Folic Acid Powder

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In global dietary supplementation and mandatory food fortification programs, Folic Acid (Vitamin B9 / Pteroylglutamic Acid) is a non-negotiable critical nutrient. However, securing a stable, high-purity API that resists degradation during extended shelf-life is a primary challenge for formulators. Xi'an Tihealth provides an elite-tier, synthetically derived Folic Acid Powder engineered for maximum stability.

Manufactured under strict GMP protocols through an advanced multi-step condensation and crystallization process, our Folic Acid guarantees an assay purity of 97.0% to 102.0%, fully compliant with USP, EP, and BP pharmacopoeia standards. Presenting as a yellow to orange-yellow microcrystalline powder, it offers exceptional formulation versatility for prenatal multivitamins, B-complex capsules, and large-scale flour/cereal fortification, delivering highly bioavailable methyl-donor precursors required for cellular DNA synthesis.

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For R&D scientists, Folic Acid presents specific physical constraints, particularly regarding solubility, light sensitivity, and micro-dosing homogeneity. Our active pharmaceutical ingredient (API) is optimized for these industrial environments:

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• Micro-Dosing Homogeneity:
• Folic acid is dosed in micrograms (e.g., 400mcg - 800mcg per serving). Our highly controlled particle size distribution ensures seamless geometric dilution during dry blending, preventing "hot spots" (over-dosing) in your final tablet or capsule matrices.
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• Solubility Engineering:
• Folic acid is practically insoluble in cold water and sensitive to acidic pH. However, it dissolves readily in dilute alkaline solutions. We provide precise technical guidance for formulators looking to create stable liquid suspensions or injectables by utilizing specific sodium-salt conversions.
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• Exceptional Photostability:
• Vitamin B9 degrades rapidly when exposed to UV light. Our crystallization and downstream purification processes yield a highly stable lattice structure, which, when paired with our light-blocking bulk packaging, ensures zero degradation during global transit and storage.

Batch-to-batch consistency and strict control over residual solvents are vital for pharmaceutical compliance. Below is the analytical data sheet for our standard Folic Acid API.

Replacing non-compliant medical claims with scientifically validated mechanisms of action, this essential vitamin supports premium formulas targeting:

• Dietary Supplements (Capsules & Tablets):
• The essential API for prenatal vitamins, comprehensive B-complex formulations, and cognitive support supplements. Often blended with maltodextrin for precision micro-dosing.
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• Mandatory Food Fortification:
• Deployed globally in industrial flour milling, rice polishing, and commercial bakery operations to meet government-mandated folate fortification standards.
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• Infant & Maternity Nutrition:
• Strictly formulated into infant milk formulas and maternal nutritional powders to ensure developmental milestones are met safely.
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• Sports & Energy Nutrition:
• Added to energy drinks and recovery powders to support efficient amino acid metabolism and ATP synthesis.

Our Folic Acid is synthesized under strict pharmaceutical guidelines, ensuring maximum purity and the complete elimination of hazardous byproducts:

1.  
2. Condensation Reaction:
3. The process begins with the highly controlled tri-component condensation of 2,4,5-triamino-6-hydroxypyrimidine, p-aminobenzoyl-L-glutamic acid, and an appropriate three-carbon reactant (such as trichloroacetone or related compounds) in a buffered aqueous environment.
4.  
5. pH Adjustment & Crude Precipitation:
6. The reaction matrix is carefully adjusted to an acidic pH (approx. 2.5 - 3.0) to precipitate the crude folic acid compound, separating it from the reaction mother liquor.
7.  
8. Alkaline Refining & Decolorization:
9. The crude matrix is dissolved in a mild sodium hydroxide (alkaline) solution. Activated carbon is introduced to absorb impurities and correct the color profile.
10.  
11. Acidic Re-Precipitation & Washing:
12. Hydrochloric or sulfuric acid is reintroduced to precipitate the highly purified Folic Acid. It is then repeatedly washed with deionized water to remove residual salts and solvents.
13.  
14. Vacuum Drying & Micronization:
15. The purified wet cake is dried in a specialized fluid-bed dryer (kept under 120°C to prevent thermal degradation) and micronized to achieve the final USP-grade microcrystalline powder.

Folic acid is highly sensitive to UV light. Operating under an ISO9001:2015 & GMP Quality Management System, Xi'an Tihealth utilizes light-blocking, high-barrier packaging to ensure zero degradation during transit.

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How do I dissolve Folic Acid for liquid formulations?

Pure folic acid is practically insoluble in neutral water and ethanol. To formulate liquid drops or beverages, R&D teams must utilize dilute alkaline solutions (like sodium hydroxide or sodium carbonate) to convert the powder into a soluble sodium folate salt. We recommend tightly controlling the final pH to prevent re-precipitation.

Do you offer triturated (diluted) folic acid blends for easier manufacturing?

Yes. Because the required daily dose of folic acid is extremely small (400 mcg), achieving blend uniformity with 99% pure API can be difficult for some facilities. Upon request, we can provide precision-triturated blends (e.g., 1% or 10% folic acid) on carriers like maltodextrin or dicalcium phosphate to streamline your production.

Is this synthetically derived or extracted from food?

Our Folic Acid (Pteroylglutamic Acid) is synthetically derived. In the pharmaceutical and fortification industries, synthetic folic acid is universally preferred over food-derived folates because it is significantly more stable under heat/light and possesses a much higher bioavailability rate for human absorption.

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