Kudzu Extract
English name: Pueraria extract
Latin name: Pueraria lobata (Willd.) Ohwi
Product specifications: ≥95%
Molecular formula: C21H20010
Molecular weight: 432.38
CAS: 3681-99-0
Extraction source: Root of Pueraria lobata, a leguminous plant
Storage conditions: This product should be sealed and shaded, and stored in a dry, cool, and well ventilated environment
Pharmaceutical-Grade Kudzu Extract (Puerarin & Isoflavones)
Manufactured by Xi'an Tihealth Biotechnology Co., Ltd.
Xi'an Tihealth is a premier global B2B manufacturer of highly purified Kudzu Root Extract. We rigorously source our botanical raw materials from the premium dried roots of Pueraria lobata (Willd.) Ohwi, cultivated in unpolluted, heavy-metal-free mountainous regions. Utilizing advanced continuous countercurrent extraction coupled with highly specific macroporous resin chromatography, we expertly isolate and concentrate the plant's core bioactive isoflavonoids-primarily Puerarin, Daidzein, and Daidzin.
To meet diverse industrial formulation requirements, we provide a highly customizable specification matrix ranging from cost-effective 40% Total Isoflavones for bulk dietary supplements, up to ultra-pure 98% Puerarin (HPLC validated) Active Pharmaceutical Ingredients (APIs). Clinically recognized globally for its profound cardiovascular hemodynamics (improving microcirculation), metabolic regulation (accelerating alcohol metabolism), and potent phytoestrogenic modulation, Tihealth's standardized Kudzu Extract is the foundational raw material for advanced heart-health formulas, anti-hangover supplements, and premium women's health nutraceuticals.
Technical Data Sheet (TDS) & Analytical Control
| Analysis Item | Target Specification | Result (Typical Batch) | Methodology |
|---|---|---|---|
| Botanical Source | Dried roots of Pueraria lobata | Verified | Macroscopic ID |
| Puerarin Assay | 10%, 30%, 60%, 98.0% | Conforms to Spec | HPLC / ChP |
| Total Isoflavones | ≥ 40.0% (Broad Spectrum) | 42.5% | UV Spectrophotometry |
| CAS / Molecular Formula | 3681-99-0 (Puerarin) / C21H20O9 | Matches Profile | Spectral Analysis |
| Appearance | Brownish-yellow to white crystalline powder | Complies | Visual Assessment |
| Solubility | Custom Water-Soluble Grades Available | Complies | Aqueous Dispersion |
| Loss on Drying | ≤ 5.0% | 3.6% | USP <731> |
| Heavy Metals (Pb, As) | ≤ 10.0 ppm / ≤ 2.0 ppm | < 5.0 ppm / < 0.5 ppm | ICP-MS |
| Solvent Residue (Ethanol) | ≤ 5000 ppm (EP/USP Limit) | < 500 ppm | GC-FID |
Manufacturing & Processing Excellence
Targeted Isoflavone Enrichment
Standard extracts often yield unstable, low-purity isoflavones heavily contaminated with plant starches. Tihealth utilizes a highly controlled, continuous countercurrent extraction protocol. This specific gradient ensures the maximum yield of Puerarin and related isoflavones while effectively leaving behind inert structural cellulose and heavy resins.
Macroporous Resin Purification
To achieve ultra-high pharmaceutical purities (≥98% Puerarin), the concentrated extract is subjected to patented AB-8 macroporous adsorption resin chromatography. This rigorous molecular sieving step flawlessly isolates the active Puerarin from inactive sugars and pigments, yielding a pristine, white to pale-yellow crystalline powder.
Water-Solubility Modification
Natural Puerarin is notoriously insoluble in water, limiting its use in beverages. Tihealth has engineered a proprietary structural modification process to produce a 100% water-soluble Kudzu Extract grade. It achieves rapid dissolution with zero precipitation, perfect for clear RTD (Ready-to-Drink) functional anti-hangover elixirs.
Evidence-Based Pharmacological Mechanisms
Cardiovascular Hemodynamics & Vasodilation
Puerarin functions as a highly potent cardiovascular agent. It actively dilates coronary and cerebral blood vessels, significantly increasing regional blood flow and improving microcirculation. This mechanism reduces myocardial oxygen consumption and acts as a primary clinical intervention for angina pectoris and sudden sensory neural hearing loss.
Hepatic Protection & Acetaldehyde Metabolism
Widely formulated in premium "anti-hangover" remedies, Kudzu extract accelerates the enzymatic clearance of blood alcohol. Specifically, it promotes the activity of aldehyde dehydrogenase (ALDH), rapidly degrading toxic acetaldehyde, thereby mitigating alcohol-induced hepatic (liver) oxidative stress and alleviating systemic hangover symptoms.
Endocrine Modulation (Phytoestrogen Activity)
The specific isoflavones (like Daidzein) within the extract possess a structural similarity to mammalian estrogen. They act as selective estrogen receptor modulators (SERMs), safely providing phytoestrogenic support. This mechanism effectively alleviates menopausal hot flashes and helps maintain bone mineral density without the severe risks associated with synthetic hormone replacement therapy.
Glycemic & Lipid Regulation
Exhibits significant capacity to modulate glucose metabolism and lower serum lipid profiles. By enhancing cellular insulin sensitivity and suppressing the release of pro-inflammatory cytokines, it provides targeted metabolic support for pre-diabetic and cardiovascular formulations.
Industrial Formulation Applications
Pharmaceutical Formulations (API)
The premier active ingredient (≥98% Puerarin) in clinical injectables and oral tablets targeting cardiovascular diseases, microcirculation disorders, and sudden deafness.
Anti-Hangover & Liver Support
Our water-soluble grades are heavily formulated into RTD functional beverages, wellness effervescent tablets, and hepatoprotective capsules for post-alcohol recovery.
Women's Health Nutraceuticals
Utilized extensively in dietary supplements designed for menopausal endocrine balance, breast health maintenance, and osteoporosis prevention.
High-End Cosmeceuticals
Applied as an active dermal conditioner in premium skincare serums and anti-aging lotions to leverage its robust antioxidant capacity and skin-barrier repair functions.
Contract Manufacturing & Global Supply Chain
♦ Precise Active Customization
We strictly tailor the concentration of Puerarin (from cost-effective 10% up to ultra-pure 98% HPLC specs) or Total Isoflavones to perfectly match your specific formulation budget and therapeutic targets.
♦ Traceable Quality Control
Quality is mathematically verifiable. Every batch undergoes strict cGMP-aligned analysis via HPLC. We provide full COAs and MSDS documentation, ensuring heavy metals, pathogens, and solvent residues strictly comply with USP and EP standards.
♦ Secure Export Bulk Fulfillment
We specialize in global botanical logistics. We offer blind shipping, bulk private label packaging (from 1kg foil bags to 25kg sterile drums), and full regulatory documentation support for rapid global customs clearance without delays.
Packaging, Logistics & Secure Payment
Reliable B2B Supply Chain Solutions
We provide pharmaceutical-grade aseptic packaging, efficient global logistics (Air/Sea freight with dual customs clearance), and secure multi-currency payment methods to ensure seamless, moisture-free cross-border transit for our B2B procurement partners.
Formulator & Procurement FAQ
01. Is the extract completely water-soluble for beverage applications?
Natural high-purity Puerarin exhibits low aqueous solubility. However, Tihealth has engineered a proprietary water-soluble grade specifically for the F&B industry. This specialized powder disperses rapidly in water, resulting in a clear, precipitate-free solution ideal for RTD functional anti-hangover drinks.
02. What concentrations of Puerarin do you manufacture in bulk?
As a direct factory, we produce a full spectrum of standardized Kudzu extracts. Our regular bulk inventory includes 10%, 30%, 60%, and highly purified 98% Puerarin (strictly analyzed via HPLC) to suit varying formulation budgets and R&D clinical requirements.
03. Does the extraction process use harsh chemical solvents?
No. We employ a controlled, continuous countercurrent extraction utilizing a safe ethanol-water system, followed by specific macroporous resin purification. This ensures the structural integrity of the isoflavones while guaranteeing that residual solvents remain strictly below 5000 ppm (EP/USP Limit).
04. Can you guarantee the product is free from heavy metals?
Absolutely. We source our Kudzu roots from unpolluted, ecologically audited cultivation zones. Every batch is verified via ICP-MS to ensure that Total Heavy Metals remain strictly ≤ 10.0 ppm, fully complying with FDA and European safety regulations.
05. What is the Minimum Order Quantity (MOQ) and lead time?
Our standard MOQ for mass commercial production is 25kg, securely packed in heavy-duty commercial drums lined with sterile, moisture-proof bags. We also supply 1kg bespoke MOQ sizes for pilot manufacturing and stability trials. Standard global dispatch is within 7-10 days.
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