Valerian Root Extract Powder
Technical Data Sheet (TDS) & Specification Portfolio
| Analytical Parameter | Target Specification Limit | Result (Typical Batch) | Validated Methodology |
|---|---|---|---|
| Taxonomic Botanical Source | Dried rhizomes and roots of Valeriana officinalis L. | Verified | HPTLC Identity Profiling |
| Active Assay (Valerenic Acid) | ≥ 0.3% / ≥ 0.8% (EP11.0 Grade) | 0.35% / 0.86% | HPLC / GC-FID |
| Valerian Triterpenic Acids | ≥ 0.8% / ≥ 1.2% (Optional Spec) | Conforms | GC + Enterprise Standard |
| Appearance & State | Brown to dark brown fine powder | Complies | Visual Assessment |
| Loss on Drying (Moisture) | ≤ 5.0% | 3.8% | Halogen Moisture (USP <731>) |
| Heavy Metals (Pb, As, Cd) | Pb ≤ 2.0 ppm, As ≤ 1.0 ppm | Complies | ICP-MS (USP <233>) |
| Microbiological Limits | Total Plate ≤ 10,000 CFU/g | < 500 CFU/g | USP <2021> / <2022> |
Manufacturing & Processing Excellence
Low-Temp Countercurrent Extraction
Valerenic acids and the essential volatile oils (valepotriates) are highly sensitive to thermal degradation. Xi'an Tihealth replaces traditional high-heat decoction with precision low-temperature countercurrent extraction, maximizing the yield and structural integrity of the neuro-active phytochemicals.
Macroporous Resin Chromatography
To achieve pharmacopeial purity levels (≥0.8% Valerenic Acid), our extract undergoes advanced macroporous resin column chromatography. This efficiently strips away inert starches and heavy botanical waxes, yielding a highly concentrated, bioavailable active matrix suitable for small-dosage capsule filling.
Strict Residual Solvent Control
As a primary ingredient in clinical sleep aids, chemical safety is paramount. Every commercial lot undergoes rigorous Gas Chromatography-Headspace (GC-HS) testing to ensure residual solvents are virtually non-detectable, strictly conforming to the safety thresholds of USP <467>.
Biochemical Mechanisms & Neuromodulation
GABA-A Receptor Allosteric Modulation (Sedation)
Scientific consensus identifies Valerenic Acid as a potent positive allosteric modulator of GABA-A receptors. By inhibiting the enzymatic breakdown of gamma-aminobutyric acid (GABA) in the synaptic cleft, it significantly enhances neuro-inhibitory signaling, promoting physiological sedation and reducing sleep latency.
Serotonin (5-HT) Receptor Interaction (Anxiolytic)
In addition to GABAergic pathways, the active sesquiterpenes in Valerian Root exhibit partial agonistic behavior towards 5-HT5A (Serotonin) receptors. This biochemical interaction actively attenuates systemic stress responses, delivering documented anti-anxiety (anxiolytic) support without the cognitive impairment associated with synthetic benzodiazepines.
Adenosine Receptor Agonism (Cardiovascular Support)
Certain volatile constituents within the extract demonstrate mild activation of adenosine A1 receptors. This physiological mechanism assists in regulating localized vasodilation and stabilizing heart rate rhythms, offering auxiliary support against stress-induced cardiovascular strain.
Industrial Application Scenarios
Premium Sleep Supplements
The core active ingredient for formulating clinical-grade sleep onset capsules, prolonged-release tablets, and non-habit-forming nighttime recovery formulas.
Clinical Anxiolytics & Stress Relief
Heavily specified in dietary complexes aimed at mitigating generalized anxiety, nervous tension, and mood disorders in high-stress demographics.
Functional Botanical Beverages
Ratio extract variants (e.g., 10:1 or 20:1) are widely deployed as functional additives in relaxation teas, calming elixirs, and nighttime wellness shots.
Cardiovascular Adjuvant Support
Integrated into specialized formulas targeting age-related nervous system health and stress-induced cardiovascular strain in geriatric demographics.
B2B Wholesale Service & Supply Chain Logistics
♦ Multi-Tier Specification Matrix
We offer a complete gradient to match your budget and application: High-content Valerenic Acid (0.8%) for premium medicinal claims, and cost-effective Ratio Extracts (10:1) for bulk flavor and functional food additives.
♦ Guaranteed European Compliance
Valerian is highly regulated in Western markets. Our EP11.0 standardized series ensures your final product will seamlessly pass rigorous European and North American market-access and border control audits.
♦ Global Logistics & Stability
Operating an ISO9001:2015 facility, we maintain ton-level bulk stocks. We support annual framework agreements with tiered volume discounts and secure, priority maritime or air-freight delivery.
Packaging, Logistics & Secure Payment
Formulator & Procurement FAQ
Q1: What is the main difference between the Valerenic Acid specs and Ratio Extract powders?
The Valerenic Acid series (0.3% / 0.8%) are High-Content Monomers. These have undergone advanced chromatographic purification to guarantee a standardized concentration of the neuro-active compounds required for clinical-grade sleep therapeutics. Conversely, Ratio Extracts (e.g., 10:1) represent bulk concentration of the whole root, offering a highly cost-effective solution for functional foods, teas, and natural flavor additives where exact API standardization is not the primary regulatory requirement.
Q2: Valerian root is notorious for its strong, pungent odor. Do you offer deodorized or low-odor options?
The characteristic "earthy" or pungent odor of Valerian is naturally derived from Isovaleric acid, an inherent component of its volatile oil profile. While this odor is a sign of botanical authenticity, we understand it can be a formulating challenge. Xi'an Tihealth offers specialized low-odor extraction variants through specific solvent-stripping techniques, and our technical team can provide guidance on appropriate micro-encapsulation or excipient masking for your final dosage forms.
Q3: How do you guarantee compliance with the European Pharmacopoeia (EP11.0)?
European export requires absolute analytical precision. We utilize advanced Gas Chromatography (GC-FID) and High-Performance Liquid Chromatography (HPLC) to match the exact monographs outlined in EP11.0. Every batch is supplied with a comprehensive Certificate of Analysis (COA) verifying not only the Valerenic Acid content, but also strict limits on heavy metals, microbial bioburden, and residual solvents, ensuring frictionless EU market access.
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