Epitalon API Powder CAS 307297-39-8
Product source: Synthetic peptide
Content specification: Purity: ≥99% (Research grade); ≥99.5% (Pharmaceutical grade)
CAS number: 307297-39-8
Testing method: HPLC
Active ingredient: Ala-Glu-Asp-Gly (AEDG) tetrapeptide
Product packaging: 1kg/bag; 25kg/drum
Product storage: Powder: sealed, keep dry, avoid light, store at ≤-20°C
Shelf life: 24 months
Epitalon API Powder | CAS 307297-39-8 | Telomerase Activator
Epitalon (Epithalon) is a synthetic tetrapeptide composed of the amino acid sequence Ala-Glu-Asp-Gly (AEDG). Originally identified as a pineal gland bioregulator, it is now at the forefront of gerontology research for its capacity to upregulate telomerase activity and promote cellular longevity. At Xi'an Tihealth, we address the critical supply shortage in the high-end longevity supplement market by providing an ultra-pure, ≥ 99.0% lyophilized API. Synthesized under strict solid-phase peptide synthesis (SPPS) protocols, our Epitalon is engineered with precise control over crystalline polymorphism, ensuring maximum bioavailability for advanced sublingual and oral formulation research.
⚠️ REGULATORY COMPLIANCE & RESEARCH USE ONLY (RUO)
Industrial Specification: This ≥ 99% Epitalon powder is supplied exclusively as a raw material API for professional laboratory research, in-vitro testing, and industrial formulation development. It is NOT a finished diagnostic or therapeutic product for direct human consumption.
Handling Requirement: As a lyophilized peptide, the material is highly susceptible to thermal degradation and moisture. Xi'an Tihealth Biotechnology Co., Ltd. assumes no liability for off-label clinical usage or stability failures caused by improper storage outside the recommended -20°C parameter.
Molecular Pharmacology: Cellular Senescence Modulation
Epitalon influences cellular aging and systemic homeostasis through multi-targeted biochemical pathways:
- Telomerase Activation: Epitalon upregulates the expression of the telomerase catalytic subunit (TERT). By facilitating the elongation of telomeres at the ends of chromosomes, it delays the onset of replicative cellular senescence (the Hayflick limit).
- Pineal Gland & Melatonin Regulation: It mimics the action of epithalamin, a natural pineal peptide, restoring circadian rhythms by normalizing endogenous melatonin production, which is crucial for deep sleep architectures.
- Nrf2 Antioxidant Pathway: It enhances the activity of superoxide dismutase (SOD) and glutathione peroxidase via the Nrf2 signaling pathway, protecting cellular DNA and lipid bilayers from oxidative degradation.
Epitalon Technical Data Sheet (TDS) Profile
| Analytical Parameter | Specification | Methodology |
|---|---|---|
| Sequence | Ala-Glu-Asp-Gly (AEDG) | Sequence Verification |
| CAS Number | 307297-39-8 | Registry Verified |
| Assay (Purity) | ≥ 99.0% | HPLC |
| Appearance | White to off-white lyophilized powder | Visual Audit |
| Identification | Mass matches theoretical MS | Mass Spectrometry (MS) |
| Microbial & Endotoxin | Strictly compliant for sterile R&D use | LAL / Total Plate Count |
Formulation Bench Note: Crystalline polymorphism is a severe challenge in lyophilized peptides. Xi'an Tihealth utilizes a highly controlled freeze-drying cycle to ensure a uniform crystalline lattice. This specifically accelerates dissolution rates and enhances transmucosal permeability, which is vital for R&D teams developing sublingual delivery formats.
Global Procurement & Formulation FAQ
High-end anti-aging supplement brands frequently face stock-outs due to low-yield synthesis methods. Xi'an Tihealth operates scaled Solid-Phase Peptide Synthesis (SPPS) reactors. We provide reliable bulk supply (from 10g to kilogram scales) without compromising the ≥ 99% HPLC purity standard, ensuring your production lines remain active.
Yes. While peptides are notoriously fragile in the gastrointestinal tract, the tetrapeptide structure (AEDG) of Epitalon is exceptionally small. When combined with our specific lyophilization technique that standardizes crystalline polymorphism, it exhibits superior absorption kinetics for advanced sublingual drops or enteric-coated oral capsules.
Epitalon must be stored at -20°C in a dry, dark environment to ensure its 2-year shelf life. All bulk orders from Xi'an Tihealth are sealed under inert gas and shipped with temperature-controlled protection (cold chain logistics) to guarantee the API arrives at your facility intact.
Xi'an Tihealth Biotechnology Compliance Statement: Raw material API for industrial R&D only. Secure a reliable supply chain of high-purity, polymorphic-controlled Epitalon for advanced gerontology research.
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