Magnesium Hydroxide API Powder CAS 1309-42-8

Magnesium Hydroxide API Powder CAS 1309-42-8

Product Name: Magnesium Hydroxide Powder
Source: Synthetic
Purity: ≥98.5%
CAS No.: 1309-42-8
Molecular Formula: Mg(OH)₂
Molecular Weight: 58.32
Active Ingredient: Magnesium Hydroxide (Mg(OH)₂)
Appearance: White odorless powder or crystals
Packaging: 25 kg/bag
Storage: Store in a dry, cool, and well-ventilated place
Shelf Life: 24 months

Declaration of Use: This product is intended for industrial use or scientific research only.
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Magnesium Hydroxide API Powder CAS 1309-42-8

Why Is Precise Bulk Density Critical For Antacid Formulations?

CAS Number: 1309-42-8
Molecular Formula: Mg(OH)2
Molecular Weight: 58.32 g/mol
Assay Standard: ≥ 98.5% (USP/EP)

1. API Characterization & Manufacturing Value

Xi'an Tihealth manufactures pharmaceutical-grade Magnesium Hydroxide API (CAS 1309-42-8), a foundational inorganic compound utilized globally as a rapid-acting antacid and osmotic laxative agent. Synthesized under stringent cGMP-compliant conditions, our highly purified powder offers exceptional acid-neutralizing capacity and serves as an indispensable active ingredient and functional excipient for gastrointestinal therapeutic formulations.

We understand that physical parameters dictate manufacturing success. Therefore, we supply strictly controlled specific grades: "Light" Magnesium Hydroxide (optimized with a high specific surface area to prevent rapid sedimentation in liquid suspensions) and "Heavy" Magnesium Hydroxide (engineered with a higher bulk density for superior flowability in direct-compression tableting). Both grades maintain rigorous compliance with elemental impurity limits (ICH Q3D), ensuring an absence of toxic heavy metals typically found in natural brucite mineral extracts.

2. Technical Data Sheet (TDS) & Specifications

Quality Parameter Specification Limit (USP / EP)
Physical Appearance White, bulky, odorless crystalline powder
Assay (Dried Basis) 98.5% – 100.5%
Bulk Density Profiling Customized "Light" or "Heavy" grades per formulation needs
Loss on Ignition 30.0% – 32.5%
Soluble Salts ≤ 2.0%
Heavy Metals (Pb, As) ≤ 20 ppm (Strict elemental impurity control)
Microbial Limits Absence of E. coli and Salmonella

3. Pharmacodynamics & Gastrointestinal Mechanisms

Rapid Acid Neutralization

Operating locally within the stomach, Magnesium Hydroxide acts as a potent inorganic antacid. It reacts chemically with gastric hydrochloric acid (HCl) to form magnesium chloride and water, rapidly elevating gastric pH and effectively mitigating mucosal irritation associated with hyperacidity and peptic ulcers.

Osmotic Laxative Dynamics

Because magnesium ions are poorly absorbed by the intestinal tract, they exert a powerful osmotic gradient in the small intestine. This retains water within the intraluminal space, increasing volume, stimulating mechanoreceptors, and promoting peristalsis for reliable bowel evacuation.

4. Core Pharmaceutical Applications

  • Liquid Suspensions (Milk of Magnesia): The "Light" API grade is the primary ingredient utilized in formulating aqueous antacid and laxative suspensions, engineered for minimal sedimentation and rapid re-suspendability.
  • Solid Oral Dosages: The "Heavy" API grade is widely compounded into direct-compression chewable antacid tablets, frequently co-formulated with Aluminum Hydroxide to balance bowel motility effects.
  • Pharmaceutical Excipient Functionality: Deployed as a highly effective alkaline pH modifier and stabilizing agent in the formulation matrices of acid-sensitive active pharmaceutical ingredients.
B2B SOURCING & REGULATORY DIRECTIVE

This active pharmaceutical ingredient (API) is supplied exclusively as a bulk raw material for B2B industrial pharmaceutical compounding, commercial formulation development, and authorized laboratory R&D. It is not intended for direct consumer administration. Xi'an Tihealth provides full chemical analysis, particle size distribution data, and trace-metal validation to support global pharmacopeial registration (DMF available).

5. Frequently Asked Technical Questions

How do you differentiate between Light and Heavy Magnesium Hydroxide grades?
The difference lies in the bulk density and particle size distribution (PSD), controlled during our precipitation process. The "Light" grade has a lower bulk density and higher specific surface area, making it ideal for liquid suspensions to prevent rapid settling. The "Heavy" grade has a higher bulk density, providing the superior flowability necessary for high-speed direct compression in tablet manufacturing.
Does this API comply with stringent heavy metal limits?
Absolutely. Unlike Magnesium Hydroxide derived directly from crushed natural brucite (which often contains high levels of lead, arsenic, and iron), our synthetic precipitation process utilizes highly purified starting materials. This ensures that elemental impurities strictly adhere to the rigorous ICH Q3D limits and USP/EP monographs.
What is the standard commercial packaging for bulk orders?
Our standard industrial packaging consists of 25kg multi-wall paper bags fitted with double inner polyethylene (PE) liners to rigorously prevent moisture absorption during transit. We also accommodate customized 1kg to 5kg packaging for laboratory R&D, pilot-scale trials, and stability testing.
 

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