Allopurinol Powder Cas No.315-30-0
Product Source: Synthetic
Product Specification: ≥98%
CAS No.: 315-30-0
Molecular Formula: C₅H₄N₄O
Molecular Weight: 136.11 g/mol
Testing Method: HPLC
Active Ingredient: Allopurinol
Product Characteristics: White or off-white crystalline powder.
Product Packaging: 1kg/bag; 25kg/drum
Storage Conditions: Protect from light; store in tightly closed containers
Shelf Life: 24 months
Declaration of Use: This product is intended for industrial use or scientific research only.
What is Allopurinol API?
High-Purity Allopurinol API | CAS 315-30-0
Allopurinol (CAS No. 315-30-0) is a structural analogue of hypoxanthine and a potent, orally active pharmaceutical ingredient used in the management of hyperuricemia and chronic gout. Manufactured under strict cGMP-compliant protocols at Xi'an Tihealth, our Allopurinol crystalline powder achieves an HPLC-validated purity of ≥98.0%. By functioning as a selective xanthine oxidase inhibitor, it effectively reduces the biosynthesis of uric acid. This pharmaceutical-grade API is optimized for the production of oral solid dosage forms, ensuring high batch-to-batch consistency and meeting the rigorous quality standards of global pharmacopoeias for the treatment of urate-related metabolic disorders.
Technical Specifications & TDS
| Parameter | Product Specification |
|---|---|
| Chemical Name | 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one |
| CAS Number | 315-30-0 |
| Molecular Formula | $C_{5}H_{4}N_{4}O$ |
| Molecular Weight | 136.11 g/mol |
| Assay (HPLC) | ≥ 98.0% |
| Appearance | White or off-white crystalline powder |
| Storage Conditions | Protect from light; store in tightly closed containers |
What is the mechanism of action?
Allopurinol facilitates a significant reduction in serum and urinary uric acid levels through a targeted enzymatic inhibition pathway:
- Competitive Enzyme Inhibition: Allopurinol acts as a substrate for and a competitive inhibitor of xanthine oxidase, the primary enzyme responsible for the sequential conversion of hypoxanthine to xanthine and xanthine to uric acid.
- Active Metabolite Synergy: Its primary metabolite, oxypurinol, is also a potent xanthine oxidase inhibitor with a significantly longer half-life, contributing to sustained therapeutic efficacy in preventing urate crystal deposition.
- Purine Catabolism Regulation: By blocking the terminal steps of purine catabolism without interfering with vital purine salvage pathways, it effectively manages systemic urate concentrations in hyperuricemic patients.
What are the primary industrial applications?
- Oral Solid Dosages: The foundational active ingredient for formulating immediate-release tablets prescribed for chronic gout management.
- Nephrology Therapeutics: Utilized in the development of pharmaceutical interventions for preventing calcium oxalate calculi and secondary hyperuricemia.
- Oncology Support: Critical API for drugs preventing Tumor Lysis Syndrome (TLS) in patients undergoing intensive chemotherapy for hematological malignancies.
Compliance & Safety Notice: This product is intended strictly for industrial formulation or scientific research purposes. Not for direct human consumption or individual use. Store in a cool, dry place protected from direct light to prevent crystalline degradation.
Frequently Asked Questions (FAQ)
Our Allopurinol API is manufactured under cGMP compliance and strictly follows current USP/EP/ChP pharmacopoeia standards. We provide full technical dossiers, including COA, MSDS, and HPLC validation data to support your regulatory filings.
Is this API suitable for combination therapy formulations?Yes. Our Allopurinol powder features excellent crystalline stability and consistent particle size distribution, making it ideal for integration into complex formulations, such as those combining xanthine oxidase inhibitors with uricosuric agents.
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