Ziconotide Powder Cas No.107452-89-1
English alias: Prialt
Product source: artificially synthesized
Product specifications: ≥ 99%
CAS NO：107452-89-1
Detection method: HPLC
Active ingredient: Zyconomide Acetate
Product Description: White to off white freeze-dried powder
Product use: Intrathecal injection analgesic for the treatment of refractory chronic pain
Product packaging: 1mg-100mg/bottle; 10 bottles/box
Product storage: Store in the dark and dry environment at -20 ℃± 5 ℃
Shelf life: 24 months
Xi'an Tihealth Ziconotide Product Overview
Xi'an Tihealth Biotechnology provides high-purity Ziconotide (CAS 107452-89-1) with a core purity of ≥ 98% (HPLC), optimized for pharmaceutical research and clinical development. The product is supplied as a lyophilized powder, strictly maintained under -20℃ cold-chain conditions, and supported by comprehensive COA documentation. We offer customized pharmaceutical specifications ranging from milligram scales to commercial bulk, designed to support intrathecal drug delivery systems and refractory neuropathic pain therapeutic research.
Product Function
Refractory Pain Analgesia: Specifically blocks N-type voltage-gated calcium channels (Cav2.2) between nerve endings and spinal dorsal horn neurons, inhibiting pain signal transduction. Indicated for complex neuropathic pain where traditional opioid/NSAID protocols are ineffective.
Mechanism of Action
1. Targeted Inhibition: Selective binding to presynaptic N-type (Cav2.2) calcium channels in the spinal dorsal horn, effectively blocking calcium influx essential for neurotransmitter release.
2. Signaling Interruption: Down-regulates the synaptic release of excitatory nociceptive neurotransmitters (Substance P and Glutamate), effectively halting pain signal transmission to the central nervous system.
Products Application
• Clinical therapeutic analgesic drug manufacturing.
• Advanced neurological disease and neuropathic pain drug development.
• Specialized neuroscience R&D and mechanistic validation.
Pharmacological Effects
Clinical Profile:
✅ Non-Opioid Pathway: No risk of opioid addiction or physical dependency.
✅ Safety Profile: Minimal risk of respiratory depression compared to opioids.
✅ Tolerance Resilience: Significantly slower tolerance development, sustaining therapeutic efficacy over extended cycles.
FAQ
Q: What is the purity standard for Tihealth's Ziconotide API?
We provide Ziconotide API with a verified purity of ≥ 98% (HPLC analysis). Each batch is accompanied by an analytical certificate confirming the sequence identity via mass spectrometry and purity via chromatography.
Q: Does the product require special storage and shipping protocols?
Yes. As a sensitive peptide API, Ziconotide must be stored at -20℃. We utilize specialized cold-chain logistics to maintain molecular stability throughout international transit.
Q: Is this product suitable for clinical trials?
This product is an API designed for pharmaceutical formulation and R&D. It must be processed and administered within a regulated clinical GMP environment. We provide all necessary dossiers (COA/SDS) for institutional auditing.
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