Palmitoyl Pentapeptide-4 API CAS 214047-00-4
Product Name: Palmitoyl Pentapeptide-4 API Powder
Product source: Synthetic
Content specification: ≥ 98%
CAS number: 214047-00-4
Testing method: HPLC
Active ingredient: Palmitoyl Pentapeptide-4
Product packaging: 1kg/bag; 25kg/drum
Product storage: Store in a cool, dry, ventilated and dark place, avoid direct sunlight, high temperature (above 30℃) and humidity
Shelf life: 24 months
Palmitoyl Pentapeptide-4 API | CAS 214047-00-4 | Dermal Remodeling Messenger
Palmitoyl Pentapeptide-4 (CAS No. 214047-00-4) is a synthetic matrikine peptide comprising five amino acids (KTTKS) conjugated to a 16-carbon palmitic acid chain. At Xi'an Tihealth, we prioritize the biophysical reality of transdermal delivery; the palmitoylation is strategically engineered to bypass the skin's lipid-heavy gatekeeper, allowing the molecule to overcome the 500-Dalton barrier. Manufactured via optimized Solid-Phase Peptide Synthesis (SPPS) and purified through multi-stage preparative HPLC, our API achieves a validated purity of ≥99.0%. This pharmaceutical-grade powder functions as a biological messenger to trigger Extracellular Matrix (ECM) synthesis, providing a stable and clinical-grade alternative to Retinol for advanced anti-aging drug systems and dermatological research.
⚠️ CRITICAL REGULATORY COMPLIANCE NOTICE
Professional Research Use Only (RUO): This product is supplied exclusively as a raw material powder for use in professional laboratory research and industrial pharmaceutical manufacturing. It is NOT a finished cosmetic or medicinal product and is strictly prohibited for direct human use or consumption.
Risk Assumption: Any unauthorized use, including direct skin application without proper pharmaceutical formulation and clinical oversight, is at the user's sole risk. Xi'an Tihealth Biotechnology Co., Ltd. assumes no liability for adverse effects or legal consequences arising from non-compliant handling of this API.
Biochemical Mechanism and Extracellular Matrix Stimulation
Palmitoyl Pentapeptide-4 facilitates dermal remodeling through targeted fibroblast activation and signaling pathways:
- Matrikine Mimicry: The KTTKS sequence mimics a sub-unit of pro-collagen type I. Binding to specific fibroblast receptors signals the upregulation of collagen types I and IV, elastin, and glycosaminoglycans (GAGs).
- Lipophilic Permeation: With a molecular weight of 802.05 g/mol, the attached palmitoyl chain fluidizes the stratum corneum lamellae, overcoming the biophysical wall that repels hydrophilic solutes over 500 Daltons.
- Stability & Purity: We strictly monitor "deletion sequences" via HPLC to eliminate truncated fragments that can trigger immunogenic responses, ensuring the structural integrity of the peptide bonds during the synthesis phase.
Technical Specifications and Quality Management
| Molecule | Palmitoyl Pentapeptide-4 (KTTKS derivative) |
| Assay (HPLC Purity) | ≥ 99.0% (Strict control of deletion sequences) |
| Molecular Weight | 802.05 g/mol |
| Residual Acetic Acid | ≤ 8.0% (Prevents ionic collapse of polymer networks) |
| Microbial Limits | ≤ 100 cfu/g (Safe for professional R&D and microneedling research) |
Bench Notes: This is a cold-process additive. To prevent conformational degradation, integrate the peptide into the base at temperatures below 35°C. Buffer the bulk phase strictly between pH 5.5 and 6.0 using non-chelating systems.
Global Research Procurement FAQ
While Retinol is a potent collagen inducer, it often triggers inflammatory side effects. Palmitoyl Pentapeptide-4 stimulates the same extracellular matrix repair pathways without the inflammatory response, providing a stable and safer benchmark for long-term anti-aging studies and sensitive-skin research.
How do you manage the risk of viscosity loss in Carbomer-based formulations?Viscosity loss is typically caused by excessive residual acetic acid from the synthesis phase. High acid content drops the pH and spikes ionic strength, causing polymer networks to collapse. Xi'an Tihealth's ≤ 8.0% acid limit ensures the structural stability of your final emulsion or gel.
Does Xi'an Tihealth provide documentation for regulatory factory audits?Yes. We provide a full technical dossier, including the Certificate of Analysis (COA), Batch Manufacturing Records (BMR), and MSDS. Our quality team supports international regulatory audits to verify the absence of immunogenic deletion sequences in our API.
What defines the "500-Dalton Barrier" in transdermal peptide delivery?The skin barrier is biophysically optimized to repel solutes over 500 Da. At 802.05 Da, this peptide requires the palmitoyl fatty acid chain to fluidize the lipid lamellae. Without this lipophilic modification, the active KTTKS fragment cannot penetrate the dermis, rendering it ineffective.
Xi'an Tihealth Biotechnology Compliance Statement: Raw material API for industrial R&D and laboratory use only. Not for retail. All unauthorized usage is at the user's sole risk.
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