Delafloxacin Meglumine Powder Cas No.352458-37-8
Product Origin: Synthetic
Product Specification: ≥98%
CAS No.: 352458-37-8
Molecular Formula: C₂₅H₂₉ClF₃N₅O₉
Molecular Weight: 635.98
Test Method: HPLC
Active Ingredient: Delafloxacin Meglumine
Product Characteristics: Off-white to yellow powder
Product Packaging: 1kg/bag; 25kg/drum
Storage Conditions: Store at 2-8°C in an inert gas environment
Shelf Life: 24 months
Declaration of Use: This product is intended for industrial use or scientific research only.
What is Delafloxacin Meglumine API?
High-Purity Delafloxacin Meglumine API | CAS 352458-37-8
Delafloxacin Meglumine (CAS No. 352458-37-8) is a synthetic, broad-spectrum anionic fluoroquinolone antibiotic. Unlike traditional quinolones, its unique molecular structure lacks a basic group at the C7 position, granting it superior potency against Gram-positive pathogens, including MRSA. Manufactured under stringent cGMP-compliant protocols, Xi'an Tihealth supplies pharmaceutical-grade Delafloxacin Meglumine powder with an HPLC-validated purity of ≥98.0%. This API is specifically engineered for manufacturers of intravenous and oral solid dosages, offering a dual-targeting mechanism and exceptional stability in acidic infection environments, making it a critical asset in the treatment of ABSSSI and CABP.
What are the core technical specifications?
| Parameter | Product Specification |
|---|---|
| Chemical Name | 1-deoxy-1-(methylamino)-D-glucitol 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate |
| CAS Number | 352458-37-8 |
| Molecular Formula |
C25H29ClF3N5O9 |
| Molecular Weight | 635.98 g/mol |
| Assay (HPLC, Dried Basis) | ≥ 98.0% |
| Appearance | Off-white to yellow crystalline powder |
| Storage Conditions | Store at 2-8°C under inert gas (Nitrogen/Argon) |
What is the bactericidal mechanism of action?
Delafloxacin Meglumine exhibits a unique pharmacodynamic profile compared to earlier fluoroquinolones:
- Balanced Dual Targeting: It exerts its bactericidal effect by equipotently inhibiting both bacterial DNA gyrase and topoisomerase IV. This balanced affinity significantly reduces the likelihood of selection for resistant strains, particularly in Gram-positive bacteria.
- Anionic Molecular Advantage: The anionic nature of Delafloxacin facilitates increased intracellular accumulation in acidic environments (pH 5.5). While other quinolones lose potency at lower pH, Delafloxacin's MIC actually decreases, making it exceptionally effective at the site of inflammatory infections.
- Broad-Spectrum Eradication: Effective against a wide array of pathogens, including Methicillin-resistant Staphylococcus aureus (MRSA), Gram-negative anaerobes, and fluoroquinolone-resistant strains.
What are the primary pharmaceutical applications?
- ABSSSI Formulations: The primary Active Pharmaceutical Ingredient for manufacturing immediate-release tablets and lyophilized powders for injection used in severe skin and skin structure infections.
- CABP Drug Development: Utilized in formulating advanced anti-infective regimens for community-acquired bacterial pneumonia.
- Research & Development: High-specification tool compound for investigating fluoroquinolone resistance kinetics and antimicrobial pharmacodynamics.
Compliance Notice: Intended strictly for industrial formulation and scientific research. Not for human or veterinary diagnostic use. Storage under inert gas at 2-8°C is mandatory to prevent oxidative degradation.
Frequently Asked Questions (FAQ)
Why is the Meglumine salt form advantageous for Delafloxacin?
The meglumine salt significantly enhances the solubility and systemic bioavailability of the Delafloxacin parent molecule. This allows for more stable and predictable pharmacokinetics in both oral and intravenous delivery systems compared to the free acid form.
How do storage conditions under inert gas impact shelf life?
Since Delafloxacin Meglumine crystalline powder can be sensitive to atmospheric moisture and oxygen, storage at 2-8°C under Nitrogen or Argon gas prevents potential oxidation and maintains the validated HPLC purity for a minimum of 24 months.
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