Chaste Berry Extract
Raw material aliases: Western Vitex fruit, Holy tree fruit, Virtuous tree fruit, Huangyang Vitex fruit, etc.
Extraction source: Fruit of Chasteberry tree (agnus castus)
Appearance: Brown yellow powder
Detection method: UV
Specifications: 10:1,20:1, 30:1, 50:1 or customized according to customer needs.
Number of mesh: filtered through 80-100 mesh
Packaging method: 1KG/aluminum foil bag 25KG/cardboard drum (with double-layer moisture-proof plastic bag inside) or packaged according to customer needs
Storage method: Sealed and stored in a cool and dry place
Storage period: 24 months
Pharmaceutical-Grade Chaste Berry Extract (Vitex agnus-castus)
Manufactured by Xi'an Tihealth Biotechnology Co., Ltd.
Xi'an Tihealth is a premier global B2B supplier of highly purified Chaste Berry Extract (Vitex agnus-castus). Globally recognized as a cornerstone botanical for female endocrinology, we source the highest quality mature fruits to ensure a dense, highly active phytochemical profile, free from heavy metal and pesticide contamination.
Through our advanced hydro-ethanolic extraction and precision macroporous resin purification, we successfully isolate and concentrate the fruit's core bioactives: Iridoid glycosides (specifically Agnuside and Aucubin), Flavonoids, and specific Diterpenoids. Standardized to exacting specifications, this 100% hormone-free botanical powder acts on the hypothalamic-pituitary axis to naturally balance estrogen and progesterone levels. It serves as an indispensable Active Pharmaceutical Ingredient (API) for premium PMS-relief nutraceuticals, cycle-regulating capsules, and targeted hormonal-acne cosmetics.
Technical Data Sheet (TDS) & Analytical Control
| Analysis Item | Target Specification | Result (Typical Batch) | Methodology |
|---|---|---|---|
| Botanical Source | Dried Fruit of Vitex agnus-castus | Verified | Macroscopic ID / TLC |
| Agnuside (Iridoid Glycosides) | ≥ 0.5% (Customizable to 5%) | 0.62% | HPLC |
| Aucubin Content | ≥ 0.1% | 0.15% | HPLC |
| Appearance | Brown-yellow fine powder | Complies | Visual Assessment |
| Loss on Drying | ≤ 5.0% | 3.4% | USP <731> |
| Ash Content | ≤ 5.0% | 2.9% | USP <281> |
| Heavy Metals (Pb, As) | ≤ 2.0 ppm / ≤ 1.0 ppm | < 0.5 ppm / < 0.1 ppm | ICP-MS |
| Microbiology (Total Plate) | ≤ 1000 CFU/g | < 50 CFU/g | ISO 4833-1 |
Manufacturing & Processing Excellence
Targeted Iridoid Enrichment
Crude berry powders lack clinical predictability. Tihealth utilizes advanced macroporous resin column chromatography to specifically isolate and enrich Agnuside and Aucubin. This ensures every batch meets stringent pharmaceutical-grade standardization for reliable endocrine modulation.
Volatile Oil Preservation
The therapeutic efficacy of Vitex is heavily reliant on its volatile essential oils (e.g., limonene, 1,8-cineole). We implement a strict low-temperature vacuum extraction protocol that prevents the thermal degradation and volatilization of these critical synergistic compounds.
Zero Toxic Solvent Residues
Women's health formulations demand absolute purity. We strictly abandon harsh industrial solvents like Methanol, utilizing only a food-grade Ethanol-Water system. Rigorous evaporation techniques ensure solvent residues remain virtually undetectable (<50ppm).
Evidence-Based Pharmacological Mechanisms
Endocrine Modulation (HPA Axis)
While entirely hormone-free itself, Chaste Berry extract acts as a dopaminergic agonist. It modulates the pituitary gland to stimulate the production of luteinizing hormone (LH) while gently inhibiting follicle-stimulating hormone (FSH). This mechanism naturally enhances progesterone synthesis, restoring the estrogen-progesterone equilibrium.
Prolactin Inhibition & Mastalgia Relief
Excessive estrogen and elevated prolactin levels are primary triggers for cyclical mastalgia (breast tenderness) and breast tissue hyperplasia. By binding to dopamine D2 receptors, Vitex effectively normalizes prolactin secretion, significantly alleviating premenstrual breast discomfort.
Premenstrual Syndrome (PMS) Alleviation
Extensive clinical trials confirm that daily supplementation of concentrated Vitex extract significantly reduces the severity of PMS and Premenstrual Dysphoric Disorder (PMDD) symptoms, including mood volatility, irritability, hormone-induced headaches, and dysmenorrhea.
Dermatological Regulation (Hormonal Acne)
By mitigating androgen dominance and stabilizing hormonal fluctuations throughout the menstrual cycle, the extract acts internally to reduce excessive sebum production, thereby assisting in the long-term management of cystic, hormonal acne.
Industrial Formulation Applications
Women's Health Nutraceuticals
The premier botanical API for formulating cycle-regulating capsules, PMS-relief tablets, and menopause-transition supplements (often synergized with Evening Primrose or Dong Quai).
Functional Teas & Gummies
Due to its fine particle size and stability, it is increasingly incorporated into "Women's Wellness" functional gummies, tincture drops, and adaptogenic herbal tea blends.
Cosmeceuticals & Nutricosmetics
Utilized both as an oral "beauty-from-within" supplement for clearing hormonal acne and as a topical active in sebum-regulating skincare serums.
Pharmaceutical Intermediates
Serves as a highly standardized natural intermediate for the research and development of non-synthetic treatments for hyperprolactinemia and corpus luteum insufficiency.
Contract Manufacturing & Global Supply Chain
♦ Precise Active Customization
We strictly tailor the purity of Agnuside (from 0.5% up to 5.0% HPLC) to meet your specific therapeutic claims and budgetary requirements for dietary supplement lines.
♦ Traceable Quality Control
Every batch undergoes strict cGMP-certified analysis. We provide full COAs, ensuring heavy metals, pathogens, and pesticide residues strictly comply with stringent USP/EP and FDA standards.
♦ Strict Brand Confidentiality
Secure IP protection via NDAs. We offer blind shipping, private label bulk packaging (1kg foil bags to 25kg drums), and full regulatory documentation support for global customs clearance.
Packaging, Logistics & Secure Payment
Reliable B2B Supply Chain Solutions
We provide pharmaceutical-grade aseptic packaging, efficient global logistics (Air/Sea freight with dual customs clearance), and secure multi-currency payment methods to ensure seamless, oxidation-free cross-border transit for our B2B procurement partners.
Formulator & Procurement FAQ
01. Does your Vitex Extract contain actual hormones (like estrogen)?
No. Chaste Berry Extract is 100% hormone-free. Its efficacy comes entirely from its natural phytochemicals (like Agnuside and Aucubin) that indirectly modulate the pituitary gland, gently prompting the body to regulate its own endocrine balance naturally.
02. Are there any formulation contraindications we should warn consumers about?
Yes. While generally recognized as safe (GRAS) for adult populations, formulators should include standard cautionary labeling advising against its use by pregnant or lactating women (as it inhibits prolactin). It may also interact with dopamine-agonists or hormone replacement therapies.
03. Is the extract completely water-soluble for beverage applications?
Standard Vitex extracts have limited water solubility due to their active diterpenoid and essential oil content. For clear beverage or tea applications, we recommend discussing a custom micro-emulsified or highly purified water-soluble modification with our R&D team.
04. How do you analyze and ensure the exact Agnuside content?
We do not rely on simple gravimetric ratios. We utilize High-Performance Liquid Chromatography (HPLC) paired with certified reference standards to precisely quantify the Agnuside percentage, providing undeniable proof of potency on every COA.
05. What is the Minimum Order Quantity (MOQ) and packaging standard?
Our standard MOQ for mass production is 25kg, packed in heavy-duty cardboard drums lined with double sterile, nitrogen-flushed bags to prevent moisture ingress. We also supply 1kg foil bags for pilot manufacturing and R&D trials.
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