Uridine-5'-Monophosphate API CAS 58-97-9
Product source: Fermentation / Enzymatic conversion
Content specification: ≥ 98%
CAS number: 58-97-9
Testing method: HPLC
Active ingredient: Uridine-5'-monophosphate
Product packaging: 1kg/bag; 25kg/drum
Product storage: Sealed, cool, dry & dark place, avoid moisture & heat
Shelf life: 24 months
Uridine-5'-Monophosphate (UMP) API | CAS 58-97-9 | Synaptic Repair Catalyst
Uridine-5'-Monophosphate (UMP) is a critical nucleotide precursor synthesized via advanced fermentation and enzymatic conversion. At Xi'an Tihealth, we provide a high-specification UMP (CAS No. 58-97-9) with a validated HPLC purity of ≥ 98.0%. As a rate-limiting intermediate in the Kennedy Pathway, UMP is essential for the synthesis of phosphatidylcholine (PC), a primary structural component of neuronal membranes. Optimized for cognitive recovery and neuro-regeneration research, our UMP exhibits superior bioavailability compared to standard uridine. This pharmaceutical-grade powder is engineered for high-end nutriceutical systems where precise modulation of synaptic density and neurite outgrowth is the primary R&D objective.
⚠️ REGULATORY COMPLIANCE & RESEARCH USE ONLY (RUO)
Professional Use Specification: This ≥ 98% Uridine-5'-Monophosphate is supplied exclusively as a raw material API powder for professional laboratory research and industrial nutriceutical manufacturing. It is NOT a finished consumer product.
Handling Protocol: UMP is sensitive to moisture and thermal stress, which may trigger phosphate bond hydrolysis. Xi'an Tihealth Biotechnology Co., Ltd. assumes no liability for unauthorized direct usage, non-compliant retail applications, or legal consequences arising from the misuse of this nucleotide active.
Biochemical Mechanism and Synaptogenesis Potentiation
Uridine-5'-Monophosphate facilitates cognitive homeostasis through targeted metabolic pathways in the Central Nervous System:
- Kennedy Pathway Activation: UMP is phosphorylated to UDP and UTP, providing the cytidine precursor necessary for the synthesis of CDP-choline. This drives the production of phosphatidylcholine, the foundational lipid bilayer of neuronal synapses.
- Neurite Outgrowth Stimulation: Research indicates that UMP supports the structural repair of neurons by promoting the arborization of dendrites and the formation of new synaptic bridges, particularly when co-formulated with Omega-3 fatty acids (DHA).
- Mitochondrial Support: UMP assists in the maintenance of mitochondrial membrane potential in neuronal cells, effectively acting as a bioenergetic buffer against oxidative stress-induced neuro-decline.
Uridine-5'-Monophosphate Technical Data Sheet (TDS)
| Parameter | Pharmaceutical Specification |
|---|---|
| Assay (HPLC, on Dry Basis) | ≥ 98.0% |
| CAS Number | 58-97-9 |
| Source | Fermentation / Enzymatic Conversion |
| Testing Method | High-Performance Liquid Chromatography (HPLC) |
| Residual Solvents | ICH Q3C Compliance (Low-residue guarantee) |
| Microbial Limits | Total Plate Count ≤ 1000 cfu/g |
Bench Note: UMP is highly hygroscopic. In a manufacturing environment, ensure strict humidity control (< 40% RH). Exposure to high temperatures during blending may initiate phosphate group degradation. We recommend cold-blending or immediate sealing in multi-layered moisture-proof packaging.
Global Research & R&D Procurement FAQ
The primary difference lies in pharmacokinetics. Standard uridine often undergoes rapid first-pass metabolism. UMP, with its phosphate group, exhibits superior absorption through the digestive tract and a more stable uptake into the brain, making it more effective at lower doses for cognitive research.
What is the significance of UMP in the "Kennedy Pathway"?
The Kennedy Pathway is the primary route for de novo phospholipid synthesis. UMP provides the nucleotide backbone for the conversion of choline into phosphatidylcholine. In synergistic models with DHA and Choline, UMP is the essential "bridge" that enables the physical creation of new synapse membranes.
How do you ensure the chemical stability of the phosphate bond in UMP?
At Xi'an Tihealth, we utilize a specialized lyophilization/spray-drying hybrid process following enzymatic conversion. This maintains the crystalline integrity and ensures that the 5'-phosphate bond remains stable over the 24-month shelf life, provided the material is stored away from direct moisture and heat.
Xi'an Tihealth Biotechnology Compliance Statement: Nucleotide raw material API for industrial R&D only. User assumes all risks for unauthorized usage. ISO 9001:2015 Certified.
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