High-Purity All-trans-Retinol API Powder | CAS 68-26-8

Retinol (Vitamin A alcohol, CAS No. 68-26-8) is a foundational fat-soluble vitamin and a highly potent active pharmaceutical ingredient (API). Xi'an Tihealth specializes in the synthesis and refinement of pharmaceutical-grade All-trans-Retinol powder, guaranteeing an HPLC-validated purity of ≥99.0%. As the most biologically active form of Vitamin A available for topical and systemic formulation, our Retinol API is strictly manufactured under cGMP guidelines. It serves as the gold-standard core ingredient for dermatological prescription drugs, advanced anti-aging dermo-cosmetics, and specialized nutritional fortifiers, delivering unparalleled cellular turnover and collagen-stimulating efficacy.

Due to the inherent molecular sensitivity of highly conjugated double bonds, Xi'an Tihealth implements rigorous quality control and inert-gas packaging to ensure absolute structural integrity upon delivery.

The pharmacological and cosmetic efficacy of Retinol is dictated by its endogenous metabolic conversion and subsequent nuclear receptor binding:

• Metabolic Conversion Pathway: Upon topical application or systemic absorption, pure Retinol is enzymatically oxidized into Retinaldehyde (Retinal), which is further oxidized into the ultimate active ligand, Retinoic Acid (Tretinoin).
• Gene Expression Transcription (RAR/RXR): Retinoic acid translocates into the cell nucleus, binding to and activating Retinoic Acid Receptors (RAR) and Retinoid X Receptors (RXR). This dimerization alters the transcription of multiple target genes related to tissue development.
• Extracellular Matrix (ECM) Remodeling: In dermatology, this pathway aggressively stimulates the proliferation of epidermal keratinocytes, accelerates the shedding of comedones (acne treatment), and upregulates the synthesis of Type I and Type III collagen within the dermis (anti-aging).

• Dermatological APIs: Utilized in the formulation of prescription ointments and gels for treating acne vulgaris, psoriasis, and severe keratinization disorders.
• Advanced Dermo-Cosmetics: The undisputed core ingredient for high-performance anti-aging serums and night creams, clinically proven to reduce fine lines, normalize pigmentation, and refine skin texture.
• Dietary Fortification: Acts as a crucial supplement for synthesizing rhodopsin (maintaining scotopic vision) and supporting systemic immune functions.

Pure All-trans-Retinol is highly susceptible to oxidation. We utilize advanced packaging technology, sealing the API under a strict inert gas (Nitrogen/Argon) atmosphere in specialized light-proof aluminum containers. Unopened, this ensures up to 24 months of shelf life under controlled storage conditions.

2,What are the handling recommendations for cosmetic formulators?

During formulation, pure Retinol must be handled under yellow light (to prevent UV degradation) and added to the lipophilic phase during the cool-down stage (<40°C). Formulators are strongly advised to incorporate antioxidants (such as BHT, BHA, or Vitamin E) into the formulation to protect the active ingredient.

3,What is the difference between pure Retinol and Retinyl Palmitate?

Retinol is the pure alcohol form, offering significantly higher biological activity and faster conversion to retinoic acid. Retinyl Palmitate is an ester derivative; while much more stable against oxidation, it is biologically weaker and requires an extra enzymatic cleavage step in the skin before it becomes active.