Nonapeptide Powder
English name: Nonapeptide-1
CAS number: 158563-45-2
Solubility: Easily soluble in water
Specification: 98%
Appearance: White powder
Storage conditions: 2 ℃~8 ℃
Packaging specification: 1g/bag
Storage method: Store in a cool, dry, and ventilated place, avoiding direct sunlight
Packaging specifications: 1-5kg/aluminum foil bag, cardboard box, 25kg/cardboard drum
Shelf life: Two years
Nonapeptide-1 API Powder (Melanostatine)
Biomimetic Cosmetic Peptide | MC1 Receptor Antagonist | HPLC Purified
⚠️ REGULATORY COMPLIANCE & INDUSTRIAL R&D: This product is a high-purity synthetic peptide API intended strictly for cosmetic formulation, dermatological research, and industrial compounding. It is not a finished drug product. Xi'an Tihealth guarantees sequence accuracy and ultra-low impurity profiles via stringent HPLC and MS verification.
Product Characterization & Mechanism
Xi'an Tihealth supplies premium Nonapeptide-1, a biomimetic small-molecule peptide consisting of 9 precise amino acids. Engineered specifically for high-end skin-brightening and dermatological repair formulations, this active ingredient functions as a highly targeted Melanocortin-1 (MC1) receptor antagonist.
By competitively binding to the MC1 receptor, Nonapeptide-1 effectively blocks the signal transmission of α-MSH (Melanocyte-stimulating hormone). This prevents the activation of tyrosinase, fundamentally inhibiting melanin synthesis at the cellular source without the cytotoxic side effects associated with traditional bleaching agents.
Technical Specification (TDS Profile)
| Analytical Parameter | Tihealth Standard |
|---|---|
| Product Name | Nonapeptide-1 (Melanostatine-5) |
| Structural Characteristics | Small molecule biomimetic peptide (9 amino acid sequence) |
| Peptide Purity (HPLC) | ≥ 98.0% |
| Appearance | White to off-white lyophilized powder |
| Safety Profile | High safety, non-cytotoxic, optimized for cosmetic integration |
Dermatological Applications & Efficacy
- Targeted Melanogenesis Inhibition: Radically diminishes pigmentation, evens skin tone, and fades hyperpigmentation spots by disrupting tyrosinase activation pathways.
- Antioxidant & mTOR Pathway Regulation: Modulates UV-A-induced oxidative stress and provides profound photoprotective effects, repairing cellular damage at the structural level.
- Collagen Matrix Support: Stimulates intrinsic collagen synthesis, enhancing dermal elasticity, firmness, and overall moisture retention to delay the visible aging process.
- Advanced Delivery Integration: Ideal for intensive serums, brightening creams, and active mesotherapy (injection beauty research) formulations.
Advanced Peptide Synthesis Technology
Xi'an Tihealth guarantees commercial scalability and uncompromising purity through dual synthesis pathways, tailored to specific client formulation viscosities and purity demands:
Solid-Phase Peptide Synthesis (SPPS)
Automated SPPS utilizes protective group chemistry (DCC condensation) to precisely elongate the 9-amino acid chain on a resin matrix. Ideal for highly scalable, automated bulk commercial production.
Liquid-Phase Synthesis & HPLC Purification
For applications requiring absolute zero-tolerance for byproducts, our liquid-phase protocols coupled with preparative HPLC ensure pharmaceutical-grade purity levels by eliminating truncated sequences.
Technical Support & Procurement FAQ
Is Nonapeptide-1 suitable for sensitive skin formulations?
Yes. Unlike traditional brightening agents like Hydroquinone or high-concentration acids which cause chemical exfoliation and irritation, Nonapeptide-1 is a biomimetic peptide. It inhibits melanin biologically at the receptor level, making it exceptionally safe and non-irritating for sensitive skin matrices.
Do you provide batch-specific HPLC and MS data?
Absolutely. Every commercial batch is accompanied by a comprehensive Certificate of Analysis (COA), including High-Performance Liquid Chromatography (HPLC) purity charts and Mass Spectrometry (MS) data to verify exact molecular weight and sequence integrity.
Can Xi'an Tihealth support custom peptide synthesis configurations?
Yes. Our R&D infrastructure allows us to act as a strategic synthesis partner. We can adjust specific counter-ions (such as acetate) or purity levels to seamlessly match your specific cosmetic formulation viscosity and stability requirements.
Accelerate Your Cosmetic Formulation R&D
Contact our technical sales team for custom synthesis plans, bulk pricing, and full analytical dossiers.
📧 peter@xatihealth.com 📞 WhatsApp: +86 13991246876
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