Glucagon Powder Cas No.16941-32-5
Source: Derived from multiple species including porcine, human, and bovine.
Specification: ≥99%
CAS No.: 16941-32-5
Molecular Formula: C₁₅₃H₂₂₅N₄₃O₄₉S
Molecular Weight: 3482.8
Test Method: HPLC
Active Ingredient: Glucagon
Product Characteristics: White or off-white lyophilized powder.
Packaging: Various specifications available (from mg to kg), customizable.
Storage Condition: Store sealed and protected from light at 2-8°C.
Shelf Life: 36 months
Declaration of Use: This product is intended for industrial use or scientific research only.
Glucagon API Powder
Pharmaceutical-Grade 29-Amino-Acid Peptide | Hyperglycemic Agent
⚠️ REGULATORY COMPLIANCE & RESEARCH USE ONLY (RUO): This high-purity Glucagon is supplied strictly as a raw material API powder for professional laboratory research, biopharmaceutical formulation development, and comparative metabolic studies. It is explicitly prohibited for direct administration to humans or animals.
🔬 Absolute Sequence Fidelity
Synthetic pathways rigorously validated by ESI-MS, guaranteeing the exact 29-amino-acid structure and the complete absence of truncated impurities.
📑 Global CMC Support
Full technical dossier provisions including precise HPLC chromatograms, mass spectrometry profiles, and stability data to accelerate global regulatory filings.
🧪 Formulation Stability Matrix
Supplied as a highly stable, low-moisture lyophilized powder at -20°C, offering expert technical guidance for overcoming liquid formulation gelation challenges.
Product Characterization
Glucagon is a highly conserved 29-amino-acid polypeptide hormone acting as the primary counter-regulatory mechanism to insulin. It engages specifically with the Glucagon Receptor (GCGR), a G-protein-coupled receptor, initiating rapid intracellular responses primarily within the hepatic and gastrointestinal systems.
Xi'an Tihealth Biotechnology Co., Ltd. supplies this vital active pharmaceutical ingredient (API) with a strictly validated HPLC purity of ≥ 99.0%. Manufactured under stringent ISO9001:2015 conditions, our synthetic Glucagon is optimized to support the rigorous demands of emergency hypoglycemia rescue formulations, gastrointestinal diagnostic agents, and cutting-edge metabolic dual-agonist research.
Technical Specification (TDS Profile)
| Analytical Parameter | Tihealth Specification Limits |
|---|---|
| Generic Name | Glucagon (Synthetic / 29-Amino-Acid Peptide) |
| CAS Registry Number | 16941-32-5 |
| Molecular Formula | C153H225N43O49S |
| Molecular Weight | 3482.8 g/mol |
| Assay (HPLC Purity) | ≥ 99.0% (No truncation impurities) |
| Appearance | White to off-white lyophilized powder |
Storage & Formulation Protocols: Store strictly at -20°C in a desiccated environment. Glucagon is highly prone to amyloid-like fibrillation and gelation in neutral aqueous solutions. For liquid formulation research, strict pH control (typically highly acidic, pH 2.0-3.0) or the use of specific aprotic solvents/excipients is mandatory to maintain peptide integrity.
Pharmacodynamics & GCGR Interaction
- Hepatic Glucose Output: Receptor binding activates adenylate cyclase, resulting in a surge of intracellular cAMP. This robustly stimulates glycogenolysis and gluconeogenesis, rapidly elevating blood glucose levels.
- GI Spasmolytic Effect: Exerts a potent relaxing effect on the smooth muscles of the stomach, duodenum, and colon, independent of cholinergic blockade.
- Lipid Metabolism: Plays a regulatory role in hepatic lipid metabolism and beta-oxidation.
Diagnostic & R&D Applications
- Severe Hypoglycemia Rescue: Core API for emergency lyophilized rescue kits, auto-injectors, and intranasal dry-powder delivery systems.
- Diagnostic Imaging Aids: Formulated as a spasmolytic agent to temporarily inhibit GI motility during radiological and MRI examinations.
- Metabolic Dual-Agonist Research: Essential reference standard in the explosive R&D field of GLP-1/Glucagon receptor co-agonists targeting obesity and NASH.
API Procurement & Technical FAQ
How does your API address the fibrillation/gelation challenges of Glucagon?
Fibrillation in neutral aqueous solutions is an inherent biophysical property of the 29-amino-acid sequence. Our API is supplied as a highly stable, low-moisture lyophilized powder to guarantee shelf-life prior to reconstitution. For liquid stable formulations, your R&D team must employ acidic environments (pH < 3.0) or utilize novel stabilization matrices.
How is the sequence fidelity of this synthetic 29-amino-acid peptide verified?
Sequence accuracy is critical. Every batch is validated not only by HPLC for absolute purity (≥ 99.0%) but also undergoes rigorous Electrospray Ionization Mass Spectrometry (ESI-MS) to confirm the exact molecular weight (3482.8 Da) and ensure the complete absence of truncated peptide impurities.
Can this API be utilized as a baseline control in GLP-1/Glucagon co-agonist trials?
Yes. Its exceptionally high purity and precise synthetic profile make it an ideal reference standard or baseline comparator compound for in-vitro binding assays and in-vivo metabolic studies evaluating novel dual-receptor or tri-receptor agonists.
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