Kaempferol Extract

Kaempferol Extract

Product Name: Kaempferol
Extraction source: Sophora japonica extract
Alias: Kaempferol-3 Kaempferol
Product Appearance: Yellow Powder
Product odor: Special odor
Detection method: HPLC
CAS number: 520-18-3
Product specifications: 10% -98%
Packaging method: 1KG/aluminum foil bag;
25KG/cardboard drum
Storage conditions: Store in a dry and cool place, away from sunlight and high temperatures.
Validity period: 24 months.
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Bulk Kaempferol Powder 98% Sophora Japonica Extract

Kaempferol Powder Bulk ≥98% | Sophora Japonica Extract

Xi'an Tihealth Biotechnology Co., Ltd. - Standardized Flavonol Aglycone Manufacturer

Kaempferol ≥ 98.0% (HPLC-USP Standardized) CAS: 520-18-3 | Free Aglycone ≥ 99% Ultra-Low Solvent Residue (USP <467>)

Xi'an Tihealth is a premier global cGMP manufacturer and wholesale supplier of high-purity Kaempferol Powder (CAS: 520-18-3). We isolate our compound exclusively from the mature fruits of Sophora japonica L. (Japanese Pagoda Tree) sourced from GAP-certified botanical bases, avoiding the synthetic contaminants and variable compositions found in cheap or adulterated alternatives.

To satisfy the rigorous safety requirements of global pharmaceutical and advanced nutricosmetic brands, we utilize a highly controlled acidic hydrolysis protocol to cleanly cleave glycoside bonds, converting raw bonded sugars into highly bioavailable, free-form Kaempferol Aglycones (≥98.0% via HPLC-USP validation). Processed using food-grade ethanol and Supercritical CO₂ fluid polishing, this yellow crystalline powder features optimized bulk density and anti-static flowability, tailored specifically for automated solid-dose (capsules/tablets) formulations.

 

Technical Data Sheet (TDS) & Analytical Control

 

Analytical Parameter Target Specification Limit Typical Batch Result Validated Methodology
Taxonomic Botanical Source Mature fruit of Sophora japonica L. Verified Macroscopic / TLC ID
Kaempferol Assay (HPLC) ≥ 98.0% (Dry Basis) 98.63% HPLC (USP <621>)
Chemical Identification CAS: 520-18-3 / Formula: C15H10O6 Conforms FTIR & MS Spectroscopy
Free Aglycone Ratio ≥ 99.0% (Unbound Kaempferol) 99.45% HPLC Quantitative Cleavage
Physical State Yellow fine crystalline powder (100% through 80 mesh) Complies Visual / Sieve Analysis
Bulk / Tap Density 0.35g/ml - 0.55g/ml 0.43g/ml USP <616>
Residual Solvents (Class 2/3) Ethanol ≤ 10 ppm (0.001%) / Others: ND < 5 ppm Headspace GC-FID (USP <467>)
Heavy Metals (Pb, As, Cd, Hg) Pb ≤ 0.5 ppm, As ≤ 1.0 ppm (California Prop 65) Complies ICP-MS

 

Manufacturing & Processing Excellence

 

Supercritical CO₂ Concentration

Standard solvent extractions struggle to concentrate pure Kaempferol without co-extracting sticky plant lipids. Tihealth deploys advanced Supercritical CO₂ fluid extraction technology. This process selectively concentrates specific flavonoid fractions under high pressures, establishing a pristine and highly reliable ≥98.0% HPLC purity foundation.

Quantitative Aglycone Hydrolysis

Naturally occurring Kaempferol resides strictly as bound glycosides with massive molecular sizes. We implement a precise, temperature-controlled biological acid hydrolysis protocol (80°C - 85°C). This effectively breaks the esterified sugar rings, producing a free-form, highly active, and bioavailable Kaempferol aglycone matrix.

Trace Solvent and Endotoxin Control

Clinical formulations demand exceptional purity. We strictly utilize food-grade, multi-distilled ethanol as the crystallizing solvent, followed by low-temperature vacuum Decompression. This guarantees that residual solvents remain practically undetectable (≤10 ppm), safely satisfying European Directive and USP <467> thresholds.

 

Evidence-Based Pharmacological Mechanisms

 

01

Osteoblast Proliferation Support & Bone Kinetics

Through high-affinity estrogen receptor (ER) binding, free-form Kaempferol acts as a potent osteogenic promoter. It actively stimulates the alkaline phosphatase (ALP) activity of osteoblasts, upregulating runx2 gene transcription to accelerate collagen synthesis. This cellular signaling directly supports bone mineralization, offering an optimal active intermediate for advanced bone density formulations.

02

Advanced Glycation End-Products (AGEs) Inhibition

As a highly standardized flavonol aglycone, Kaempferol demonstrates profound free-radical scavenging capacity. It directly inhibits the formation of Advanced Glycation End-products (AGEs) and downregulates pro-inflammatory markers (specifically TNF-α and NF-κB pathways), protecting systemic vascular tissue from high-glucose-induced oxidative stress.

03

SIRT1 / AMPK Pathway Activation Support

Scientific research indicates that free Kaempferol regulates cellular longevity and mitochondrial dynamics by activating Silent Information Regulator 1 (SIRT1) and AMP-activated protein kinase (AMPK) pathways. This metabolic support assists in maintaining cellular energy homeostasis, indicating great potential in anti-senescence formulation pipelines.

 

Industrial Formulation Applications

 

Cardiovascular & Bone Health

The core phyto-ingredient for formulating osteoblast-stimulating bone density capsules, joint restoration blends, and arterial health supplements.

Anti-Senescence Complexing

Heavily utilized alongside Resveratrol and Quercetin in clinical longevity research and premium mitochondrial support supplements.

Enteral and Special Medical Diets

Formulated as a non-irritating natural antioxidant within clinical enteral diets (FSMP) to help regulate free-radical damage in recovering patients.

Dermal Permeation Systems

Employed as a high-potency topical ingredient in advanced anti-photoaging cosmeceuticals and barrier-defense creams to inhibit cellular sugar-crosslinking.

 

Contract Manufacturing & Global Supply Chain

♦ Precise Active Customization

We strictly tailor the crystallization process of Kaempferol (from 95% up to ultra-pure 98% HPLC specs) to perfectly match your specific formulation requirements, guaranteeing maximum bioavailability enhancement for your target compounds.

♦ Traceable Quality Control

Quality is mathematically verifiable. Every batch undergoes strict cGMP-certified analysis via HPLC. We provide full COAs, ensuring heavy metals, pathogens, and solvent residues strictly comply with USP and EP pharmacopeial standards.

♦ Secure Export Bulk Fulfillment

We specialize in global botanical logistics. We offer blind shipping, bulk packaging (from 1kg sealed foil bags to 25kg sterile commercial drums), and full FDA/EU regulatory documentation support for rapid global customs clearance.

 

 

Packaging, Logistics & Secure Payment

Reliable B2B Supply Chain Solutions

 

We provide pharmaceutical-grade aseptic packaging, efficient global logistics (Air/Sea freight with dual customs clearance), and secure multi-currency payment methods to ensure seamless, oxidation-free cross-border transit for our B2B procurement partners.

Pharmaceutical-Grade Extract Aseptic Drum Packaging
1
Global Sea and Air Freight Logistics for Plant Extracts
2
Secure B2B International Payment Methods
3

 

Formulator & Procurement FAQ

Q1: The global market contains synthetic Kaempferol sold as natural extract. How do you verify and guarantee the botanical origin of your ≥98% Kaempferol?

Adulteration of natural flavonoids with cheap synthetic coal-tar-derived aglycones is a severe regulatory risk for premium brands. Xi'an Tihealth guarantees 100% natural extraction exclusively from mature Sophora japonica L. fruits. We establish full batch-to-batch traceability from raw biomass to crystallites and verify origin authenticity via HPLC phytochemical fingerprinting and stable carbon isotope ratio analysis (δ13C), ensuring fully compliant documentation for high-end audit portfolios.

Q2: Free Kaempferol is often contaminated with unhydrolyzed glycosides (e.g., robinin) in low-grade extracts. What is your free-aglycone purification standard?

Unhydrolyzed glycosides significantly increase the molecular size of the material, diluting active purity and skewing absorption kinetics in dietary formulations. Our production system utilizes a highly calibrated acidic cleavage process that ensures a **free aglycone ratio of ≥99.0%**. High-Performance Liquid Chromatography (HPLC) is employed to verify that residual, heavy sugar-linked glycoside peaks are practically non-detectable, ensuring pure, uncompromised bioavailability.

Q3: Kaempferol is practically insoluble in water, which limits its use in liquid formulas. What formulation supports can Tihealth provide?

Due to its hydrophobic aglycone molecular structure, pure Kaempferol exhibits poor aqueous solubility, causing immediate sedimentation. For brands developing RTD wellness liquids, cosmetic serums, or effervescent tablets, our R&D team can deliver customized **liposomal encapsulation** or **cyclodextrin-complexed water-soluble Kaempferol** specs, which exponentially increase dispersion stability and aqueous kinetics without compromising molecule potency.

Q4: Standard flavonoid purifications often rely on Class 1 or Class 2 toxic solvents. What is your solvent residue control?

To comply with the ultra-strict safety rules of the United States Pharmacopeia (USP <467>) and the European Pharmacopoeia (EP 5.4), we do not use toxic chlorinated hydrocarbons or aromatic solvents. Our purification system operates strictly using eco-certified Supercritical CO₂ fluid polishing and food-grade ethanol as the sole crystallization phase. Decompression vacuum drying guarantees that residual ethanol is consistently kept **under 10 ppm (0.001%)**, which is virtually non-detectable.

Q5: High-purity crystalline powders frequently generate static charges during encapsulation. How do you control the physical rheology of Kaempferol?

Static charge buildup is a common manufacturing challenge that causes crystalline powders to adhere to machine hoppers and nozzles, resulting in uneven dosing weights. Tihealth addresses this by integrating a specialized crystal habit modification phase during low-temperature precipitation, which stabilizes the polymorph state. Combined with precision micro-milling and anti-static screening to achieve a uniform 80-mesh size and balanced bulk density (0.35-0.55 g/ml), our powder ensures excellent flowability on automated solid-dose production lines.

 

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