Crosslinked Sodium Hyaluronate
Content specification: Hyaluronic acid content: ≥ 95% (HPLC method)
Purity detection: HPLC
CAS NO: 9067-32-7
Cosmetic grade: 200-400 mesh (cream base)
Appearance: White to almost white fibrous powder;
The aqueous solution is transparent gel, pH 6.5-7.5 (1% aqueous solution);
Solid powder is stored under conditions of relative humidity ≤ 60% and temperature 15-25 ℃
Shelf life: unopened raw material powder: 24 months (microbial limit needs to be reviewed)
Crosslinked Sodium Hyaluronate Gel/Powder represents the apex of macromolecular engineering for the cosmetic and dermal aesthetic industries. Utilizing advanced chemical crosslinking technologies (typically via BDDE or DVS), Xi'an Tihealth Biotechnology Co., Ltd. transforms premium non-animal derived bacterial fermentation hyaluronan into a highly stable, three-dimensional polymeric network. As a specialized China Cosmetic Ingredients Manufacturer, we engineer this structural modification to exponentially increase tissue half-life, mechanical viscosity, and resistance to enzymatic degradation (hyaluronidase), delivering sustained hydration and scaffolding properties essential for high-end topical formulations and professional derma-care applications.
Physicochemical Profile & Technical Specifications
Our crosslinked hyaluronan portfolio is engineered under strict ISO9001:2015 controls, ensuring extremely low residual crosslinkers and unmatched biocompatibility. The following specifications outline our standard cosmetic and dermal-topical grades.
| Analytical Parameter | Xi'an Tihealth Specification Limit |
|---|---|
| Source / Origin | 100% Non-Animal (Streptococcus equi fermentation) |
| Appearance | Colorless to pale yellow viscous transparent gel / White powder |
| Crosslinking Agent Residue (e.g., BDDE) | Strictly controlled ≤ 2.0 ppm (Highly Biocompatible) |
| Protein Content | ≤ 0.1% (Minimizing hypersensitivity risks) |
| pH Value (Aqueous phase) | 6.5 - 7.5 |
| Heavy Metals (as Pb) | ≤ 10 ppm |
| Bacterial Endotoxins | < 0.5 EU/mg / < 0.05 EU/mg (Grade Dependent) |
Industrial Cosmetic & Dermatological Applications
Compared to linear uncrosslinked HA, our macromolecular crosslinked matrix functions as a "micro-reservoir," delivering a prolonged, time-released hydration effect. It is widely sourced by global cosmetic manufacturers and dermatology R&D laboratories for:
- Premium Anti-Aging Serums: Creating a breathable visco-elastic film on the epidermis that dramatically reduces Trans-Epidermal Water Loss (TEWL) while instantly smoothing fine lines.
- Intensive Repair Masks & Lotions: Enhancing the rheological properties and sensory feel of cosmetic vehicles, providing a sustained moisturizing shield.
- Topical Dermal Formulations: Supplying high-purity, low-endotoxin raw materials for professional skin-barrier repair creams utilized in post-aesthetic care.
Formulation & Supply Chain FAQ
Why is controlling free BDDE (1,4-Butanediol diglycidyl ether) critical for Crosslinked HA safety?
Can you customize the viscosity or degree of crosslinking for specific cosmetic formulations?
What are your commercial packing standards and lead times?
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