Hazelnut Extract
Main ingredients: Hawthorn acid, Hawthorn flavonoids
Product mesh: 80-100 mesh
Detection method: UV
Product Appearance: Brown Fine Powder
Extraction process: Hawthorn extract - purified water extraction
Specification: 20% -80%
Storage conditions: sealed and shaded, dry, cool and ventilated
Packaging method: 1KG/aluminum foil bag; 25KG/cardboard box
Shelf life: 24 months
Pharmaceutical-Grade Hawthorn Extract (Total Flavonoids)
Manufactured by Xi'an Tihealth Biotechnology Co., Ltd.
Xi'an Tihealth is a premier global B2B supplier of highly purified Hawthorn Extract (Crataegus pinnatifida). Distinct from culinary berry powders, our industrial-grade extract is meticulously sourced from the premium leaves, flowers, and mature berries of the Hawthorn plant, ensuring an exceptionally dense profile of bioactive phytochemicals.
Through our advanced composite enzymatic hydrolysis and macroporous resin adsorption protocols, we successfully isolate and concentrate the plant's core therapeutic compounds: Total Hawthorn Flavonoids (including Vitexin, Rutin, and Hyperoside). Standardized to rigorous purity specifications (ranging from 5% to 80% UV/HPLC), our fine brown-red powder demonstrates profound efficacy in enhancing coronary blood flow, neutralizing oxidative stress, and regulating lipid metabolism. It serves as an indispensable Active Pharmaceutical Ingredient (API) for premium cardiovascular-support nutraceuticals, blood pressure management capsules, and advanced metabolic health formulas.
Technical Data Sheet (TDS) & Analytical Control
| Analysis Item | Target Specification | Result (Typical Batch) | Methodology |
|---|---|---|---|
| Botanical Source | Leaves & Fruit of Crataegus pinnatifida | Verified | Macroscopic ID / TLC |
| Total Flavonoids | 5.0% - 80.0% (Customizable) | 21.5% | UV Spectrophotometry |
| Vitexin-2"-O-rhamnoside | ≥ 2.0% | 2.6% | HPLC |
| Appearance | Brown-red to light yellow fine powder | Complies | Visual Assessment |
| Loss on Drying | ≤ 5.0% | 3.8% | USP <731> |
| Ash Content | ≤ 5.0% | 3.1% | USP <281> |
| Heavy Metals (Pb, As) | ≤ 2.0 ppm / ≤ 1.0 ppm | < 0.5 ppm / < 0.1 ppm | ICP-MS |
| Microbiology (Total Plate) | ≤ 1000 CFU/g | < 100 CFU/g | ISO 4833-1 |
Manufacturing & Processing Excellence
Macroporous Resin Adsorption
Crude hawthorn extracts contain high levels of inert pectins and sugars. Tihealth utilizes advanced macroporous resin chromatography. This targeted purification step effectively strips away heavy impurities, allowing us to selectively enrich the total flavonoids up to an industry-leading 80%.
Composite Enzymatic Hydrolysis
We deploy a sophisticated composite enzymatic treatment combined with ultrasonic-assisted extraction prior to separation. This safely breaks down rigid plant cell walls at lower temperatures, ensuring the delicate molecular structure of Vitexin and Rutin remains entirely intact and highly bioavailable.
Zero Toxic Solvent Residues
Cardiovascular formulations demand absolute purity. We strictly abandon harsh industrial solvents, utilizing only a food-grade Ethanol-Water system. Rigorous High Speed Counter Current Chromatography (HSCCC) ensures solvent residues remain virtually undetectable (<50ppm).
Evidence-Based Pharmacological Mechanisms
Cardiovascular Health & Vasodilation
Hawthorn flavonoids are scientifically validated to dilate peripheral and coronary blood vessels. By enhancing myocardial blood flow and improving oxygen utilization, the extract actively lowers blood pressure, strengthens cardiac output, and protects endothelial cells against ischemic damage.
Lipid Modulation & Hepatic Protection
Functions as a potent metabolic regulator. It actively reduces serum cholesterol and triglyceride levels while stimulating the excretion of bile acids. This dual-action mechanism prevents hepatic fat accumulation and provides significant support against atherosclerosis.
Profound Cellular Antioxidant Defense
The synergistic matrix of Vitexin and Hyperoside acts as a powerful free-radical scavenger. It significantly reduces malondialdehyde (MDA) content in serum and upregulates the endogenous activity of Superoxide Dismutase (SOD) and Glutathione Peroxidase (GSH-Px).
Neuroprotection & Cognitive Support
Emerging clinical data indicates that hawthorn flavonoids cross the blood-brain barrier to exert neuroprotective effects. They assist in improving cognitive function, counteracting neurological stress responses, and promoting healthy neurogenesis in aging populations.
Industrial Formulation Applications
Cardiovascular Nutraceuticals
The premier botanical API for formulating blood pressure management capsules, lipid-lowering tablets, and heart-health vitality supplements.
Pharmaceutical R&D
Extensively utilized in clinical research as an intermediate for treating ischemic heart disease, arrhythmias, and diabetic metabolic complications.
Premium Cosmeceuticals
Due to its potent anti-inflammatory and micro-circulation enhancing properties, it is highly valued in anti-aging serums and rosacea-soothing face creams.
Functional Foods & Additives
Acts as a natural antioxidant additive in the food industry to extend shelf life while providing functional metabolic benefits in energy bars and dietary drinks.
Contract Manufacturing & Global Supply Chain
♦ Precise Active Customization
We strictly tailor the purity of Total Flavonoids (from 5.0% up to highly concentrated 80% fractions) to meet your specific therapeutic claims and budgetary requirements for dietary supplement lines.
♦ Traceable Quality Control
Every batch undergoes strict cGMP-certified analysis via UV/HPLC. We provide full COAs, ensuring heavy metals, pathogens, and pesticide residues strictly comply with stringent USP/EP and FDA standards.
♦ Strict Brand Confidentiality
Secure IP protection via NDAs. We offer blind shipping, private label bulk packaging (1kg foil bags to 25kg drums), and full regulatory documentation support for global customs clearance.
Packaging, Logistics & Secure Payment
Reliable B2B Supply Chain Solutions
We provide pharmaceutical-grade aseptic packaging, efficient global logistics (Air/Sea freight with dual customs clearance), and secure multi-currency payment methods to ensure seamless, oxidation-free cross-border transit for our B2B procurement partners.
Formulator & Procurement FAQ
01. Do you test specifically for Vitexin?
Yes. While generic "Total Flavonoids" can be measured via UV spectrophotometry, we utilize HPLC to specifically quantify the concentration of Vitexin-2"-O-rhamnoside, providing undeniable proof of cardiovascular potency on our COA.
02. Is this extract completely free from nut allergens?
Absolutely. Hawthorn (Crataegus pinnatifida) is a fruit-bearing shrub, not a tree nut (like Hazelnut). Our facility operates under strict cross-contamination protocols, ensuring the product is 100% nut-free and allergen-safe for global distribution.
03. Is the powder soluble in water for clear beverage applications?
Due to the high concentration of specific flavonoids, standard high-purity extracts may exhibit slight turbidity in cold water. For RTD (Ready-To-Drink) functional beverage formulations requiring absolute clarity, please contact our R&D team for micro-emulsified modifications.
04. Does the extraction process use toxic chemical solvents?
No. We strictly abandon harsh industrial solvents. Relying on a highly controlled water and food-grade ethanol extraction system, combined with macroporous resin, we ensure solvent residues remain strictly <5000 ppm, conforming to global pharmaceutical safety standards.
05. What is the Minimum Order Quantity (MOQ) and packaging standard?
Our standard MOQ for mass production is 25kg, packed in heavy-duty cardboard drums lined with double sterile, nitrogen-flushed bags to prevent oxidation and moisture ingress. We also supply 1kg foil bags for pilot manufacturing and R&D trials.
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