | 3.5% | USP <281> |
| Heavy Metals (Pb, As) | ≤ 2.0 ppm / ≤ 1.0 ppm | < 1.0 ppm / < 0.5 ppm | ICP-MS |
| Total Plate Count | ≤ 1000 CFU/g | 120 CFU/g | ISO 4833-1 |
Manufacturing & Processing Excellence
Ultrasound-Microwave Synergy
Traditional water extraction yields poor active retention. Tihealth employs dynamic parameter optimization (200W ultrasound + 650W microwave) to increase the polysaccharide extraction rate up to 11.35%, while strictly preventing high-temperature carbonization and deactivation of the glucans.
Zn-Polysaccharide Chelation
Our proprietary process leverages zinc ion chelation during extraction. This structural modification has been scientifically shown to enhance the extract's antioxidant capacity (DPPH radical scavenging rate ↑15-30%) and amplify its overall bioactivity compared to standard mushroom extracts.
Precision Impurity Removal
Through advanced enzymatic hydrolysis and macroporous resin chromatography, we achieve a pigment/small-molecule removal rate of ≥95%. This guarantees an exceptionally pure, light-colored powder with ≥99% water solubility, perfectly suited for clear functional beverages.
Evidence-Based Physiological Benefits
Profound Immunomodulatory Efficacy
The high-molecular-weight β-glucans actively bind to Dectin-1 receptors on macrophages. This triggers the secretion of TNF-α and IL-6, balances the Th1/Th2 immune response, and significantly enhances Natural Killer (NK) cell activity for robust pathogen clearance.
Hepatoprotective (Liver Shield) Mechanisms
Exhibits strong dual-regulation capabilities in the liver. Clinical models demonstrate that the extract can decrease ALT/AST enzyme activity by over 30% during induced liver injury, while simultaneously aiding in lipid reduction and metabolic balance.
Prebiotic Gut Health Support
The active polysaccharides resist gastric digestion to act as potent prebiotics in the colon. They specifically promote the proliferation of beneficial flora (e.g., Bifidobacterium and Lactobacillus), reinforcing the intestinal barrier via ZO-1 tight junction proteins.
Systemic Antioxidant & Anti-Aging
Demonstrates a DPPH radical scavenging rate of ≥85% (at 10mg/mL). It activates the Nrf2 cellular pathway, upregulating endogenous antioxidants like SOD and GSH-Px, which mitigates oxidative stress and protects against collagen degradation.
Industrial Formulation Applications
Dietary Supplements
The foundational API for formulating premium immune-boosting capsules, liver-protection tablets, and targeted prebiotic fiber blends.
Functional Foods & Beverages
Due to its ≥99% solubility and acid resistance (stable at pH 2.0), it integrates seamlessly into clear RTD botanical drinks, energy gels, and fermented dairy.
Cosmeceuticals & Skincare
Utilized in advanced anti-aging serums and post-sun repair masks. Its skin-friendly pH (5.5-6.5) promotes collagen synthesis and reduces UV-induced matrix metalloproteinase (MMP-1) expression.
Veterinary & Aquaculture Feed
Highly heat-stable (>85% activity retention at 120°C pelletizing). Added to pet nutrition to improve GI health and to aquafeed to boost innate immunity against viral pathogens.
Contract Manufacturing & Global Supply Chain
♦ Precise Active Customization
We strictly tailor the concentration of Total Polysaccharides (from 10% to 50%) and isolated β-Glucans to meet your specific therapeutic claims and budgetary requirements.
♦ Traceable Quality Control
Every batch undergoes strict cGMP-certified analysis via HPLC/UV and DPPH validation. We guarantee Heavy Metals (Lead) ≤ 2.0 ppm, far stricter than general industry standards.
♦ Strict Brand Confidentiality
Secure IP protection via NDAs. We offer blind shipping, private label bulk packaging (1kg foil bags to 25kg drums), and full FDA/EU regulatory documentation support.
Packaging, Logistics & Secure Payment
Reliable B2B Supply Chain Solutions
We provide pharmaceutical-grade aseptic packaging, efficient global logistics (Air/Sea freight with dual customs clearance), and secure multi-currency payment methods to ensure seamless, oxidation-free cross-border transit for our B2B procurement partners.
Formulator & Procurement FAQ
01. Do you test for both Total Polysaccharides and specific β-Glucans?
Yes. While generic "polysaccharide" tests (like the Phenol-Sulfuric method) can detect inactive alpha-glucans (starches), we specifically utilize HPLC-ELSD to quantify the therapeutically active β-Glucan fraction (≥15%), ensuring absolute potency for immune formulations.
02. Is the powder completely water-soluble for clear beverage applications?
Absolutely. Through advanced macroporous resin chromatography and enzymatic hydrolysis, we remove heavy insoluble chitins. The resulting extract exhibits ≥99% water solubility with zero sedimentation, ideal for clear functional RTD drinks.
03. How does Flammulina extract compare to Reishi (Ganoderma) extract?
While Reishi is renowned for immunity, its polysaccharides typically have lower water solubility (30-50%). Flammulina extract offers ≥99% solubility, excellent prebiotic gut-health synergy, and represents a highly cost-effective alternative for formulating comprehensive immune complexes.
04. Does the extraction process leave harmful solvent residues?
No. We exclusively use a "Dual Extract" method involving only purified water and food-grade ethanol. Post-extraction vacuum evaporation ensures residual ethanol is strictly < 5000 ppm, conforming to global pharmaceutical safety standards.
05. What is the Minimum Order Quantity (MOQ) and lead time?
MOQ for commercial mass production is 25kg (standard double-lined cardboard drum). Standard extracts are dispatched within 7-10 days. Samples (10g-1kg) are available for your R&D formulation trials upon request.
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