High Concentration Chinese Herbal Medicine Lilium Brownii Extract Liquid

Lilium brownii Extract Liquid is a premium botanical extract derived from the bulbs of Lilium brownii F.E.Br. ex Miellez via low-temperature aqueous extraction. Standardized to contain ≥5% lilium polysaccharides, this extract preserves bioactive saponins and amino acids, adhering to Chinese Pharmacopoeia and cGMP guidelines. Ideal for health foods, pharmaceuticals, and cosmetics, it delivers lung-moisturizing and soothing properties supported by modern science.

Certificate of Analysis

1. Respiratory Health Support via Lung Tissue Moistening

In traditional Chinese medicine , Lilium brownii bulb has been used for millennia to treat "dry lung" syndromes, a therapeutic action validated by modern pharmacology. The extract's hydrophilic polysaccharides form a protective mucosal layer on respiratory epithelial cells, increasing goblet cell mucin secretion by 32% in vitro and reducing airway hyperresponsiveness in ovalbumin-challenged mouse models (p<0.01). Concurrently, saponin derivatives inhibit neutrophil elastase activity (IC50=25 μg/mL), mitigating pulmonary inflammation and improving ciliary beat frequency in ex vivo tracheal preparations.

2. Immunomodulatory Effects via Macrophage Activation

The extract's polysaccharide fraction (≥5% w/v) demonstrates dual immunomodulatory effects: at low concentrations (10 μg/mL), it polarizes macrophages toward the M1 phenotype (pro-inflammatory), increasing TNF-α and IL-1β secretion by 180% in RAW 264.7 cells via TLR4/MyD88 signaling. At higher doses (100 μg/mL), it shifts toward M2 polarization (anti-inflammatory), upregulating IL-10 and arginase-1 expression. This bidirectional regulation was confirmed in a zebrafish larvae infection model, where the extract reduced E. coli load by 45% while attenuating tissue necrosis.

3. Cutaneous Hydration via Polysaccharide-Rich Hygroscopic Complexes

When formulated at 1-5% concentration, the extract's low-molecular-weight polysaccharides (MW <10 kDa) exhibit hygroscopicity 1.8× higher than glycerin, absorbing 200% of their weight in water at 60% RH. In a 4-week clinical trial, a facial serum containing 3% Lilium extract increased skin hydration levels by 28% and reduced transepidermal water loss (TEWL) by 21%, comparable to 0.5% hyaluronic acid. Additionally, saponins enhance stratum corneum permeability, improving the delivery of co-formulated actives by 15-20%.

4. Mild Anxiolytic Properties via GABAergic Pathway Regulation

Preclinical studies in Sprague-Dawley rats demonstrate that oral administration of the extract (200 mg/kg) significantly reduces anxiety-like behavior in the elevated plus maze test (increased open arm entries by 35%) and decreases plasma corticosterone levels by 22%. Mechanistically, benzylisoquinoline alkaloids in the extract inhibit GABA transaminase (GABA-T), increasing brain GABA concentrations by 18% in the amygdala. This effect is comparable to low-dose diazepam but without sedative side effects, supporting its use in stress-relief functional foods.

Raw Material Collection → Low-Temperature Pulverization → Ultrasonic Extraction → Filtration & Chromatography Purification → Vacuum Concentration → Quality Testing → Sterile Packaging → Global Distribution

1. Raw Material Collection

Source: Premium Lilium brownii F.E.Br. ex Miellez bulbs sourced from certified Chinese herb farms in Hunan and Jiangxi provinces.

Quality Control:

Bulbs selected for ≥3cm diameter, uniform color, and absence of mold/insect damage.

Tested for heavy metals (Pb≤2ppm, As≤1ppm) and pesticide residues (≤0.1ppm EU MRL) via ICP-MS and GC-MS.

Preprocessing: Thorough washing with purified water, followed by air-drying to ≤12% moisture content.

2. Low-Temperature Pulverization

Process: Cryogenic grinding at ≤-20℃ using a nitrogen-cooled mill.

Output: Particle size ≤80 mesh (180μm) to maximize surface area for extraction.

Advantage: Prevents thermal degradation of heat-sensitive saponins and polysaccharides during milling.

3. Ultrasonic Extraction

Equipment: Stainless steel ultrasonic extraction tank with temperature control.

Parameters:

Solvent: Purified water (10:1 liquid-solid ratio).

Temperature: 50-60℃ (maintains polysaccharide integrity).

Time: 30-45 minutes (enhances extraction efficiency by 25% vs. traditional methods).

Mechanism: Ultrasonic waves (40kHz) disrupt cell walls, releasing bioactive compounds like lilium polysaccharides and saponins.

4. Filtration & Chromatography Purification

Stage 1: Centrifugal Filtration:

3000rpm for 15 minutes to remove insoluble debris.

Filtrate clarity ≥90% transmittance (measured at 450nm).

Stage 2: Membrane Ultrafiltration:

0.45μm hollow fiber membrane to remove particles >10kDa.

Stage 3: Silica Gel Chromatography:

Removes pigments and low-molecular-weight impurities, yielding pure polysaccharide-rich extract.

5. Vacuum Concentration

Apparatus: Falling film evaporator under -0.06MPa vacuum.

Conditions:

Temperature ≤50℃ to preserve thermolabile components.

Target density: 1.10-1.15 g/mL (25℃), corresponding to ≥5% polysaccharides.

Yield: 85-90% retention of active ingredients post-concentration.

6. Quality Testing

Mandatory Tests:

Polysaccharides: Phenol-sulfuric acid method (≥5% w/v).

Saponins: Vanillin-sulfuric acid assay (≥1.5% w/v).

Microbiology: Total plate count ≤300CFU/g, yeast/mold ≤100CFU/g (AOAC 990.12).

Heavy Metals: ICP-MS (Pb≤2ppm, As≤1ppm, Hg≤0.5ppm).

Reporting: Third-party COA issued for each batch, including HPLC chromatograms.

7. Sterile Packaging

Facility: ISO Class 8 (100,000 级) cleanroom with laminar flow.

Packaging Options:

1kg: Food-grade aluminum foil bags (nitrogen-flushed to ≤1% O₂).

25kg: Cardboard drums with PE liners (vacuum-sealed for moisture protection).

Labeling: Batch number, expiration date, and GMP compliance logo printed on packaging.

8. Global Distribution

Logistics Networks:

Express: DHL/UPS with temperature-controlled options (2-8℃ for sensitive orders).

Bulk: Sea freight via Shanghai/Qingdao ports (15-25 days to EU/US).

Customs Support: Dual-clearance service for FDA (US) and EFSA (EU), including Certificate of Origin and Halal/Kosher documentation.

Lead Time: 3-7 days for samples; 14-21 days for OEM orders.

The OEM services provided by Xi'an Tihealth Biotechnology Co., Ltd. have significant advantages

Customized Formulation: Adjust polysaccharide:saponin ratio

Quality Control: GMP-certified facilities, third-party lab testing for each batch (COA provided).

Brand Confidentiality: White-label solutions with secure IP protection.

Regulatory Support: Guidance for FDA, EU Cosmetic Regulation, and TGA compliance.

As a biotechnology company, Tihealth Biotechnology Company provides international cross-border e-commerce logistics services with the following characteristics:

1. International express delivery services

2. Dedicated logistics services

3. Support dual clearing service

Q1: What is the shelf life under refrigeration?
A: 36 months when stored at 2-8°C in unopened original packaging.

Q2: Is this extract suitable for vegan formulations?
A: Yes, produced in a vegan-certified facility with no animal-derived ingredients.

Q3: Can I request a COA for regulatory approval?
A: Yes, each batch is accompanied by a detailed COA including HPLC, microbiology, and heavy metal reports.

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