NALT API Powder CAS 537-55-3
Product source: Synthetic
Content specification: ≥99% (HPLC)
CAS number: 537-55-3
Testing method: HPLC
Active ingredient: N-Acetyl-L-tyrosine
Molecular formula: C₁₁H₁₃NO₄
Molecular weight: 223.23
Appearance: White to off-white crystalline powder
Solubility: Water-soluble ~10–25 mg/mL
Product packaging: 1kg/bag; 25kg/drum
Product storage: Sealed, cool, dry & dark place (15–25°C)
Shelf life: 24 months
NALT API Powder | CAS 537-55-3 | High-Solubility Dopamine Precursor
N-Acetyl L-Tyrosine (NALT) is a premium acetylated derivative of the amino acid L-tyrosine, specifically engineered to overcome the severe solubility constraints of the parent compound in aqueous mediums. At Xi'an Tihealth, we provide a pharmaceutical-grade NALT (CAS No. 537-55-3) with a validated HPLC purity of ≥ 99.0%. While standard L-tyrosine exhibits poor solubility (approx. 0.45 mg/mL), NALT achieves an industrial-leading solubility profile of 10–25 mg/mL. This significant enhancement makes NALT the foundational active ingredient for high-performance RTD nootropic beverages and liquid cognitive boosters, ensuring no sedimentation, high clarity, and rapid bioavailability as a strategic precursor for dopamine and norepinephrine under acute metabolic stress.
⚠️ REGULATORY COMPLIANCE & RESEARCH USE ONLY (RUO)
Industrial Use Specification: This ≥ 99% N-Acetyl L-Tyrosine is supplied exclusively as a raw material API powder for professional laboratory research and industrial nutriceutical manufacturing. It is NOT a finished consumer product.
Formulator Responsibility: NALT must be correctly buffered within stable pH windows to manage deacetylation kinetics. Xi'an Tihealth Biotechnology Co., Ltd. assumes no liability for unauthorized direct usage, non-compliant retail applications, or legal consequences arising from the misuse of this active ingredient.
Core Advantages for Industrial Formulation and Bio-Dynamics
- Superior RTD Compatibility: NALT eliminates the "chalky" residue and sedimentation common in liquid formulas using standard tyrosine. Its 20-50x increase in solubility ensures clarity and mouthfeel integrity in functional energy shots and carbonated nootropic drinks.
- Metabolic Rate-Limiting Buffer: NALT is converted to L-tyrosine via the enzyme Aminoacylase-1 (predominantly in the kidney). This provides a sustained release of catecholamine precursors, preventing the "dopamine crash" associated with acute mental fatigue and high-cortisol environments.
- Chemical Stability (N-Acetylation): The N-acetyl group protects the amino acid from premature degradation during industrial heat treatment (pasteurization), ensuring that the active payload remains intact throughout the 24-month shelf life.
NALT Technical Data Sheet (TDS) & Analytical Profile
| Analytical Parameter | Pharmaceutical Specification |
|---|---|
| Assay (HPLC, Anhydrous) | ≥ 99.0% (Active Compound) |
| CAS Number | 537-55-3 |
| Molecular Formula / Weight | C11H13NO4 / 223.23 g/mol |
| Water Solubility | ~10–25 mg/mL (at 25°C) |
| Specific Optical Rotation | +46.0° ~ +49.0° |
| Residual Solvents | ICH Q3C Compliance (Ethanol/Methanol < 500ppm) |
Formulator's Bench Note: NALT exhibits peak stability in formulations between pH 3.5 and 6.5. For liquid systems, maintaining this buffer prevents acid-catalyzed hydrolysis of the N-acetyl bond, ensuring consistent deacetylation kinetics post-consumption.
Global Research & R&D Procurement FAQ
The primary industrial hurdle for standard L-Tyrosine is its inability to dissolve in practical dosages for RTD beverages. NALT's high solubility allows for clear, concentrated dosages (up to 500mg+ per 60ml shot) without grit or fallout, satisfying the sensory and efficacy demands of premium nootropic brands.
What analytical documentation supports Xi'an Tihealth's NALT quality?
Every batch of Xi'an Tihealth NALT is accompanied by a comprehensive technical package: HPLC chromatograms for assay verification, Specific Optical Rotation reports for isomeric purity, and compliance certificates for heavy metals and residual solvents according to ICH Q3C standards.
How do deacetylation kinetics affect the product's cognitive timing?
NALT provides a sustained-release effect. Unlike free tyrosine, which is absorbed rapidly, the deacetylation of NALT by kidney aminoacylases provides a steady flux of tyrosine into the bloodstream, maintaining the catecholamine buffer for longer durations during high-stress mental tasks.
Xi'an Tihealth Biotechnology Compliance Statement: Synthetic raw material API for industrial R&D only. User assumes all risks for unauthorized clinical applications. ISO 9001:2015 Certified.
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