Glucagon Powder Cas No.16941-32-5
Source: Derived from multiple species including porcine, human, and bovine.
Specification: ≥99%
CAS No.: 16941-32-5
Molecular Formula: C₁₅₃H₂₂₅N₄₃O₄₉S
Molecular Weight: 3482.8
Test Method: HPLC
Active Ingredient: Glucagon
Product Characteristics: White or off-white lyophilized powder.
Packaging: Various specifications available (from mg to kg), customizable.
Storage Condition: Store sealed and protected from light at 2-8°C.
Shelf Life: 36 months
Declaration of Use: This product is intended for industrial use or scientific research only.
Glucagon API Powder | CAS 16941-32-5 | Hyperglycemic Agent
Glucagon is a highly conserved 29-amino-acid polypeptide hormone acting as the primary counter-regulatory mechanism to insulin. Xi'an Tihealth Biotechnology Co., Ltd. supplies this vital active pharmaceutical ingredient (API) with a strictly validated HPLC purity of ≥ 99.0%. Manufactured under stringent ISO9001:2015 conditions, our synthetic Glucagon guarantees absolute sequence fidelity. It is optimized to support the rigorous demands of emergency hypoglycemia rescue formulations, gastrointestinal diagnostic agents, and cutting-edge metabolic dual-agonist research.
⚠️ REGULATORY COMPLIANCE & STRICT RESEARCH USE ONLY (RUO)
Industrial R&D Application: This high-purity Glucagon is supplied strictly as a raw material API powder for professional laboratory research, biopharmaceutical formulation development, and comparative metabolic studies. It is NOT a finished pharmaceutical drug and is explicitly prohibited for direct administration to humans or animals.
Chemical Profile & Specification Parameters
| Analytical Parameter | Xi'an Tihealth Specification |
|---|---|
| Generic Name | Glucagon (Synthetic / 29-Amino-Acid Peptide) |
| CAS Number | 16941-32-5 |
| Molecular Formula | C153H225N43O49S |
| Molecular Weight | 3482.8 g/mol |
| Peptide Purity (HPLC) | ≥ 99.0% (No truncation impurities) |
| Appearance | White to off-white lyophilized powder |
Storage & Formulation Protocols: Store strictly at -20°C in a desiccated environment. Glucagon is highly prone to amyloid-like fibrillation and gelation in neutral aqueous solutions. For liquid formulation research, strict pH control (typically highly acidic, pH 2.0-3.0) or the use of specific aprotic solvents/excipients is mandatory to maintain peptide integrity.
Pharmacodynamics & Receptor Interaction
Glucagon engages specifically with the Glucagon Receptor (GCGR), a G-protein-coupled receptor, initiating rapid intracellular responses primarily within the hepatic and gastrointestinal systems:
- Hepatic Glucose Output: Receptor binding activates adenylate cyclase, resulting in a surge of intracellular cyclic AMP (cAMP). This robustly stimulates glycogenolysis (breakdown of stored glycogen) and gluconeogenesis, rapidly elevating blood glucose levels.
- Gastrointestinal Spasmolytic Effect: Beyond its metabolic role, Glucagon exerts a potent relaxing effect on the smooth muscles of the stomach, duodenum, and colon, independent of cholinergic blockade.
- Lipid Metabolism: Plays a regulatory role in hepatic lipid metabolism and beta-oxidation, a mechanism heavily investigated in modern metabolic syndrome treatments.
Therapeutic & Diagnostic R&D Applications
Xi'an Tihealth's high-purity Glucagon API is a critical raw material for several distinct pharmaceutical development pipelines:
- Severe Hypoglycemia Rescue: Used as the core API in the formulation of emergency lyophilized rescue kits, auto-injectors, and next-generation intranasal dry-powder delivery systems.
- Diagnostic Imaging Aids: Formulated as a spasmolytic agent to temporarily inhibit gastrointestinal motility during radiological, endoscopic, and MRI examinations of the GI tract.
- Metabolic Dual-Agonist Research: Serves as an essential reference standard and baseline compound in the explosive R&D field of GLP-1/Glucagon receptor co-agonists (targeting obesity and MASH/NASH).
API Procurement & Formulation FAQ
Fibrillation in neutral aqueous solutions is an inherent biophysical property of the 29-amino-acid sequence. Our API is supplied as a highly stable, low-moisture lyophilized powder to guarantee shelf-life prior to reconstitution. For liquid stable formulations, your R&D team must employ acidic environments (pH < 3.0) or utilize novel stabilization matrices.
Sequence accuracy is critical. Every batch is validated not only by HPLC for absolute purity (≥ 99.0%) but also undergoes rigorous Electrospray Ionization Mass Spectrometry (ESI-MS) to confirm the exact molecular weight (3482.8 Da) and ensure the complete absence of truncated peptide impurities.
Yes. Its exceptionally high purity and precise synthetic profile make it an ideal reference standard or baseline comparator compound for in-vitro binding assays and in-vivo metabolic studies evaluating novel dual-receptor or tri-receptor agonists.
Xi'an Tihealth Biotechnology Co., Ltd. Quality Commitment: GMP-aligned pharmaceutical API intended strictly for laboratory analysis and formulation R&D. Not for direct clinical administration.
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