High Purity γ-Aminobutyric Acid (GABA) API Powder | CAS 56-12-2

High Purity γ-Aminobutyric Acid (GABA) API Powder | CAS 56-12-2

Products Description Xi'an Tihealth γ-Aminobutyric Acid (GABA) Xi'an Tihealth provides premium-grade γ-Aminobutyric Acid (GABA, CAS 56-12-2) , produced via advanced microbial fermentation (Lactobacillus) to ensure high bio-affinity and safety. As the primary inhibitory...
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Products Description

GABA API Powder
Xi'an Tihealth γ-Aminobutyric Acid (GABA)

Xi'an Tihealth provides premium-grade γ-Aminobutyric Acid (GABA, CAS 56-12-2), produced via advanced microbial fermentation (Lactobacillus) to ensure high bio-affinity and safety. As the primary inhibitory neurotransmitter in the mammalian central nervous system, GABA acts as the brain's critical "braking system," downregulating neuronal excitability.

Our bulk GABA powder features an exceptional assay purity of ≥ 99.0% (HPLC) with excellent aqueous solubility. It is the cornerstone ingredient for advanced nutraceuticals targeting sleep architecture improvement, anxiolytic (anti-anxiety) support, and autonomic nervous system regulation. Supplied with comprehensive ISO and GMP-compliant dossiers.

Mechanism of Action

1. Neuronal Inhibition: GABA binds to specific post-synaptic receptors (GABA-A and GABA-B), opening ion channels that hyperpolarize the cell membrane, effectively counteracting excitatory neurotransmitters like glutamate.

2. Gut-Brain Axis Modulation: Exogenous GABA interacts with the enteric nervous system (ENS). Evidence suggests it modulates the autonomic nervous system via the vagus nerve, initiating systemic relaxation and mitigating somatic stress responses without necessitating direct blood-brain barrier (BBB) penetration.

Formulation Applications

  • Sleep Support Nutraceuticals: Formulated in capsules and functional shots to decrease sleep latency and improve REM sleep quality.
  • Stress Management Formulations: Synergistic stacking with Magnesium and L-Theanine for acute anxiolytic effect and mood stabilization.
  • Functional Foods & Beverages: Highly soluble profile ideal for "relaxation" RTD (Ready-To-Drink) beverages and gummies.

Certificate of Analysis Summary

Test Parameter Acceptance Criteria
Assay (GABA Content) ≥ 99.0% (HPLC)
Loss on Drying ≤ 0.5%
Heavy Metals (Pb/As/Cd/Hg) ≤ 10.0 ppm Total
Microbiology (Total Plate Count) ≤ 1000 CFU/g

Technical FAQ

Q: Does oral GABA cross the Blood-Brain Barrier (BBB)?
While direct BBB penetration of exogenous GABA is limited, clinical efficacy is achieved via the Gut-Brain Axis. It binds to GABA receptors in the enteric nervous system, stimulating the vagus nerve to induce systemic central nervous system relaxation.
Q: What is the manufacturing source of your GABA?
Our GABA is produced using a highly controlled, natural bio-fermentation process utilizing safe lactic acid bacteria, ensuring it is non-synthetic, non-GMO, and suitable for clean-label dietary supplements.

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