High-Purity N-Methyl-D-alanine API (CAS 29475-64-7)

N-Methyl-D-alanine (CAS No. 29475-64-7) is a highly specialized chiral amino acid derivative functioning as a critical building block in complex organic synthesis and pharmaceutical development. As a premier raw material supplier, Xi'an Tihealth provides this compound as a white crystalline powder with a validated HPLC purity of ≥99.0%. Due to its exceptional stereochemical stability and specific biological activity as an NMDA receptor modulator, it is strategically utilized across pharmaceutical intermediate synthesis, advanced fine chemicals, and targeted sports nutrition R&D.

Our quality control laboratory ensures that every batch of N-Methyl-D-alanine meets rigorous pharmaceutical and chemical standards. Below are the key analytical identifiers:

As a highly pure chiral molecule, N-Methyl-D-alanine offers multifaceted utility across various B2B sectors:

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• Pharmaceutical Intermediates: Acts as a crucial stereochemical building block for asymmetric synthesis, particularly in the development of novel peptide drugs and NMDA receptor-targeted therapeutics.
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• Neurological R&D: Extensively utilized in laboratory settings as an NMDA receptor agonist to study glutamate neurotransmitter systems and neuroplasticity mechanisms.
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• Sports Nutrition Formulation: Evaluated in precursor formulations aimed at endocrine modulation (e.g., luteinizing hormone pathways) and optimizing muscle carnosine levels during formulation research.

In preclinical contexts, the mechanism of action for N-Methyl-D-alanine is primarily observed through:

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• Receptor Modulation: It acts as a selective agonist at the N-methyl-D-aspartate (NMDA) receptor, working synergistically with glutamate to facilitate calcium ion influx and enhance neuronal signaling pathways.
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• Endocrine Interaction: Laboratory data suggests interactions with the hypothalamic-pituitary-gonadal axis, providing a mechanism for regulating anabolic hormone balance.
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• Cellular Protection: Exhibits potential in inhibiting specific pro-inflammatory signaling pathways (e.g., NF-κB) and modulating oxidative stress profiles in vitro.

The addition of the N-methyl group significantly alters the molecule's lipophilicity and receptor binding affinity. N-Methyl-D-alanine specifically demonstrates heightened selectivity and agonistic action at NMDA receptors compared to standard D-Alanine.

2,Can this chiral intermediate be used for peptide synthesis?

Yes, its high enantiomeric purity and chemical stability make it an excellent chiral building block for solid-phase peptide synthesis (SPPS) and the development of stereospecific peptide therapeutics.

3,Do you provide commercial bulk quantities for this CAS 29475-64-7 product?

Absolutely. Xi'an Tihealth supports both laboratory scale (gram to kilogram levels) for formulation R&D, and commercial bulk quantities with full COA and analytical documentation.