Huperzine A API CAS 102518-79-6
Product source: Natural plant extract
Content specification: ≥99%
CAS number: 102518-79-6
Testing method: HPLC
Active ingredient: Huperzine A
Product packaging: 1kg/bag; 25kg/drum
Product storage: Sealed, cool, dry and dark place
Shelf life: 24 months
Huperzine A API ≥99% | CAS 102518-79-6 | Selective Acetylcholinesterase Inhibitor
Huperzine A is a high-affinity sesquiterpene alkaloid derived from Huperzia serrata. It functions as a potent, reversible, and highly selective acetylcholinesterase (AChE) inhibitor. By crossing the blood-brain barrier (BBB), it prevents the enzymatic degradation of acetylcholine within the synaptic cleft, significantly enhancing cholinergic neurotransmission. At Xi'an Tihealth, we supply ultra-pure ≥ 99.0% API, validated for its exact enantiomeric profile. This pharmaceutical-grade crystalline powder is engineered for high-precision R&D and pharmaceutical manufacturing where exact microgram-level dosing and exceptional biological potency are the non-negotiable standards.
⚠️ HIGH-POTENCY SUBSTANCE HANDLING & RUO NOTICE
Research Use Only (RUO): This ≥ 99% Huperzine A is a pure active pharmaceutical ingredient (API) powder. It is supplied exclusively for professional laboratory research and industrial pharmaceutical manufacturing. It is NOT for direct human use.
Dosage Criticality: Huperzine A exhibits pharmacological activity at microgram (μg) levels. Handling the ≥99% pure powder requires high-precision micro-analytical balances and specialized personal protective equipment (PPE). Any unauthorized use or improper mixing leading to dosage toxicity is the sole responsibility of the user.
Pharmacological Mechanism and Neurotransmission Kinetics
Huperzine A enhances cognitive performance through targeted enzymatic modulation within the synaptic environment:
- Enzymatic "Locking": By reversibly binding to the active site of acetylcholinesterase, Huperzine A prevents the breakdown of acetylcholine (ACh). This increases the availability of ACh for binding to postsynaptic receptors, a key factor in memory encoding.
- NMDA Receptor Modulation: Research suggests that Huperzine A acts as a non-competitive antagonist of the NMDA receptor, protecting neurons against glutamate-induced excitotoxicity and oxidative stress.
- L-Isomer Integrity: Our ≥99% API ensures absolute dominance of the L-isomer, which provides 50–100 times the inhibitory potency compared to synthetic racemic mixtures.
Technical Data Sheet (TDS) & Quality Audit
| Assay (HPLC, Anhydrous) | ≥ 99.0% |
| CAS Number | 102518-79-6 |
| Specific Optical Rotation | -52.0° ~ -56.0° (Verified L-Isomer) |
| Heavy Metals | ≤ 10 ppm (As/Pb/Cd compliant) |
| Microbial Limits | ≤ 100 cfu/g (Strict control) |
Formulator's Audit: When dosing at the μg level, homogeneity is the primary safety risk. Xi'an Tihealth provides technical support for geometric dilution protocols to ensure a Coefficient of Variation (CV) ≤ 5% in your final formulation.
Global Research Procurement FAQ
The acetylcholinesterase inhibitory activity of Huperzine A is highly stereospecific. The natural L-isomer is significantly more potent than the D-isomer. Our ≥ 99% API is audited via polarimetry to ensure that no inactive isomers compromise the therapeutic integrity of your R&D data.
How do you prevent airborne contamination during the handling of ≥99% pure API?
Huperzine A ≥99% is a fine crystalline powder. At Xi'an Tihealth, we provide vacuum-sealed, nitrogen-purged packaging. We recommend that clients handle the material only within negative-pressure weighing hoods (isolators) to protect operators from accidental inhalation and to prevent cross-contamination in the facility.
What documentation supports international factory audits for this API?
Xi'an Tihealth provides a comprehensive technical package, including Method of Analysis (MOA), HPLC/MS chromatograms, and Batch Manufacturing Records (BMR). We maintain full traceability and support regulatory compliance for neuro-pharmacological drug registration.
Xi'an Tihealth Compliance Statement: Ultra-high purity raw material API ≥99%. For industrial and laboratory use only. User assumes all risks for unauthorized clinical applications.
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