Edotreotide Powder Cas No.204318-14-9
English alias: DOTATOC
Product source: artificially synthesized
Product specifications: ≥ 98%
CAS NO：204318 - 14 - 9
Detection method: HPLC
Active ingredient: Edotriotide
Product Description: White to off white freeze-dried powder
Product packaging: It is packaged in penicillin bottles with good sealing properties, and the packaging specifications are determined according to the product specifications
Product storage: Store at a low temperature of -20 ℃, away from light.
Avoid repeated freezing and thawing.
Shelf life: 24-36 months
Products Description
Overview of Xi'an Tihealth's Edotreotide Products
Xi'an Tihealth provides high-purity Edotriotide raw materials specifically tailored for the development of radiopharmaceuticals. The product has undergone solid-phase synthesis and multi-stage purification, HPLC-UV stage purification, HPLC-UV/ELSD dual validation with purity>98% and single impurity<0.1%, meeting all indicators; The inter batch difference of key indicators is less than 2%, and the endotoxin is less than 10 EU/mg, meeting the sterile requirements for nuclear drug labeling. Assist customers in efficiently promoting the industrialization of targeted diagnosis and treatment products for neuroendocrine tumors.
Products Function
1. Inhibit hormone secretion
Edotreotide is a type of somatostatin analog that can activate somatostatin receptors (mainly SSTR2 and SSTR5), inhibit the secretion of various hormones (such as growth hormone, insulin, glucagon, peptide hormones, etc.), and alleviate symptoms caused by excessive hormone release.
2. Antitumor effect
By blocking the proliferation signal of tumor cells, inducing cell apoptosis, and inhibiting tumor related angiogenesis, endorphins can delay the growth and spread of neuroendocrine tumors.
3. Regulating gastrointestinal function
Inhibit gastric acid secretion and gastrointestinal motility, and improve related digestive system symptoms.
4. Assist in radiological diagnosis and treatment
Edotreotide can be labeled with radioactive isotopes for targeted imaging of neuroendocrine tumors, helping to locate and evaluate lesions, and can also be used for radionuclide therapy.
Products Aplication
1. Diagnosis of neuroendocrine tumors
Using radiolabeled endorphins for in vivo imaging (such as SPECT scanning) to accurately locate tumors and metastases expressing somatostatin receptors.
2. Treatment of neuroendocrine tumors
Used to treat secretory neuroendocrine tumors, by inhibiting the secretion of tumor hormones, relieving symptoms of excessive hormones such as carcinoid syndrome, and delaying tumor growth.
3. Adjuvant therapy for hormone related diseases
Tumors such as pituitary growth hormone tumors (acromegaly), insulinomas, gastrinomas, etc. can benefit from the hormone inhibitory effect of endorphins.
4. Other potential applications
In the research of certain gastrointestinal disorders or hormone related diseases, there are also application explorations.
Mechanism of action
Edotreotide belongs to the class of somatostatin analogs, which can bind and activate somatostatin receptors (mainly SSTR2 and SSTR5 subtypes) in the body with high affinity. The mechanism includes:
1. Inhibiting hormone secretion: By activating somatostatin receptors, inhibiting the release of peptide hormones such as growth hormone, insulin, glucagon, etc.
2. Anti proliferative effect: Inhibits the proliferation of tumor cells by inducing apoptosis and blocking the cell cycle.
3. Inhibiting angiogenesis: reducing angiogenesis in the tumor microenvironment and limiting tumor growth.
4. Radiolabeled endorphins bind to somatostatin receptors on tumor cells to achieve targeted radiation therapy for imaging diagnosis or radiation therapy.
Pharmacological effects
● Endocrine regulation:
Inhibits the secretion of multiple hormones and alleviates related symptoms (such as symptoms caused by excessive release of serotonin in carcinoid syndrome).
● Antitumor effect:
Delaying the progression of neuroendocrine tumors and reducing tumor volume growth.
● Hemodynamic effects:
Transient constriction of visceral blood vessels, affecting local blood flow.
● Digestive system:
Inhibits gastric acid secretion and gastrointestinal motility, alleviates related symptoms.
Toxicological effects
● Endocrine regulation:
Inhibits the secretion of multiple hormones and alleviates related symptoms (such as symptoms caused by excessive release of serotonin in carcinoid syndrome).
● Antitumor effect:
Delaying the progression of neuroendocrine tumors and reducing tumor volume growth.
● Hemodynamic effects:
Transient constriction of visceral blood vessels, affecting local blood flow.
● Digestive system:
Inhibits gastric acid secretion and gastrointestinal motility, alleviates related symptoms.
Toxicological effects
Edotriotide is generally well tolerated, but the following adverse reactions may occur:
Local reaction: Pain and redness at the injection site.
Gastrointestinal reactions: nausea, diarrhea, constipation, abdominal pain.
Gallbladder related: Decreased gallbladder function, occasional formation of gallstones.
Metabolic effects: May cause abnormal blood sugar levels (hyperglycemia or hypoglycemia).
Cardiovascular system: may lead to slowed heart rate (bradycardia).
Other: In long-term use, there may be a decrease in the absorption of vitamin B12.
Toxicological studies have shown that Edotriotide has no significant organ toxicity within the recommended dosage range, but monitoring of relevant indicators is necessary for high-dose or long-term use.
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