Palmitoyl Pentapeptide-3
Plant source: synthetic
Content specification: ≥ 98%
CAS NO：214047-00-4
Testing method: HPLC
Active ingredients: Palmitic acid pentapeptide-3, a combination of palmitic acid and pentapeptide Lys Thr Thr Lys Ser.
Product mesh: 80-100 mesh
Product Description: White to off white fine powder, odorless.
Product usage: In the field of cosmetics and pharmaceutical research.
Product packaging: Aluminum foil bags/aluminum cans (1kg/bag, 5kg/can), or packaged according to customer requirements.
Product solution: Glass or plastic bottles (100ml, 500ml, etc.).
Product storage: After sealing, store in a cool and dry place, away from light
Shelf life: 24 months (powder, unopened)； 1 year (solution under refrigeration conditions).
Palmitoyl Pentapeptide-3 API Powder
CAS 214047-00-4 | High-Purity Matrikine-Mimetic Peptide | Cosmetic Grade
⚠️ REGULATORY COMPLIANCE & B2B FORMULATION: This active peptide ingredient is strictly supplied as a bulk raw material for B2B commercial cosmetic manufacturing and dermatological R&D. It is NOT intended for direct consumer application. Xi'an Tihealth guarantees sequence fidelity and analytical purity under strict ISO-aligned quality frameworks.
Product Characterization & Value Proposition
Palmitoyl Pentapeptide-3 (also known in earlier literature as Palmitoyl Pentapeptide-4, commonly referenced as Matrixyl) is a highly specific, lipophilically modified biomimetic peptide. It functions as a matrikine-a messenger peptide that mimics the active fragments of procollagen type I, stimulating dermal fibroblasts to reconstruct the extracellular matrix (ECM).
Synthesized via precision Solid-Phase Peptide Synthesis (SPPS) at Xi'an Tihealth Biotechnology Co., Ltd., our Palmitoyl Pentapeptide-3 API achieves an HPLC-validated purity of ≥98.0%. By conjugating the pentapeptide sequence (KTTKS) with a palmitic acid moiety, we ensure exceptional stratum corneum permeability, making it a gold-standard raw material for premium anti-wrinkle serums and intensive dermal repair creams.
Technical Specification (TDS Profile)
| Analytical Parameter | Tihealth Specification Limits |
|---|---|
| Sequence | Pal-Lys-Thr-Thr-Lys-Ser-OH (Pal-KTTKS) |
| CAS Registry Number | 214047-00-4 |
| Molecular Formula / Weight | C₃₉H₇₅N₇O₁₀ / 802.05 g/mol |
| Assay (HPLC, Purity) | ≥ 98.0% |
| Water Content (Karl Fischer) | ≤ 8.0% |
| Appearance | White to off-white lyophilized powder |
* Supplied in moisture-proof aluminum foil bags (1kg/5kg) or bulk cardboard drums (25kg). Lot-specific COA, MS, and HPLC chromatograms are included with all commercial shipments.
Molecular Mechanism & Formulation Dynamics
By acting as an endogenous biological signal, Palmitoyl Pentapeptide-3 activates a cascade of regenerative processes in aging cutaneous tissues:
- ECM Resynthesis: Directly stimulates dermal fibroblasts to synthesize essential structural proteins, specifically Type I, III, and IV collagen, as well as elastin and fibronectin, visibly reducing the depth and volume of dynamic wrinkles.
- DEJ Fortification: Rebuilds the Dermal-Epidermal Junction (DEJ) architecture, enhancing mechanical skin support and improving overall cutaneous laxity.
- Glycosaminoglycan (GAG) Upregulation: Promotes the endogenous production of hyaluronic acid, actively restoring dermal moisture retention capabilities and strengthening the epidermal barrier against exogenous stressors.
Cosmetic Formulation Applications
- Premium Anti-Aging Skincare: The core active for intensive wrinkle-reduction creams, eye contour treatments, and firming serums. Clinically observed to offer retinoid-like anti-aging efficacy without associated desquamation or irritation.
- Barrier Repair Solutions: Highly effective in post-UV damage recovery formulations, acting synergistically with ceramides and hyaluronic acid to restore structural integrity.
- Synergistic Formulations: Demonstrates excellent stability when compounded with Vitamin C derivatives or Pro-Xylane, targeting multiple senescence pathways simultaneously.
Technical Support & Formulation FAQ
What is the recommended inclusion rate for cosmetic formulations?
For clinically visible anti-wrinkle efficacy, the typical inclusion rate is between 3% to 8% when using a standard 100ppm aqueous solution. If formulating directly from our high-purity API powder, parts-per-million (ppm) level calculations should be applied based on the final target concentration.
How does Palmitoyl Pentapeptide-3 compare to Retinol in stability and safety?
Unlike Retinol, which operates via nuclear receptors and often causes epidermal thinning, erythema, and photosensitivity, Palmitoyl Pentapeptide-3 acts directly on fibroblasts without accelerating exfoliation. It possesses an excellent dermatological tolerability profile, making it highly suitable for sensitive skin, daytime formulations, and continuous long-term use.
What are the critical handling guidelines during compounding?
Due to its peptidic structure, it is recommended to add the API to the formulation during the final cool-down phase (typically below 40°C) to prevent thermal degradation. The palmitoyl modification provides excellent lipophilicity, facilitating seamless integration into emulsions and serums.
Accelerate Your Premium Cosmetic Formulation R&D
Contact our technical sales director for custom purity grading, bulk OEM pricing, and full analytical dossiers (COA/MSDS).
👤 Technical Director: Wang Xueyan
📧 peter@xatihealth.com 📞 WhatsApp: +86 13991246876
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