Ziconotide Powder Cas No.107452-89-1
English alias: Prialt
Product source: artificially synthesized
Product specifications: ≥ 99%
CAS NO：107452-89-1
Detection method: HPLC
Active ingredient: Zyconomide Acetate
Product Description: White to off white freeze-dried powder
Product use: Intrathecal injection analgesic for the treatment of refractory chronic pain
Product packaging: 1mg-100mg/bottle; 10 bottles/box
Product storage: Store in the dark and dry environment at -20 ℃± 5 ℃
Shelf life: 24 months
Products Description
Xi'an Tihealth Ziconotide Product Overview
Our company provides high-purity ziconomide (CAS 107452-89-1) with a core purity of ≥ 98% (HPLC), which can meet market demand. The product is provided in the form of freeze-dried powder (white to off white), with full -20 ℃ cold chain transportation, equipped with complete COA, and supports customized pharmaceutical specifications ranging from 1mg to kg. This product is specifically designed for the development of analgesic formulations and is suitable for the research and GMP production of intrathecal drug delivery systems, helping customers overcome the bottleneck of refractory neuropathic pain treatment.
Products Function
Efficient analgesia: Specifically blocks N-type voltage-gated calcium channels (Cav2.2) between nerve endings and spinal dorsal horn neurons, inhibits pain signal transduction, and is suitable for refractory neuropathic pain that traditional analgesics are ineffective.
Mechanism of action
1. Target binding → Selective binding to Cav2.2 channels in the presynaptic membrane of spinal dorsal horn neurons → Blocking calcium influx
2. Signal inhibition → reduction of release of pain neurotransmitters such as substance P and glutamate → interruption of pain signal transmission to the central nervous system
Products Aplication
1. Applied in clinical treatment
2. Applied in the field of new drug research and development
3. Applied in the field of neuroscience research
Pharmacological effects
1. Effective time: 1-2 hours after intrathecal administration
2. Duration: 12-24 hours for a single administration (continuous infusion pump administration is required)
3. Therapeutic advantages:
✅ No addiction to opioid drugs
✅ No risk of respiratory depression
✅ Slow development of tolerance
Toxicological effects
|
Toxicity type |
Manifestation and Control measures |
|
Neurotoxicity |
Dose-dependent dizziness, blurred consciousness (can be controlled by strict titration dosage) |
|
Psychological side effects |
Hallucinations, depression (incidence about 12%, reversible upon discontinuation of medication) |
|
Contraindications |
Patients with a history of mental illness are prohibited from using it; Not suitable for intravenous/intramuscular injection (intrathecal only) |
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