Folic Acid Powder

Folic acid powder has the following unique advantages:
1. In terms of precise dosage supplementation
Flexible and adjustable dosage
The demand for folic acid varies among different populations. For example, the recommended daily intake for preventing folate deficiency in normal adults is around 400 micrograms, while pregnant women may need 600-800 micrograms. Folic acid powder can be conveniently and accurately adjusted in dosage according to individual needs. Users can accurately measure the amount of folic acid they need using a measuring tool (such as a small milligram spoon), which is more advantageous in dosage adjustment than some fixed dose folic acid tablets.
For example, patients with special medical needs, such as those with abnormal folate metabolism due to certain diseases, may require higher doses of folate supplementation. Folic acid powder allows doctors to accurately develop a supplementation plan based on the patient's specific condition, such as the folate metabolism ability shown by genetic testing results, to avoid excessive or insufficient intake.
 

Customized supplements suitable for special populations
- For people with swallowing difficulties, such as the elderly or some patients with throat diseases, swallowing tablets may be difficult. Folic acid powder can be dissolved in liquids, making it convenient for these people to take. For example, dissolving folic acid powder in fruit juice or warm water can make it easier for them to get enough folic acid.
- Children are also a special supplementary group, and their demand for folic acid is relatively low. Folic acid powder can be precisely formulated into small doses suitable for children based on their age and weight. For example, it can be conveniently prepared into a solution containing a certain amount of micrograms of folic acid per milliliter, making it easy for children to take.
 

2. Absorption and utilization aspects
The absorption speed may be faster
- Folic acid powder exists in powder form and has a relatively large dispersion area in the gastrointestinal tract. When it enters the stomach and intestines, it can come into contact with digestive fluids more quickly, and the process of decomposition and absorption may be more rapid. In contrast, folic acid tablets need to disintegrate in the gastrointestinal tract before releasing folate components for absorption.
- For example, in experiments simulating intestinal absorption, the proportion of folic acid powder that can be absorbed by the intestine within a certain period of time (such as 30 minutes) may be a certain percentage higher than the same dose of folic acid tablets (the specific value varies depending on experimental conditions and other factors), which allows folic acid to enter the bloodstream faster and play its physiological role, such as participating in processes such as DNA synthesis and cell division.
 

Reduce interference from auxiliary materials
- Folic acid tablets usually contain some auxiliary materials during the production process, such as fillers (starch, etc.), binders (such as polyvinylpyrrolidone), and lubricants (magnesium stearate, etc.). These excipients may to some extent affect the absorption of folic acid or cause adverse reactions in certain sensitive populations. Folic acid powder is relatively pure, mainly composed of folic acid, reducing the potential interference of excipients on folic acid absorption.
- For example, for some people who are allergic to starch, taking folic acid tablets containing starch excipients may cause allergic reactions, while folic acid powder can avoid this situation and also help improve the bioavailability of folic acid.
 

The functions and applications of folic acid powder can be described in detail from multiple aspects.

1. Promote DNA synthesis and cell division:
Folic acid is an important coenzyme for DNA synthesis, involved in cell division and proliferation, and crucial for tissue growth and cell function.

2. Preventing birth defects:
Proper intake of folic acid before and during pregnancy can help prevent birth defects such as fetal neural tube defects.

3. Improving blood health:
Folic acid helps with the production of red blood cells and prevents megaloblastic anemia.

4. Lowering homocysteine levels:
High dose folate supplements can effectively reduce homocysteine levels in patients with coronary heart disease and improve vascular function.

5. Antioxidant effect:
Folic acid has shown effective free radical scavenging activity in laboratory studies, comparable to vitamins C and E.

6. Supporting the immune system:
Folic acid helps to support a healthy immune system.

 

 

The functions and applications of folic acid powder can be described in detail from multiple aspects.

Health supplements and nutritional supplements

Folic acid is often added to health foods to supplement vitamins, improve nutritional anemia, lose weight, etc.

Food fortifier

Folic acid, as a mandatory food additive, is widely used in bread, cookies, macaroni, cookies, cereal, rice and other foods to improve the overall quality of the nation.

Medical use

Used for preventing and treating metabolic disorders caused by folate deficiency, such as oral keratosis, cheilitis, glossitis, etc.

Tumor treatment

Folic acid modified drug delivery systems can be used for targeted tumor killing agents, such as folic acid modified tetrandrine chitosan nanoparticles, which have significant inhibitory effects on liver cancer cells.

Gene therapy

Folic acid preparations are used as carriers for targeted drugs in gene therapy.

Infant and maternity food

Folic acid is added to infant and toddler food, maternity formula, solid drinks, etc. to meet the nutritional needs of specific populations.

Folic acid powder has a wide range of applications in promoting health, preventing diseases, and as a nutritional supplement.

The production process of folic acid powder involves multiple steps, mainly including chemical synthesis and refining processes. The following is a detailed description of the production process:

1. Production of triaminopyrimidine sulfate:
Ring reaction section: In the drying reactor, sodium methoxide, guanidine nitrate, and methyl cyanoacetate are added, and the temperature and drip rate are controlled for reflux reaction. After the reaction is complete, distill and recover methanol, and vacuum recover the remaining methanol. Then add water to dissolve and directly put it into the nitrosation kettle.
Nitrification section: Add the cyclization solution into the reaction kettle, add water, hydrochloric acid, and sodium nitrite, adjust the pH to 6.5-7.5, and carry out nitrosation reaction until the pH is 2.3-2.7. After pressure filtration, the filter cake enters the next process for reduction.
Reduction section: In the clean reaction kettle, water, nitrosation material, and flake alkali melt are added, with a pH of 12-13. Hydrogenation is carried out to around 84 ℃, and the pressure is increased to around 0.4MPa. After hydrogenation is completed, the reactor is directly emptied.
Salting section: Filter the feed liquid from the hydrogenation kettle into the crystallization kettle, add dilute sulfuric acid, heat up to 70-80 ℃, let it stand for 15 minutes, filter and collect the catalyst, centrifuge and spin dry the material to obtain triamine for folic acid production.

2. Production of folic acid:
Ring reaction section: In the reaction kettle, water, sodium metabisulfite, p-aminobenzoic acid, triamine, and trichloroacetone aqueous solution are added, with pH controlled at 2.5, stirred for 24 hours, filtered and then loaded into barrels.
Acid refining section: Pump hydrochloric acid into the high-level tank, add ring compound, add hydrochloric acid until the material is basically dissolved, stop dripping, add activated carbon for decolorization, separate waste activated carbon and other materials, put the filtrate into the kettle, slowly add water to precipitate folic acid, obtain crude folic acid, and discharge the filtrate as wastewater.

3. Alkali refining section:
Add water and steam to the refining kettle, add crude folic acid, stir and disperse, add sodium hydroxide dropwise at around 75 ℃, stir to adjust pH 2.5~3.0, and keep at 75 ℃ for 2 hours. The material is pumped into the plate and frame filter press through the pressure pump, and the filtrate is sent to the recycling section for reuse. After pressing, wash with deionized water at 70-75 ℃, then wash the discharge with deionized water at room temperature, and put it into the press until no liquid flows out before discharging. The filtrate is reused in the alkali refining section.

4. Post processing:
The refined folic acid wet product is dried in a boiling dryer at T ≤ 120 ℃ to obtain dried finished folic acid, which is then crushed and packaged in barrels.

In addition, the production process of folic acid also includes quality control and monitoring to ensure that the product quality meets standards. The entire production process generates a large amount of wastewater, which requires environmental protection treatment to reduce environmental pollution.