Vitamin A Powder Retinol Cas No.68-26-8
Source: Synthetic
Purity: ≥99%
CAS No.: 68-26-8
Molecular Formula: C₂₀H₃₀O
Molecular Weight: 286.45 g/mol
Testing Method: HPLC
Active Ingredient: All-trans Retinol
Appearance: Yellow to orange-yellow fine crystalline powder
Packaging: 1 kg/aluminum foil bag; 25 kg/drum
Storage: Store in a dry, ventilated place, protected from light, and sealed at room temperature
Shelf Life: 24 months
Declaration of Use: This product is intended for industrial use or scientific research only.
All-trans-Retinol API Powder (Vitamin A Alcohol)
CAS 68-26-8 | Pharmaceutical & Dermo-Cosmetic Grade | Stereoisomeric Purity ≥ 99.0%
⚠️ REGULATORY COMPLIANCE & SAFETY WARNING: High-purity All-trans-Retinol (Vitamin A) API possesses high biological activity and potential teratogenicity at elevated industrial dosages. This product is strictly supplied as a bulk active substance for B2B industrial formulation, dermo-cosmetic compounding, and laboratory R&D. Downstream manufacturers are solely responsible for verifying compliance with regional FDA/EMA/Cosmetic Directives regarding maximum allowable finished concentrations.
Product Characterization & Stereoisomeric Purity
Retinol (Vitamin A alcohol, CAS No. 68-26-8) is a core fat-soluble vitamin and a highly potent active pharmaceutical ingredient. Because the molecular structure of Retinol features a highly conjugated polyene chain, it is highly susceptible to photo-induced cis-trans isomerization, which dramatically diminishes biological efficacy.
As a premier global supplier of dermatological actives, Xi'an Tihealth Biotechnology Co., Ltd. specializes in the synthesis and precise refinement of **All-trans-Retinol powder**. Our cGMP-aligned isolation protocols strictly control and stabilize the all-trans configuration to ≥99.0% (validated by RP-HPLC). This ensures the ultimate biological affinity and consistent gene-transcription activation required for professional anti-aging formulations, acne-targeted pharmaceuticals, and clinical-grade dermo-cosmetics.
Technical Data Sheet (TDS Profile)
| Analytical Parameter | Tihealth Specification Limits (Pharma Grade) |
|---|---|
| Chemical Name | (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol |
| CAS Registry Number | 68-26-8 |
| Assay (HPLC, All-trans isomer) | ≥ 99.0% |
| Appearance | Pale yellow to yellow crystalline powder |
| Solubility Profile | Practically insoluble in water; freely soluble in absolute ethanol, ether, and lipophilic triglyceride carriers |
| Molecular Sensitivity | Extremely unstable; highly sensitive to atmospheric oxygen, light/UV radiation, and high thermal profiles |
* Batch-specific quality assurance dossiers-including nuclear magnetic resonance (NMR), mass spectrometry (MS) reports, and heavy metal tracking-are bundled with each shipment.
Molecular Mechanism & Formulation Applications
The pharmacological efficacy of All-trans-Retinol is dictated by its endogenous metabolic conversion and subsequent nuclear receptor binding kinetics:
- Metabolic Oxidation Cascade: Upon cutaneous absorption, pure Retinol is enzymatically oxidized into Retinaldehyde (Retinal), which is further metabolized into the ultimate active ligand, Retinoic Acid (Tretinoin).
- Nuclear Receptor Translocation (RAR/RXR): Retinoic acid translocates into the nucleus, activating Retinoic Acid Receptors (RAR) and Retinoid X Receptors (RXR). This dimerization alters target gene transcription related to cellular turnover.
- Extracellular Matrix (ECM) Overhaul: This pathway stimulates epidermal keratinocyte proliferation, accelerates the shedding of microcomedones (acne intervention), and aggressively upregulates Type I and Type III Collagen synthesis within the dermis.
Industrial & Pharmaceutical Applications
- Dermatological Prescription APIs: The core active agent utilized in targeted clinical ointments for treating acne vulgaris, psoriasis, and severe hyper-keratinization disorders.
- Advanced Dermo-Cosmetic Systems: The gold-standard ingredient for clinical anti-wrinkle serums, night repair creams, and intensive hyperpigmentation correction complexes.
- Dietary Fortification & Nutrition: A critical raw material for advanced nutritional formulations designed to maintain scotopic vision (rhodopsin synthesis) and systemic immunological responses.
Technical Support & Formulation FAQ
How does Xi'an Tihealth ensure the molecular stability of ≥99.0% pure Retinol powder?
Pure All-trans-Retinol is highly susceptible to oxidative and thermal degradation. We utilize advanced B2B protective packaging, sealing the active crystalline powder under a pressurized inert gas (Nitrogen/Argon) atmosphere within light-proof, heavy-duty aluminum containers. Unopened, this configuration preserves active potency for up to 24 months under recommended storage profiles.
What are the critical handling guidelines for cosmetic formulators?
During manufacturing, All-trans-Retinol must be handled strictly under yellow light conditions to prevent UV-induced isomerization. It should be added to the lipophilic phase during the cool-down stage (<40°C). Formulators are strongly advised to incorporate synergistic antioxidants-such as BHT, BHA, or Tocopherol-into the oil phase to secure the active molecule in the final emulsion.
What is the biochemical distinction between pure Retinol and Retinyl Palmitate?
Retinol is the pure active alcohol form, offering substantially higher biological activity and immediate pathway conversion. Retinyl Palmitate is a pre-esterified derivative; although it exhibits superior chemical stability against ambient oxidation, it is biologically weaker and requires an extra, slow enzymatic cleavage step within the skin before it can binding to nuclear receptors.
Empower Your Dermatological R&D With Premium APIs
Contact our technical sales director for custom purity options, inert packaging details, and full analytical validation (COA/MSDS).
👤 Technical Director: Wang Xueyan
📧 peter@xatihealth.com 📞 WhatsApp: +86 13991246876
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