Acetyl Tetrapeptide-5 API Powder CAS 820959-17-9
Acetyl Tetrapeptide-5 API | CAS 820959-17-9 | Periorbital Microcirculation Enhancer
Acetyl Tetrapeptide-5 (commercially known as Eyeseryl) is a highly specialized synthetic tetrapeptide engineered to address the physiological drivers of periorbital edema and dark circles. At Xi'an Tihealth, we provide a high-specification API (C20H28N8O7) synthesized via Solid-Phase Peptide Synthesis (SPPS) with a validated HPLC purity of ≥98.0%. Unlike conventional drainage agents, this peptide functions as a targeted inhibitor of vascular permeability and an antiglycation agent. It is specifically designed for high-end eye-care systems where precise control over hemodynamic flux and collagen cross-linking is required to achieve a verifiable clinical reduction in eye-bag volume.
⚠️ REGULATORY COMPLIANCE & RESEARCH DISCLAIMER
Research Use Only (RUO): This product is supplied exclusively as a raw material powder for professional laboratory research and industrial pharmaceutical manufacturing. It is NOT a finished consumer product and is strictly prohibited for direct human application or ingestion in its current form.
Risk Assumption: The user assumes all responsibility for formulating this API. Misuse, including direct skin contact without clinical buffering or improper electrolyte balance, may result in irritation or failure. Xi'an Tihealth Biotechnology Co., Ltd. assumes no liability for unauthorized usage or non-compliant handling.
Biochemical Mechanism and Vascular Permeability Control
Acetyl Tetrapeptide-5 attenuates eye-bag formation through a dual-action pathway targeting liquid retention and tissue elasticity:
- Anti-Edema Pathway: The peptide inhibits the activity of Angiotensin-Converting Enzyme (ACE), thereby reducing capillary permeability in the sensitive periorbital region. This prevents the extravasation of fluids into the interstitial space, significantly lowering the volume of eye bags.
- Antiglycation Protection: It interferes with the cross-linking of collagen fibers by preventing the glycation process. By maintaining the flexibility of the dermal matrix, it ensures that the skin remains resilient enough to support local hemodynamic flux without collapsing.
- Drainage Optimization: Clinical research suggests that regular application in an optimized delivery vehicle promotes lymphatic drainage, reducing the appearance of dark circles caused by blood stasis and hyperpigmentation.
Formulation Parameters and Ionic Concentration Audit
To maintain the biological activity of Acetyl Tetrapeptide-5, formulators must adhere to strict biophysical parameters during the manufacturing phase:
| CAS Number | 820959-17-9 |
| HPLC Purity | ≥ 98.0% (Validated via RP-HPLC) |
| Molecular Weight | 492.5 g/mol (Below 500 Da for superior penetration) |
| Ionic Sensitivity | High; Requires tight osmotic pressure control |
| Residual Acetic Acid | ≤ 8.0% (Prevents formulation pH crashing) |
Bench Note: This is a pH-sensitive additive. The final bulk phase must be buffered between pH 5.0 and 7.0. High ionic strength (salinity) in the emulsion may trigger peptide aggregation or loss of anti-edema potency. Integrate at temperatures below 35°C.
Global Research Procurement FAQ
As a small-molecule peptide, its quaternary stability depends on the dielectric constant of the solvent. High electrolyte concentrations (salts) can disrupt the hydration shell of the peptide, leading to conformational changes. In eye-care formulations, this often results in a "stinging" sensation for the end-user or a significant reduction in vascular permeability efficacy.
How does this peptide compare to Caffeine in managing dark circles?Caffeine primarily acts via vasoconstriction and temporary stimulant-based drainage. Acetyl Tetrapeptide-5 offers a more robust pharmacological approach by inhibiting the glycation of collagen and actively lowering vascular permeability. It addresses the root cause of edema (fluid leakage) rather than just providing temporary drainage.
What is the significance of the "Acetic Acid" control for eye-care formulations?Residual acetic acid from the synthesis phase is a common irritant. Our ≤ 8.0% limit is essential for eye-area applications to ensure the final product does not trigger lacrimation or periorbital erythema. Furthermore, it protects the viscosity of Carbomer-based eye gels from ionic collapse.
Does Xi'an Tihealth provide stability data for international regulatory filings?Yes. We provide a full technical package including HPLC chromatograms, MS data, and short-term stability reports. We support our global partners with Batch Manufacturing Records (BMR) to ensure compliance with the quality audits required for drug and high-end cosmetic registration.
Xi'an Tihealth Biotechnology Compliance Statement: Raw material API for industrial R&D and laboratory use only. User assumes all risks for unauthorized clinical applications.
Hot Tags: acetyl tetrapeptide-5 api powder cas 820959-17-9, China acetyl tetrapeptide-5 api powder cas 820959-17-9 manufacturers, suppliers, factory, hialuronato de sodio hialuronato sodico sodium hyaluronate, hyaluronic acid sodium salt, sodium hyaluronate, sodium hyaluronate dan hyaluronic acid, sodium retinoyl hyaluronate
You Might Also Like
Send Inquiry