Plecanatide Powder Cas No.467426-54-6
English nickname: Trulance; Plectide
Content specification: ≥ 98%
CAS NO：467426-54-6
Detection method: HPLC
Active ingredient: Pucanapeptide (a cyclic peptide composed of 16 amino acids)
Chemical formula: C ₆₅ H ₁₀₄ N ₁₈ O ₂₆ S ₄
Molecular weight: 1681.89 g/mol
Product Description: White to off white solid
Product Usage: CIC; IBS-C
Product packaging: 1G/Bottle, 10G/Bottle,50G/Bottle or at customers reqirement.
Product storage: 20 ° C-25 ° C (room temperature), allowing short-term fluctuations up to 15 ° C-30 ° C
Shelf life: Powder: Sealed storage at -20 ° C (1 year); -80 ° C (2 years)
Products Description
Plecanatide Powder with high purity from Tihealth
Xi'an Tihealth Biotechnology specializes in providing high-purity Plecanatide raw materials, with a stable purity of ≥ 98% (verified by HPLC), in compliance with USP/EP pharmacopoeia standards. The product adopts solid-phase fragment synthesis technology and undergoes strict quality control (HPLC, mass spectrometry, and disulfide bond orientation analysis) to ensure structural consistency (CAS 467426-54-6) and low endotoxin (<0.1 IU/mg). Flexible customization of specifications (10mg-1g) can meet the needs of drug development, formulation production, and clinical research. Raw materials are packaged in sealed and light resistant packaging (frozen at -20 ℃).
As the core active ingredient of constipation treatment drugs (CIC/IBS-C), this product enhances intestinal fluid secretion by targeting the activation of GC-C receptors. Its extremely low bioavailability can significantly reduce the risk of systemic side effects. We support the development of new drugs for intestinal health with pharmaceutical grade quality. We welcome inquiries for cooperation.
Products Benefits
1,Increase intestinal fluid, soften feces, and accelerate intestinal transport
2,Partially inactivate in acidic environments, reduce colon hyperstimulation, and significantly lower the risk of diarrhea.
Products Aplication
1/Formulation production,
2/New drug development,
3/Clinical research,
4/Diagnostic reagents
Product advantages
A strict quality control system can ensure high purity of quality and extremely low impurity control.
Mechanism of action
Plecanatide and its active metabolites bind to GC-C enzyme and act locally on the luminal surface of intestinal epithelial cells. The activation of GC-C enzyme increases the concentration of cyclic guanosine monophosphate (cGMP) both inside and outside the cell, while the increase in intracellular cGMP concentration is mainly achieved through the activation of ion channels of cystic fibrosis transmembrane regulator (CFTR), which stimulates the secretion of chloride and bicarbonate into the intestinal lumen, increasing and accelerating the passage of small intestinal fluid.
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