L-Theanine API CAS 3081-61-6
Product Source: Enzymatic Bio-Fermentation / Botanical Extraction
Content Specification: ≥ 99.0%
Chiral Purity: 100% L-Isomer
CAS Number: 3081-61-6
Testing Method: HPLC (Assay) & Polarimetry (Specific Rotation)
Product Packaging: 1kg / Aluminum foil bag ; 25kg / Pharmaceutical fiber drum
Product Storage: Store in a tightly sealed container; keep in a cool, dry, and well-ventilated area, away from direct sunlight and moisture.
Shelf Life: 24 months
L-Theanine API | ≥ 99% Fermentation Grade | Alpha Wave Inducer
L-Theanine (gamma-glutamylethylamide, CAS No. 3081-61-6) is a unique non-proteinogenic amino acid that acts as a structural analog of glutamine. At Xi'an Tihealth, we exclusively employ advanced enzymatic fermentation to ensure a 100% L-chiral structure, strictly avoiding the D-isomer impurities common in low-grade chemical synthesis. Standardized to ≥ 99.0% purity via HPLC, our L-Theanine is recognized for its exceptional ability to cross the blood-brain barrier (BBB). It is engineered for premium nootropic stacks and RTD functional beverages, providing a profound "wakeful relaxation" effect by inducing Alpha (α) brain waves while neutralizing the peripheral side effects of caffeine.
⚠️ REGULATORY COMPLIANCE & MANUFACTURING NOTICE
Research Use Only (RUO): This ≥ 99% L-Theanine is supplied exclusively as a raw material API powder for professional laboratory research and industrial nutriceutical manufacturing. It is NOT a finished consumer product.
Isomeric Integrity: D-Theanine is an inhibitory isomer that competes for gut absorption. Xi'an Tihealth guarantees a Zero D-Isomer profile through rigorous polarimetry validation. Xi'an Tihealth Biotechnology Co., Ltd. assumes no liability for unauthorized usage or non-compliant handling in retail sectors.
Biochemical Mechanism: Alpha Wave Induction and GABA Synergy
L-Theanine facilitates neuro-cognitive homeostasis through targeted molecular interactions in the CNS:
- Alpha (α) Wave Generation: By easily traversing the BBB, L-Theanine stimulates 8-12 Hz brain wave activity. This frequency is the neurological hallmark of "relaxed alertness," effectively mitigating psychological stress without sedative-induced drowsiness.
- The "Caffeine Buffer" Effect: In nootropic formulations (typically at a 2:1 ratio), L-Theanine antagonizes the vasoconstrictive and jitter-inducing effects of caffeine, ensuring a sustained, laser-like focus without the subsequent energy crash.
- Glutamate Receptor Competition: L-Theanine competitively binds to specific glutamate receptors (AMPA, Kainate), providing a neuroprotective effect against excitotoxicity and oxidative stress in the neuronal lipid bilayer.
L-Theanine Technical Data Sheet (TDS) & Analytical Audit
| Analytical Item | Specification | Methodology |
|---|---|---|
| L-Theanine Assay | ≥ 99.0% (Dry Basis) | HPLC |
| Specific Rotation [α]D20 | +7.0° ~ +8.5° (Verified L-Isomer) | Polarimetry |
| Appearance | White crystalline powder | Sensory Audit |
| Heavy Metals (Total) | ≤ 10 ppm | ICP-MS |
| Loss on Drying | ≤ 0.5% | USP <731> |
Formulation Bench Note: Our fermentation-grade L-Theanine is 100% water-soluble, yielding a clear, precipitate-free solution. It is ideally suited for RTD functional energy drinks and coffee-based nootropics where sensory clarity and flavor neutrality are mandatory.
Procurement & Formulation FAQ
Synthetic theanine often results in a 50/50 racemate containing D-theanine, which lacks the cognitive benefits of the L-isomer and can compete for absorption. Our enzymatic fermentation ensures a 100% natural-identical L-chiral structure, maximizing neurological efficacy and safety.
What is the recommended dosage for a "Smart Drug" caffeine stack?
Industry consensus for nootropic R&D suggests a 2:1 ratio (e.g., 200mg L-Theanine to 100mg Caffeine). This synergy leverages the focus of caffeine while the L-Theanine induces Alpha waves to stabilize mood and prevent vasoconstriction.
Xi'an Tihealth Biotechnology Compliance Statement: Pharmaceutical-grade raw material API. For industrial R&D only. User assumes all risks for unauthorized usage. ISO 9001:2015 Certified.
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