Atractylodes Macrocephala Extract Liquid

Atractylodes Macrocephala Extract Liquid is a standardized botanical extract derived from the rhizomes of Atractylodes macrocephala Koidz. via subcritical water extraction technology. Enriched with bioactive polysaccharides (≥10%) and atractylenolides (≥0.1%), this extract adheres to Chinese Pharmacopoeia and cGMP standards, serving as a key ingredient in dietary supplements, pharmaceutical formulations, and cosmetic actives.

Certificate of Analysis

1. Splenic Function Support & Dampness Metabolism Regulation

In traditional Chinese medicine, this extract aligns with the therapeutic principle of "strengthening the spleen and dispelling dampness." Modern mechanistic studies reveal its polysaccharide fraction (≥10%) modulates gut microbiota composition, promoting the proliferation of beneficial bacteria (e.g., Bifidobacterium and Lactobacillus) while inhibiting pathogenic strains. This gut-brain axis regulation enhances intestinal water absorption and dampness elimination, evidenced by reduced fecal water content in rat models (p<0.05). Concurrently, atractylenolides inhibit hepatic steatosis by upregulating AMPK signaling pathways, optimizing lipid metabolism and supporting splenic metabolic functions.

2. Immune Response Enhancement via Macrophage Activation

The extract's bioactive polysaccharides (MW 50-100 kDa) exhibit immunomodulatory effects by activating macrophages (RAW 264.7 cell line) through toll-like receptor 4 (TLR4)/MyD88 signaling. This leads to enhanced phagocytic activity (2.3-fold increase in phagocytic index) and upregulated secretion of pro-inflammatory cytokines (TNF-α, IL-6) in vitro. In vivo studies in BALB/c mice demonstrate a 40% reduction in bacterial load in peritoneal cavity infections, attributable to improved neutrophil chemotaxis and reactive oxygen species (ROS) production.

3. Antioxidant Activity with DPPH Radical Scavenging

The extract demonstrates potent antioxidant capacity, with a half-maximal inhibitory concentration (IC50) of ≤50 μg/mL for DPPH radical scavenging, comparable to vitamin C (IC50 ~20 μg/mL). Key contributors include phenolic acids (e.g., ferulic acid) and atractylenolides, which neutralize free radicals and reduce malondialdehyde (MDA) levels in H2O2-induced oxidative stress models. In cosmetic formulations, a 2% concentration reduces facial melanin content by 12% after 8 weeks of use (clinical trial with 50 subjects), attributing to its dual effects on ROS scavenging and tyrosinase inhibition.

4. Gastrointestinal Motility Improvement (Preclinical Evidence)

Pharmacodynamic studies in Sprague-Dawley rats show a 25% increase in gastrointestinal transit rate following oral administration of the extract (100 mg/kg), mediated by enhanced acetylcholine release and upregulated interstitial cells of Cajal (ICC) activity. Mechanistically, atractylenolide I activates voltage-gated calcium channels (VGCCs) in smooth muscle cells, promoting rhythmic contractions. These effects are comparable to metoclopramide but with fewer side effects, supporting its use in functional dyspepsia adjunct therapy.

Raw Material Collection → Low-Temperature Pulverization → Ultrasonic Extraction → Filtration & Chromatography Purification → Vacuum Concentration → Quality Testing → Sterile Packaging → Global Distribution

The OEM services provided by Xi'an Tihealth Biotechnology Co., Ltd. have significant advantages

Custom Formulation: Adjust extract viscosity, solubility, and active ratios

Dosage Form Conversion: Spray-dried powder (water solubility ≥95%)

Regulatory Support: Documentation for FDA NDI, EU CPNP, and TGA submissions

Confidentiality: Non-disclosure agreements (NDAs) for proprietary formulas

As a biotechnology company, Tihealth Biotechnology Company provides international cross-border e-commerce logistics services with the following characteristics:

1. International express delivery services

2. Dedicated logistics services

3. Support dual clearing service

Q1: What is the shelf life under refrigeration?
A: 36 months when stored at 2-8°C in unopened original packaging.

Q2: Can this extract be used in infant products?
A: Compliant with Codex Alimentarius when diluted below 2% concentration.

Q3: What is the lead time for OEM orders?
A: 14-21 days post-formula approval and deposit receipt.

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